{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:13:03Z","timestamp":1772165583256,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myocardial infarction (AMI) is myocardial necrosis caused by acute coronary ischemia and hypoxia. It can be complicated by arrhythmia, shock, heart failure and other symptoms that can be life-threatening. A multi-regulator driven dysfunction module for AMI was constructed. It is intended to explore the pathogenesis and functional pathways regulation of acute myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Combining differential expression analysis, co-expression analysis, and the functional enrichment analysis, a set of expression disorder modules related to AMI was obtained. Hypergeometric test was performed to calculate the potential regulatory effects of multiple factors on the module, identifying a range of non-coding RNA and transcription factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4551 differentially expressed genes for AMI and seven co-expression modules were obtained. These modules are primarily involved in the metabolic processes of prostaglandin transport processes, regulating DNA recombination and AMPK signal transduction. Based on this set of functional modules, 3 of 24 transcription factors (TFs) including NFKB1, MECP2 and SIRT1, and 3 of 782 non-coding RNA including miR-519D-3P, TUG1 and miR-93-5p were obtained. These core regulators are thought to be involved in the progression of AMI disease. Through the AMPK signal transduction, the critical gene stearoyl-CoA desaturase (SCD) can lead to the occurrence and development of AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, a dysfunction module was used to explore the pathogenesis of multifactorial mediated AMI and provided new methods and ideas for subsequent research. It helps researchers to have a deeper understanding of its potential pathogenesis. The conclusion provides a theoretical basis for biologists to design further experiments related to AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-021-02011-8","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T08:21:36Z","timestamp":1618906896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SCD leads to the development and progression of acute myocardial infarction through the AMPK signaling pathway"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-3128","authenticated-orcid":false,"given":"Lijie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"2011_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/CRD.0000000000000190","volume":"26","author":"D Acharya","year":"2018","unstructured":"Acharya D. Predictors of outcomes in myocardial infarction and cardiogenic shock. Cardiol Rev. 2018;26:255\u201366.","journal-title":"Cardiol Rev"},{"key":"2011_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11886-014-0557-5","volume":"17","author":"G Arora","year":"2015","unstructured":"Arora G, Bittner V. Chest pain characteristics and gender in the early diagnosis of acute myocardial infarction. Curr Cardiol Rep. 2015;17:5.","journal-title":"Curr Cardiol Rep"},{"key":"2011_CR3","first-page":"1172","volume":"40","author":"D Sinclair","year":"1994","unstructured":"Sinclair D. Myocardial infarction. Considerations for geriatric patients. Can Fam Phys. 1994;40:1172\u20137.","journal-title":"Can Fam Phys"},{"key":"2011_CR4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cpcardiol.2006.08.004","volume":"31","author":"EH Yang","year":"2006","unstructured":"Yang EH, Brilakis ES, Reeder GS, Gersh BJ. Modern management of acute myocardial infarction. Curr Probl Cardiol. 2006;31:769\u2013817.","journal-title":"Curr Probl Cardiol"},{"key":"2011_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/MCA.0000000000000040","volume":"25","author":"ZB Liu","year":"2014","unstructured":"Liu ZB, Fu XH, Wei G, Gao JL. Cytochrome c release in acute myocardial infarction predicts poor prognosis and myocardial reperfusion on contrast-enhanced magnetic resonance imaging. Coron Artery Dis. 2014;25:66\u201372.","journal-title":"Coron Artery Dis"},{"issue":"Suppl","key":"2011_CR6","first-page":"43","volume":"59","author":"AS Mullasari","year":"2011","unstructured":"Mullasari AS, Balaji P, Khando T. Managing complications in acute myocardial infarction. J Assoc Phys India. 