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This study aimed to evaluate the overall and sex-specific prognostic value of different geometric patterns on the incidence of stroke\/CHD and all-cause mortality in a Chinese population-based cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a prospective study in the general population in Northeast China, and a total of 9940 participants aged\u2009\u2265\u200935\u00a0years underwent echocardiography for LV geometry and were successfully followed up for incident stroke\/CHD and all-cause death. Cox proportional hazards models were utilized to estimate the association of baseline LV geometry with adverse outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Over a median follow-up of 4.66\u00a0years, abnormal LV geometric patterns had increased crude incident rates of stroke\/CHD and all-cause mortality compared with normal geometry in overall population and each sex group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariable Cox analysis reported that LV concentric and eccentric hypertrophy were associated with incident stroke\/CHD (concentric hypertrophy: hazard ratio (HR)\u2009=\u20091.39, 95% confidence interval (CI)\u2009=\u20091.04\u20131.86; eccentric hypertrophy: HR\u2009=\u20091.42, 95% CI\u2009=\u20091.11\u20131.82) and all-cause mortality (concentric hypertrophy: HR\u2009=\u20091.50, 95% CI\u2009=\u20091.07\u20132.12; eccentric hypertrophy: HR\u2009=\u20091.58, 95% CI\u2009=\u20091.19\u20132.10), and LV concentric remodeling was related to stroke\/CHD incidence (HR\u2009=\u20091.42, 95% CI\u2009=\u20091.09\u20131.84) in total population compared to normal geometry after the adjustment for potential confounders. In men, a significant increase was observed from LV eccentric hypertrophy for incident stroke\/CHD, whereas in women, LV concentric hypertrophy was associated with elevated incidence of both stroke\/CHD and all-cause death, and eccentric hypertrophy was correlated with increased all-cause mortality (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our prospective cohort supports that abnormal LV geometry by echocardiography has a prognostic significance for incident stroke\/CHD and all-cause mortality, implying that early detection and intervention of LV structural remodeling in rural China are urgently needed to prevent adverse outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-021-02055-w","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T08:03:47Z","timestamp":1620806627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Echocardiographic left ventricular geometry profiles for prediction of stroke, coronary heart disease and all-cause mortality in the Chinese community: a rural cohort population study"],"prefix":"10.1186","volume":"21","author":[{"given":"Tan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"7","key":"2055_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/heartjnl-2016-310052","volume":"103","author":"B Ambale-Venkatesh","year":"2017","unstructured":"Ambale-Venkatesh B, Yoneyama K, Sharma RK, Ohyama Y, Wu CO, Burke GL, Shea S, Gomes AS, Young AA, Bluemke DA, et al. 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All methods were performed in accordance with the relevant guidelines and regulations. Written informed consent was obtained from each participant. The decease patients are not involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"238"}}