{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:18Z","timestamp":1787162778335,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14DZ2260200"],"award-info":[{"award-number":["14DZ2260200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Clinical Medical Center for Kidney Disease Project support by Shanghai Municipal Health Commission","award":["2017ZZ01015"],"award-info":[{"award-number":["2017ZZ01015"]}]},{"name":"Shanghai Municipal Hospital Frontier Technology Project supported by Shanghai ShenKang Hospital Development Center","award":["SHDC12018127"],"award-info":[{"award-number":["SHDC12018127"]}]},{"name":"Xiamen Science and Technology Plan in 2018","award":["3502Z20184009"],"award-info":[{"award-number":["3502Z20184009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fluid overload is related to the development and prognosis of cardiac surgery-associated acute kidney injury (CSA-AKI). The study is to investigate the influence of serum creatinine (SCr) corrected by fluid balance on the prognosis of patients with cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study was conducted in 1334 patients who underwent elective cardiac surgery from January 1 to December 31, 2015. Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI were applied to identify CSA-AKI. SCr was measured every 24\u00a0h during ICU period and was accordingly adjusted for cumulative fluid balance. Changes in SCr, defined as \u2206Crea, were determined by difference between before and after adjustment for cumulative fluid balance. All patients were then divided into three groups: underestimation group (\u2206Crea\u2009\u2265\u2009P\n                      <jats:sub>75<\/jats:sub>\n                      ), normal group (P\n                      <jats:sub>25<\/jats:sub>\n                      \u2009&lt;\u2009\u2206Crea\u2009&lt;\u2009P\n                      <jats:sub>75<\/jats:sub>\n                      ) and overestimation group (\u2206Crea\u2009\u2264\u2009P\n                      <jats:sub>25<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of AKI increased from 29.5% to 31.8% after adjustment for fluid balance. Patients in underestimation group showed prolonged length of ICU stay compared with normal group and overestimation group (3.2 [1.0\u20134.0] vs 2.1 [1.0\u20133.0] d,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; 3.2\u00a0 [1.0\u20134.0] vs 2.3 [1.0\u20133.0] d,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Length of hospital stay and mechanical ventilation dependent days in underestimation group were significantly longer than normal group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis showed age, baseline SCr and left ventricular ejection fraction were independently associated with underestimation of creatinine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cumulative fluid balance after cardiac surgery disturbs accurate measurement of serum creatinine. Patients with underestimation of SCr were associated with poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-021-01879-w","type":"journal-article","created":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T11:02:52Z","timestamp":1612090972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hemodilution is associated with underestimation of serum creatinine in cardiac surgery patients: a retrospective analysis"],"prefix":"10.1186","volume":"21","author":[{"given":"Jifu","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-2729","authenticated-orcid":false,"given":"Xiaoqiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"key":"1879_CR1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0002-9343(98)00058-8","volume":"104","author":"GM Chertow","year":"1998","unstructured":"Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J. 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The need for informed consents were waived by the Institutional Ethics Committee because this was a retrospective analysis of data collected prospectively with no breach of privacy or anonymity.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"61"}}