2011;59(Suppl):43\u20138.","journal-title":"J Assoc Phys India"},{"key":"2011_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00129804-200107000-00011","volume":"24","author":"NM Scroggins","year":"2001","unstructured":"Scroggins NM. Recognition and management of inferior wall myocardial infarctions and right ventricular infarcts. J Infus Nurs. 2001;24:263\u20137.","journal-title":"J Infus Nurs"},{"key":"2011_CR8","first-page":"815","volume":"191","author":"JP Bounhoure","year":"2007","unstructured":"Bounhoure JP, Ouldzen H, Carrie D, Alibelli MJ, Puel J. Myocardial infarction with angiographically normal coronary arteries myth or reality? Bull Acad Natl Med. 2007;191:815\u201324 (discussion 24\u201325).","journal-title":"Bull Acad Natl Med"},{"key":"2011_CR9","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/ncpcardio1373","volume":"5","author":"I Klem","year":"2008","unstructured":"Klem I, Kim RJ. Assessment of microvascular injury after acute myocardial infarction: the importance of the area at risk. Nat Clin Pract Cardiovasc Med. 2008;5:756\u20137.","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2011_CR10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3909\/ricm0692","volume":"15","author":"S Hebsur","year":"2014","unstructured":"Hebsur S, Vakil E, Oetgen WJ, Kumar PN, Lazarous DF. Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in the prevention of myocardial infarction. Rev Cardiovasc Med. 2014;15:168\u201375.","journal-title":"Rev Cardiovasc Med"},{"key":"2011_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.amjmed.2013.09.031","volume":"127","author":"JS Alpert","year":"2014","unstructured":"Alpert JS, Thygesen KA, White HD, Jaffe AS. Diagnostic and therapeutic implications of type 2 myocardial infarction: review and commentary. Am J Med. 2014;127:105\u20138.","journal-title":"Am J Med"},{"key":"2011_CR12","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/0735-1097(92)90033-J","volume":"20","author":"RM Jacoby","year":"1992","unstructured":"Jacoby RM, Nesto RW. Acute myocardial infarction in the diabetic patient: pathophysiology, clinical course, and prognosis. J Am Coll Cardiol. 1992;20:736\u201344.","journal-title":"J Am Coll Cardiol"},{"key":"2011_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1177\/0885066617696851","volume":"32","author":"SI Lee","year":"2017","unstructured":"Lee SI, Lee SY, Choi CH, Park KY, Park CH. Left heart decompression in acute complicated myocardial infarction during extracorporeal membrane oxygenation. J Intensive Care Med. 2017;32:405\u20138.","journal-title":"J Intensive Care Med"},{"key":"2011_CR14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/MCA.0000000000000259","volume":"26","author":"T Graf","year":"2015","unstructured":"Graf T, Desch S, Eitel I, Thiele H. Acute myocardial infarction and cardiogenic shock: pharmacologic and mechanical hemodynamic support pathways. Coron Artery Dis. 2015;26:535\u201344.","journal-title":"Coron Artery Dis"},{"key":"2011_CR15","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.mcna.2007.03.006","volume":"91","author":"ED Aymong","year":"2007","unstructured":"Aymong ED, Ramanathan K, Buller CE. Pathophysiology of cardiogenic shock complicating acute myocardial infarction. Med Clin N Am. 2007;91:701\u201312.","journal-title":"Med Clin N Am"},{"key":"2011_CR16","first-page":"203","volume":"2","author":"M Norton","year":"1993","unstructured":"Norton M, Letizia M, Jennrich JA. Right ventricular infarction vs. left ventricular infarction: a review of pathophysiology, medical treatment, and nursing care. Medsurg Nurs. 1993;2:203\u20139.","journal-title":"Medsurg Nurs"},{"issue":"631\u201349","key":"2011_CR17","first-page":"vi","volume":"27","author":"TJ Pollard","year":"2000","unstructured":"Pollard