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Clinically, the ejection fraction (EF) is the primary index of cardiac function. However, changes of EF usually occur later in the disease course. Feature tracking (FT) and deformable registration algorithm (DRA) have become appealing techniques for myocardial strain assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty patients with iLVNC (36.7\u2009\u00b1\u200913.3\u2009years old) and fifty healthy volunteers (42.3\u2009\u00b1\u200913.6\u2009years old) underwent cardiovascular magnetic resonance (CMR) examination on a 1.5\u2009T MR scanner. Strain values in the radial, circumferential, longitudinal directions were analyzed based on the short-axis and long-axis cine images using FT and DRA methods. The iLVNC patients were further divided based on the ejection fraction, into EF\u2009\u2265\u200950% group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) and EF\u2009&lt;\u200950% group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919). Receiver-operating-characteristic (ROC) analysis was performed to assess the diagnostic performance of the global strain values. Intraclass correlation coefficient (ICC) analysis was used to evaluate the intra- and inter-observer agreement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global radial strain (GRS) was statistically lower in EF\u2009\u2265\u200950% group compared with control group [GRS (DRA)\/% vs. controls: 34.6\u2009\u00b1\u20097.0 vs. 37.6\u2009\u00b1\u20097.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; GRS (FT)\/% vs. controls: 37.4\u2009\u00b1\u200913.2 vs. 56.9\u2009\u00b1\u200916.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01]. ROC analysis of global strain values derived from DRA and FT demonstrated high area under curve (range, 0.743\u20130.854). DRA showed excellent intra- and inter-observer agreement of global strain in both iLVNC patients (ICC: 0.995\u20130.999) and normal controls (ICC: 0.934\u20130.996). While for FT analysis, global radial strain of normal controls showed moderate intra-observer (ICC: 0.509) and poor inter-observer agreement (ICC: 0.394).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with iLVNC, DRA can be used to quantitatively analyze the strain of left ventricle, with global radial strain being an earlier marker of LV systolic dysfunction. DRA has better reproducibility in evaluating both the global and segmental strain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-020-01668-x","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T03:03:04Z","timestamp":1599102184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantification of myocardial strain in patients with isolated left ventricular non-compaction and healthy subjects using deformable registration algorithm: comparison with feature tracking"],"prefix":"10.1186","volume":"20","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wetzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-3711","authenticated-orcid":false,"given":"Heshui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"issue":"9995","key":"1668_CR1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0140-6736(14)61282-4","volume":"386","author":"JA Towbin","year":"2015","unstructured":"Towbin JA, Lorts A, Jefferies JL. 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