{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:53:44Z","timestamp":1793332424732,"version":"4.5.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["31570949"],"award-info":[{"award-number":["31570949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-like transcript-1 (sTLT-1) is a new indicator. However, the relationship between these two markers and CAD, especially in acute coronary syndrome (ACS), has not been elucidated. This study aimed to investigate CD62P expression on the platelet surface and sTLT-1 expression in serum, as well as to assess their relationship with CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured the levels of CD62P and sTLT-1 in 83 patients with CAD compared to 49 controls. The association of these indicators with age, blood pressure, lipid profile, body mass index, and liver injury marker level were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD62P concentration was higher in CAD patients than in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), especially in acute myocardial infarction (AMI) patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Serum sTLT-1 concentration was higher in the AMI and unstable angina pectoris (UAP) groups than in the normal control (NC) group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The consistency of sTLT-1 and CD62P expression levels in CAD patients indicates that sTLT-1 level, the same as CD62P, may be a new marker of platelet activation that is positively related to CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-020-01663-2","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T06:03:45Z","timestamp":1598249025000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study"],"prefix":"10.1186","volume":"20","author":[{"given":"Li","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0184-2133","authenticated-orcid":false,"given":"Zhiqiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"issue":"1 Suppl","key":"1663_CR1","first-page":"I16","volume":"81","author":"P Grande","year":"1990","unstructured":"Grande P, Grauholt AM, Madsen JK. Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. Circulation. 1990;81(1 Suppl):I16\u20139 I22-3 https:\/\/pubmed.ncbi.nlm.nih.gov\/2136815\/.","journal-title":"Circulation"},{"issue":"8","key":"1663_CR2","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1084\/jem.191.8.1413","volume":"191","author":"PS Frenette","year":"2000","unstructured":"Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, Kehrel B, et al. P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. 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Mol Cell Biochem. 2016;419(1\u20132):125\u201333. https:\/\/doi.org\/10.1007\/s11010-016-2756-4https:\/\/pubmed.ncbi.nlm.nih.gov\/27406211\/.","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"1663_CR4","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/s0002-9149(96)00861-2","volume":"79","author":"AN Tenaglia","year":"1997","unstructured":"Tenaglia AN, Buda AJ, Wilkins RG, Barron MK, Jeffords PR, Vo K, et al. Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris. Am J Cardiol. 1997;79(6):742\u20137. https:\/\/doi.org\/10.1016\/s0002-9149(96)00861-2https:\/\/pubmed.ncbi.nlm.nih.gov\/9070552\/.","journal-title":"Am J Cardiol"},{"issue":"4","key":"1663_CR5","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2004-01-0315","volume":"104","author":"AV Washington","year":"2004","unstructured":"Washington AV, Schubert RL, Quigley L, Disipio T, Feltz R, Cho EH, et al. A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets. Blood. 2004;104(4):1042\u20137. https:\/\/doi.org\/10.1182\/blood-2004-01-0315https:\/\/pubmed.ncbi.nlm.nih.gov\/15100151\/.","journal-title":"Blood"},{"issue":"10","key":"1663_CR6","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1182\/blood-2002-02-0523","volume":"100","author":"AV Washington","year":"2002","unstructured":"Washington AV, Quigley L, McVicar DW. Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. Blood. 2002;100(10):3822\u20134. https:\/\/doi.org\/10.1182\/blood-2002-02-0523https:\/\/pubmed.ncbi.nlm.nih.gov\/12393607\/.","journal-title":"Blood"},{"issue":"11","key":"1663_CR7","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.4049\/jimmunol.1102674","volume":"188","author":"M Derive","year":"2012","unstructured":"Derive M, Bouazza Y, Sennoun N, Marchionni S, Quigley L, Washington V, et al. Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. J Immunol. 2012;188(11):5585\u201392. https:\/\/doi.org\/10.4049\/jimmunol.1102674https:\/\/pubmed.ncbi.nlm.nih.gov\/22551551\/.","journal-title":"J Immunol"},{"issue":"11","key":"1663_CR8","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.ehj.2004.01.023","volume":"25","author":"TW Koh","year":"2004","unstructured":"Koh TW, DeSouza AC, Pepper JR. 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Blood. 2018;132(23):2427\u20139. https:\/\/doi.org\/10.1182\/blood-2018-10-879676https:\/\/pubmed.ncbi.nlm.nih.gov\/30523125\/.","journal-title":"Blood"},{"issue":"1","key":"1663_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3892\/etm.2018.6137","volume":"16","author":"R Fu","year":"2018","unstructured":"Fu R, Song X, Su D, Li S, Gao L, Ji C. Serum STLT-1 and bilirubin levels in patients with acute coronary syndrome and correlation with prognosis. 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This study was approved by the Medical Ethics Committee of Xiangya Hospital of Central South University (approval NO: 201192). The study was performed in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"387"}}