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CA-IMT\u2009&gt;\u20091.0\u00a0mm was defined as abnormal IMT. Plaque stability was measured by ultrasound examination based on the property of the echo. And sdLDL-C levels were detected by LipoPrint system. Multivariate logistic regression analysis was performed to identify factors associated with CA-IMT and carotid plaque.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The abnormal IMT group had significantly higher sdLDL-C levels than control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). And sdLDL-C levels were significantly positively correlated with IMT value (r\u2009=\u20090.1396,<jats:italic>p<\/jats:italic>\u2009=\u20090.0021) and presence of carotid plaque (r\u2009=\u20090.14,<jats:italic>p<\/jats:italic>\u2009=\u20090.002) in the subjects with abnormal IMT. In addition, subjects with higher levels of sdLDL-C (r\u2009=\u20090.11,<jats:italic>p<\/jats:italic>\u2009=\u20090.035) tended to have unstable CAP. After adjustment for age, gender and blood glucose, sdLDL-C level was an independent risk factor of the presence of CAP (OR\u2009=\u20091.59, 95% CI: 1.02\u20131.83,<jats:italic>p<\/jats:italic>\u2009=\u20090.034) in subjects with abnormal IMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SdLDL-C is an independent risk factor of the occurrence of CAP in the Chinese subjects with abnormal IMT. Our findings provide supporting evidence that sdLDL-C might be an alternative way to predict CVD in early stage.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12872-021-02023-4","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T15:06:41Z","timestamp":1619536001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness"],"prefix":"10.1186","volume":"21","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"2023_CR1","doi-asserted-by":"crossref","unstructured":"Kavousi M, Elias-Smale S, Rutten Jh, Leening Mj, Vliegenthart R, Verwoert Gc, et al. 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