TJ. The acute myocardial infarction. Prim Care. 2000;27(631\u201349):vi.","journal-title":"Prim Care"},{"key":"2011_CR18","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.ahj.2010.10.008","volume":"160","author":"L Bolognese","year":"2010","unstructured":"Bolognese L. Changing patterns of ST-elevation myocardial infarction epidemiology. Am Heart J. 2010;160:S1\u20133.","journal-title":"Am Heart J"},{"issue":"879\u2013887","key":"2011_CR19","first-page":"e1","volume":"128","author":"T Gupta","year":"2015","unstructured":"Gupta T, Harikrishnan P, Kolte D, Khera S, Aronow WS, Mujib M, Palaniswamy C, Sule S, Jain D, Ahmed A, Lanier GM, Cooper HA, Frishman WH, Fonarow GC, Panza JA. Outcomes of acute myocardial infarction in patients with hypertrophic cardiomyopathy. Am J Med. 2015;128(879\u2013887):e1.","journal-title":"Am J Med"},{"key":"2011_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1556\/650.2016.30349","volume":"157","author":"J Tomcsanyi","year":"2016","unstructured":"Tomcsanyi J, Tako K, Sharman B. Recurrent acute myocardial infarction as a thromboembolic complication of atrial fibrillation. Orv Hetil. 2016;157:191\u20133.","journal-title":"Orv Hetil"},{"key":"2011_CR21","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1136\/bmj.309.6962.1129","volume":"309","author":"AD Flapan","year":"1994","unstructured":"Flapan AD. Management of patients after their first myocardial infarction. BMJ. 1994;309:1129\u201334.","journal-title":"BMJ"},{"key":"2011_CR22","first-page":"21","volume":"62","author":"P Jariwala","year":"2010","unstructured":"Jariwala P, Chandra S. Diagnosis and management of failed thrombolytic therapy for acute myocardial infarction. Indian Heart J. 2010;62:21\u20138.","journal-title":"Indian Heart J"},{"issue":"Suppl 6","key":"2011_CR23","first-page":"83S","volume":"5","author":"F Bovenzi","year":"2004","unstructured":"Bovenzi F, De Luca L, de Luca I. Which is the best reperfusion strategy for patients with high-risk myocardial infarction? Ital Heart J. 2004;5(Suppl 6):83S-91S.","journal-title":"Ital Heart J"},{"key":"2011_CR24","first-page":"258","volume":"64","author":"E Mintz","year":"1997","unstructured":"Mintz E. Emergency department management of acute myocardial infarction. Mt Sinai J Med. 1997;64:258\u201374.","journal-title":"Mt Sinai J Med"},{"key":"2011_CR25","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res. 2013;41:D991\u20135.","journal-title":"Nucleic Acids Res"},{"key":"2011_CR26","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.","journal-title":"Nucleic Acids Res"},{"key":"2011_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinf. 2008;9:559.","journal-title":"BMC Bioinf"},{"key":"2011_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. Cluster profiler: an R package for comparing biological themes among gene clusters. Omics J integr Biol. 2012;16:284\u20137.","journal-title":"Omics J integr Biol"},{"key":"2011_CR29","doi-asserted-by":"publisher","first-page":"e1005598","DOI":"10.1371\/journal.pcbi.1005598","volume":"13","author":"DE Carlin","year":"2017","unstructured":"Carlin DE, Demchak B, Pratt D, Sage E, Ideker T. Network propagation in the cytoscape cyberinfrastructure. PLoS Comput Biol. 2017;13:e1005598.","journal-title":"PLoS Comput Biol"},{"key":"2011_CR30","doi-asserted-by":"publisher","first-page":"D380","DOI":"10.1093\/nar\/gkx1013","volume":"46","author":"H Han","year":"2018","unstructured":"Han H, Cho JW, Lee S, Yun A, Kim H, Bae D, Yang S, Kim CY, Lee M, Kim E, Lee S, Kang B, Jeong D, Kim Y, Jeon HN, Jung H, Nam S, Chung M, Kim JH, Lee I. TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res. 2018;46:D380\u20136.","journal-title":"Nucleic Acids Res"},{"key":"2011_CR31","doi-asserted-by":"publisher","first-page":"D115","DOI":"10.1093\/nar\/gkw1052","volume":"45","author":"Y Yi","year":"2017","unstructured":"Yi Y, Zhao Y, Li C, Zhang L, Huang H, Li Y, Liu L, Hou P, Cui T, Tan P, Hu Y, Zhang T, Huang Y, Li X, Yu J, Wang D. RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Res. 2017;45:D115\u20138.","journal-title":"Nucleic Acids Res"},{"key":"2011_CR32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/1074248415616187","volume":"21","author":"RA Kloner","year":"2016","unstructured":"Kloner RA, Dai W, Hale SL, Shi J. Approaches to Improving cardiac structure and function during and after an acute myocardial infarction: acute and chronic phases. J Cardiovasc Pharmacol Ther. 2016;21:363\u20137.