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Homocysteine, blood glucose and lipid profile in whole blood\/serum were measured using standard laboratory methods. Hypertension was diagnosed if average of 5 consecutive blood pressure (BP) measurements obtained using a mercury sphygmomanometer was equal to or higher than 140 systolic and\/or 90\u00a0mmHg diastolic or the individual is on antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as Hcy\u2009&gt;\u200910\u00a0\u00b5mol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 156 participants, 72 (43.5%) were hypertensive, of whom 18 had HHcy. Subjects with HHcy were significantly (p\u2009&lt;\u20090.05) older (41.5 vs. 40.6yrs), had lower HDL-cholesterol (0.6 vs. 0.8\u00a0mmol\/L) and higher systolic (145.5 vs. 126.0\u00a0mmHg) and diastolic BP (92.9 vs. 79.6\u00a0mmHg), compared to those without HHcy. Intake of alcohol and a 1\u00a0yr increase in age were respectively and significantly (p\u2009&lt;\u20090.05) associated with a 1.54 and 0.10\u00a0\u00b5mol\/L increase in Hcy. In a multivariable model adjusted for age, sex and body mass index, a 1\u00a0\u00b5mol\/L increase in Hcy, was associated with a 1.69\u00a0mmHg and 1.34\u00a0mmHg increase in systolic and diastolic pressure (p\u2009&lt;\u20090.0001) respectively; and a 0.01\u00a0mmol\/L decrease in HDL-cholesterol (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HHcy occurs among hypertensive Nigerians and it is independently associated with age, HDL-cholesterol, systolic and diastolic BP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-021-01913-x","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T18:02:51Z","timestamp":1613671371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hyperhomocysteinemia and its relations to conventional risk factors for cardiovascular diseases in adult Nigerians: the REMAH study"],"prefix":"10.1186","volume":"21","author":[{"given":"Babangida S.","family":"Chori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Danladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassey A.","family":"Inyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Okoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell M.","family":"Nwegbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adewale L.","family":"Alli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine N.","family":"Odili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"1913_CR1","unstructured":"Murray CJ, Aravkin AY, Zheng P, et al. 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