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MicroRNAs (miRNAs) are involved in the formation of atherosclerosis. However, the alteration of miRNA profile in EAT during atherosclerosis is still uncovered.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The miRNA expression profiles of EAT from non-coronary atherosclerosis disease (CON, n\u2009=\u20093) and coronary atherosclerosis disease (CAD, n\u2009=\u20095) patients was performed to detect the differentially expressed miRNA. Then the expression levels of miRNA in other CON (n\u2009=\u20095) and CAD (n\u2009=\u200916) samples were confirmed by realtime-PCR. miR-200b-3p mimic was used to overexpress the miRNA in HUVECs. The apoptosis of HUVECs cells was induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and ox-LDL, and detected by Annexin V\/PI Staining, Caspase 3\/7 activity and the expression of BCL-2 and BAX.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>250 miRNAs were differentially expressed in EAT from CAD patients, which were associated with metabolism, extracellular matrix and inflammation process. Among the top 20 up-regulated miRNAs, the expression levels of miR-200 family members (hsa-miR-200b\/c-3p, miR-141-3p and miR-429), which were rich in endothelial cells, were increased in EAT from CAD patients significantly. Upregulation of miR-200 family members was dependent on the oxidative stress. The overexpression of miR-200b-3p could promote endothelial cells apoptosis under oxidative stress by targeting HDAC4 inhibition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study suggests that EAT derived miR-200b-3p promoted oxidative stress induced endothelial cells damage by targeting HDAC4, which may provide a new and promising therapeutic target for AS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-021-01980-0","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T16:03:34Z","timestamp":1618243414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis"],"prefix":"10.1186","volume":"21","author":[{"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naixuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"issue":"25","key":"1980_CR1","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1161\/CIRCULATIONAHA.105.537878","volume":"111","author":"P Libby","year":"2005","unstructured":"Libby P, Theroux P. 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All patients enrolled in this study signed the informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"172"}}