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"2011_CR33","first-page":"1189","volume":"7","author":"P Grisel","year":"2011","unstructured":"Grisel P, Roffi M, Muller H, Keller PF. Mechanical complications of myocardial infarction. Rev Med Suisse Romande. 2011;7:1189\u201392.","journal-title":"Rev Med Suisse Romande"},{"key":"2011_CR34","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.resuscitation.2017.01.030","volume":"113","author":"J Silvain","year":"2017","unstructured":"Silvain J, Collet JP, Guedeney P, Varenne O, Nagaswami C, Maupain C, Empana JP, Boulanger C, Tafflet M, Manzo-Silberman S, Kerneis M, Brugier D, Vignolles N, Weisel JW, Jouven X, Montalescot G, Spaulding C. Thrombus composition in sudden cardiac death from acute myocardial infarction. Resuscitation. 2017;113:108\u201314.","journal-title":"Resuscitation"},{"key":"2011_CR35","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.117.027575","volume":"136","author":"S Pasupathy","year":"2017","unstructured":"Pasupathy S, Tavella R, Grover S, Raman B, Procter NEK, Du YT, Mahadavan G, Stafford I, Heresztyn T, Holmes A, Zeitz C, Arstall M, Selvanayagam J, Horowitz JD, Beltrame JF. Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-Segment-elevation myocardial infarction reduces myocardial infarct size (the NICAM Trial [N-acetylcysteine in Acute Myocardial Infarction]). Circulation. 2017;136:894\u2013903.","journal-title":"Circulation"},{"key":"2011_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bcp.2016.03.019","volume":"108","author":"H Yang","year":"2016","unstructured":"Yang H, Sun W, Quan N, Wang L, Chu D, Cates C, Liu Q, Zheng Y, Li J. Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway. Biochem Pharmacol. 2016;108:47\u201357.","journal-title":"Biochem Pharmacol"},{"key":"2011_CR37","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.numecd.2009.12.012","volume":"21","author":"V Boccardi","year":"2011","unstructured":"Boccardi V, Rizzo MR, Marfella R, Papa M, Esposito A, Portoghese M, Paolisso G, Barbieri M. 94 ins\/del ATTG NFKB1 gene variant is associated with lower susceptibility to myocardial infarction. Nutr Metab Cardiovasc Dis. 2011;21:679\u201384.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2011_CR38","doi-asserted-by":"publisher","first-page":"e88685","DOI":"10.1371\/journal.pone.0088685","volume":"9","author":"Y Feng","year":"2014","unstructured":"Feng Y, Huang W, Wani M, Yu X, Ashraf M. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS ONE. 2014;9:e88685.","journal-title":"PLoS ONE"},{"key":"2011_CR39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12933-015-0299-8","volume":"14","author":"M Ding","year":"2015","unstructured":"Ding M, Lei J, Han H, Li W, Qu Y, Fu E, Wang X. SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats. Cardiovasc Diabetol. 2015;14:143.","journal-title":"Cardiovasc Diabetol"},{"key":"2011_CR40","doi-asserted-by":"publisher","first-page":"14941","DOI":"10.1038\/ncomms14941","volume":"8","author":"G Yang","year":"2017","unstructured":"Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A. The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. Nat Commun. 2017;8:14941.","journal-title":"Nat Commun"},{"key":"2011_CR41","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12265-018-9839-4","volume":"12","author":"D Zhang","year":"2019","unstructured":"Zhang D, Wang B, Ma M, Yu K, Zhang Q, Zhang X. LncRNA HOTAIR protects myocardial infarction rat by sponging miR-519d-3p. J Cardiovasc Transl Res. 2019;12:171\u201383.","journal-title":"J Cardiovasc Transl Res"},{"key":"2011_CR42","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/j.biopha.2018.04.191","volume":"103","author":"N Jiang","year":"2018","unstructured":"Jiang N, Xia J, Jiang B, Xu Y, Li Y. TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells. Biomed Pharmacother. 