{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:57:29Z","timestamp":1740135449326,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Meigs\u2019 syndrome is a rare disease characterized by a triad of presentations, including benign ovarian tumor, ascites, and pleural effusion. However, a clinical diagnosis of Meigs\u2019 syndrome remains challenging because pleural and ascitic effusions can be common findings in a variety of underlying conditions. Furthermore, these findings can often be misdiagnosed as pleural and peritoneal dissemination caused by potentially malignant tumors, leading to the administration of improper treatment.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>We described a case of an 85-year-old postmenopausal female patient with atypical Meigs\u2019 syndrome presenting with right-sided pleural effusion, notable leg edema, and trivial ascites, which was initially mistaken as heart failure with preserved ejection fraction. However, pleural effusion was totally ineffective against diuretic therapy. Subsequently, thoracentesis yielded serosanguineous exudative effusion. Moreover, refractory pleural effusions and abdominal\/pelvic computed tomography and magnetic resonance imaging findings strongly suggested bilateral malignant ovarian tumors with pleural dissemination. Repetitive negative cytological results allowed the patient to undergo bilateral salpingo-oophorectomy. Finally, a definitive diagnosis of Meigs\u2019 syndrome was made by confirming the presence of a benign mitotically active cellular fibroma of the ovary by pathology and that pleural effusion resolved following tumor resection.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our case highlights the clinical importance of assessing Meigs\u2019 syndrome in the diagnostic workup of pleural effusion in postmenopausal female patients. Given the favorable prognosis of Meigs\u2019 syndrome, clinicians should consider surgical resection, even with potentially malignant ovarian tumors with accompanying pleural effusion, ascites, or both.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01718-4","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T18:03:01Z","timestamp":1602093781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Meigs\u2019 syndrome mimicking heart failure with preserved ejection fraction: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Yoko","family":"Murayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Kamoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-7653","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Isogai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"issue":"5","key":"1718_CR1","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/0002-9378(54)90258-6","volume":"67","author":"JV Meigs","year":"1954","unstructured":"Meigs JV. Fibroma of the ovary with ascites and hydrothorax; Meigs\u2019 Syndrome. Am J Obstet Gynecol. 1954;67(5):962\u201385.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"1718_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/j.2205-0140.2012.tb00140.x","volume":"15","author":"S Saha","year":"2012","unstructured":"Saha S, Robertson M. Meigs\u2019 and Pseudo-Meigs\u2019 syndrome. Australas J Ultrasound Med. 2012;15(1):29\u201331.","journal-title":"Australas J Ultrasound Med"},{"issue":"49","key":"1718_CR3","doi-asserted-by":"publisher","first-page":"e2114","DOI":"10.1097\/MD.0000000000002114","volume":"94","author":"R Krenke","year":"2015","unstructured":"Krenke R, Maskey-Warzechowska M, Korczynski P, Zielinska-Krawczyk M, Klimiuk J, Chazan R, Light RW. Pleural Effusion in Meigs\u2019 Syndrome-Transudate or Exudate?: systematic review of the literature. Medicine (Baltimore). 2015;94(49):e2114.","journal-title":"Medicine (Baltimore)"},{"issue":"10223","key":"1718_CR4","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1016\/S0140-6736(20)30111-2","volume":"395","author":"Y Taniguchi","year":"2020","unstructured":"Taniguchi Y, Nishikawa H, Maeda N, Terada Y. Breathlessness, Pleural Effusions, Fibromas, and Meigs Syndrome: Look Beyond the Chest and Don\u2019t Delay! Lancet. 2020;395(10223):e32.","journal-title":"Lancet"},{"issue":"21","key":"1718_CR5","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","volume":"64","author":"RJ Mentz","year":"2014","unstructured":"Mentz RJ, Kelly JP, von Lueder TG, Voors AA, Lam CS, Cowie MR, Kjeldsen K, Jankowska EA, Atar D, Butler J, et al. Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. 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We also obtained informed consent from the patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors confirm that written consent for submission and publication of this case report, including the images and associated video, has been obtained from the patient. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"436"}}