{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:52:23Z","timestamp":1775267543013,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sub-program of the key project of Digestive Collaborative Development Center of Gastroenterology, Beijing Hospital Administration Center","award":["xxz0607"],"award-info":[{"award-number":["xxz0607"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To investigate the long-term outcome of patients with acute ST-segment elevation myocardial infarction (STEMI) and a chronic total occlusion (CTO) in a non-infarct-related artery (IRA) and the risk factors for mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The enrolled cohort comprised 323 patients with STEMI and multivessel diseases (MVD) that received a primary percutaneous coronary intervention between January 2008 and November 2013. The patients were divided into two groups: the CTO group (n\u2009=\u200997) and the non-CTO group (n\u2009=\u2009236). The long-term major adverse cardiovascular and cerebrovascular events (MACCE) experienced by each group were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The rates of all-cause mortality and MACCE were significantly higher in the CTO group than they were in the non-CTO group. Cox regression analysis showed that an age\u2009\u2265\u200965\u00a0years (OR\u2009=\u20093.94, 95% CI: 1.47\u201310.56, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), a CTO in a non-IRA(OR\u2009=\u20095.09, 95% CI: 1.79\u2009~\u200914.54, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), an in-hospital Killip class\u2009\u2265\u20093 (OR\u2009=\u20094.32, 95% CI: 1.71\u2009~\u200910.95, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and the presence of renal insufficiency (OR\u2009=\u20095.32, 95% CI: 1.49\u2009~\u200919.01, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), stress ulcer with gastraintestinal bleeding (SUB) (OR\u2009=\u20096.36, 95% CI: (1.45\u2009~\u200928.01, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) were significantly related the 10-year mortality of patients with STEMI and MVD; an in-hospital Killip class\u2009\u2265\u20093 (OR\u2009=\u20092.97,95% CI:1.46\u2009~\u20096.03, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and the presence of renal insufficiency (OR\u2009=\u20095.61, 95% CI: 1.19\u2009~\u200926.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) were significantly related to the 10-year mortality of patients with STEMI and a CTO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The presence of a CTO in a non-IRA, an age\u2009\u2265\u200965\u00a0years, an in-hospital Killip class\u2009\u2265\u20093, and the presence of renal insufficiency, and SUB were independent risk predictors for the long-term mortality of patients with STEMI and MVD; an in-hospital Killip class\u2009\u2265\u20093 and renal insufficiency were independent risk predictors for the long-term mortality of patients with STEMI and a CTO.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-021-01874-1","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T12:02:46Z","timestamp":1612008166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The long-term impact of a chronic total occlusion in a non-infarct-related artery on acute ST-segment elevation myocardial infarction after primary coronary intervention"],"prefix":"10.1186","volume":"21","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-3385","authenticated-orcid":false,"given":"Le-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui-Bao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu-Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Shi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiu-Chang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu-Hua","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Sheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"key":"1874_CR1","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1001\/jama.293.12.1501","volume":"293","author":"JD Flaherty","year":"2005","unstructured":"Flaherty JD, Davidson CJ. 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This study was conducted with approval from the Ethics Committee of Beijing Chaoyang Hospital. This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patient guardians signed a document of informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}