2018;103:1669\u201377.","journal-title":"Biomed Pharmacother"},{"key":"2011_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.omtn.2018.01.010","volume":"11","author":"J Liu","year":"2018","unstructured":"Liu J, Jiang M, Deng S, Lu J, Huang H, Zhang Y, Gong P, Shen X, Ruan H, Jin M, Wang H. MiR-93-5p-containing exosomes treatment attenuates acute myocardial infarction-induced myocardial damage. Mol Ther Nucleic Acids. 2018;11:103\u201315.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"2011_CR44","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12933-019-0826-0","volume":"18","author":"FC Sasso","year":"2019","unstructured":"Sasso FC, Pafundi PC, Marfella R, et al. Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study. Cardiovasc Diabetol. 2019;18(1):24. https:\/\/doi.org\/10.1186\/s12933-019-0826-0.","journal-title":"Cardiovasc Diabetol"},{"issue":"8","key":"2011_CR45","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1210\/jc.2012-1364","volume":"97","author":"R Marfella","year":"2012","unstructured":"Marfella R, Sasso FC, Siniscalchi M, et al. Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction. J Clin Endocrinol Metab. 2012;97(8):2862\u201371. https:\/\/doi.org\/10.1210\/jc.2012-1364.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2011_CR46","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1210\/jc.2011-2037","volume":"97","author":"R Marfella","year":"2012","unstructured":"Marfella R, Sasso FC, Cacciapuoti F, et al. Tight glycemic control may increase regenerative potential of myocardium during acute infarction. J Clin Endocrinol Metab. 2012;97(3):933\u201342. https:\/\/doi.org\/10.1210\/jc.2011-2037.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2011_CR47","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1210\/jc.2010-1382","volume":"96","author":"R Marfella","year":"2011","unstructured":"Marfella R, Ferraraccio F, Rizzo MR, et al. Innate immune activity in plaque of patients with untreated and L-thyroxine-treated subclinical hypothyroidism. J Clin Endocrinol Metab. 2011;96(4):1015\u201320. https:\/\/doi.org\/10.1210\/jc.2010-1382.","journal-title":"J Clin Endocrinol Metab"},{"key":"2011_CR48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1475-2840-6-35","volume":"6","author":"R Marfella","year":"2007","unstructured":"Marfella R, D\u2019 Amico M, Di Filippo C, et al. The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes. Cardiovasc Diabetol. 2007;6:35. https:\/\/doi.org\/10.1186\/1475-2840-6-35.","journal-title":"Cardiovasc Diabetol."},{"issue":"2","key":"2011_CR49","doi-asserted-by":"publisher","first-page":"e000434","DOI":"10.1161\/JAHA.113.000434","volume":"3","author":"D Torella","year":"2014","unstructured":"Torella D, Ellison GM, Torella M, et al. Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy. J Am Heart Assoc. 2014;3(2):e000434. https:\/\/doi.org\/10.1161\/JAHA.113.000434.","journal-title":"J Am Heart Assoc."}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02011-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-021-02011-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02011-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T15:45:38Z","timestamp":1671896738000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-021-02011-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2011"],"URL":"https:\/\/doi.org\/10.1186\/s12872-021-02011-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-236756\/v1","asserted-by":"object"}]},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,20]]},"assertion":[{"value":"12 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All analyses were based on previous study, thus no ethical approval and patient consent are required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and patient consent"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"197"}}