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We aimed to determine the prevalence of the abnormal orthostatic blood pressure (BP) responses, and associated factors among diabetic individuals in ambulatory care for diabetes in southwestern Uganda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross-sectional study among diabetic individuals aged 18\u201365\u00a0years at Mbarara Regional Referral Hospital, southwestern Uganda from November 2018 to April 2019. We obtained demographic and clinical data including a detailed medical history, and glycemic profile. BP measurements were taken in supine position and within 3\u00a0min of standing. We defined OH in participants with either\u2009\u2265\u200920\u00a0mmHg drop in systolic BP (SBP) or\u2009\u2265\u200910\u00a0mmHg drop in diastolic BP (DBP) after assuming an upright position. OHT was defined in participants with either a\u2009\u2265\u200920\u00a0mmHg rise in SBP, or\u2009\u2265\u200910\u00a0mmHg rise in DBP after assuming an upright position. Multivariate logistic regression was used to identify factors associated with OH and OHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 299 participants, with a mean age of 50\u00a0years (SD\u2009\u00b1\u20099.8), and mean HbA1c of 9.7% (SD\u2009\u00b1\u20092.6); 70% were female. Of the 299 participants, 52 (17.4%; 95% CI 13.3\u201322.2%) met the definition of OH and 43 (14.4%; 95% CI 10.6\u201318.9%) were classified as having OHT. In multivariable models, factors associated with diabetic OH were older age (OR\u2009=\u20092.40 for 51\u201365\u00a0years vs 18\u201350\u00a0years, 95% CI 1.02\u20135.67,<jats:italic>P<\/jats:italic>\u2009=\u20090.046), diabetic retinopathy (OR\u2009=\u20092.51; 95% CI 1.14\u20135.53,<jats:italic>P<\/jats:italic>\u2009=\u20090.022), higher resting SBP\u2009\u2265\u2009140\u00a0mmHg (OR\u2009=\u20093.14; 95% CI 1.31\u20138.7.56,<jats:italic>P<\/jats:italic>\u2009=\u20090.011), and history of palpitations (OR\u2009=\u20092.31; 95% CI 1.08\u20134.92,<jats:italic>P<\/jats:italic>\u2009=\u20090.031). Self-report of palpitations (OR\u2009=\u20093.14; 95% CI 1.42\u20136.95,<jats:italic>P<\/jats:italic>\u2009=\u20090.005), and higher resting SBP\u2009\u2265\u2009140\u00a0mmHg (OR\u2009=\u200922.01; 95% CI 1.10\u20134.42,<jats:italic>P<\/jats:italic>\u2009=\u20090.043) were associated with OHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OH and OHT are common among diabetic individuals in ambulatory diabetes care in southwestern Uganda. Orthostatic BP measurements should be considered as part of routine physical examination to improve detection of OH and OHT, especially among older diabetics with complications of the disease. Future studies to assess the health and prognostic implications of OH and OHT among diabetics in the region are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12872-021-02022-5","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T09:21:39Z","timestamp":1619515299000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Postural changes in blood pressure among patients with diabetes attending a referral hospital in southwestern Uganda: a cross-sectional study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-9521","authenticated-orcid":false,"given":"Richard","family":"Migisha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Collins","family":"Agaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey","family":"Katamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Manne-Goehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Muyingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Siedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"issue":"2","key":"2022_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, et al. 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We also received approval for the study from the Uganda National Council of Science and Technology (UNCST) and from the Research Secretariat in the Office of the President of Uganda, in accordance with the national guidelines. All study participants provided written informed consent before participation. Participants who could not write gave consent with a thumbprint.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests in regard to this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"213"}}