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All patients were tested for HE4 levels at baseline and follow-up. Endpoints of the study included cardiovascular death and heart failure-related hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 96 patients with ICM were included for analysis. After a mean follow-up period of 263 (153\u2013313) days, cardiovascular events were observed in 45 patients. Serum HE4 levels in patients with events were significantly higher than those in patients without events [188.70 (113.35\u2013326.82) pmol\/L versus 92.90 (61.50\u2013123.20) pmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001]. Multivariate Cox regression analysis revealed that HE4 [\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      : 9.602, hazard ratio (HR): 1.003, 95% confidence interval (CI): 1.001\u20131.005,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002] and age [\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      : 4.55, HR: 1.044, 95% CI: 1.003\u20131.085,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033] were independent predictors of events. After adjusting for age and sex, the risk of events in patients with HE4\u2009&gt;\u2009100.2\u00a0pmol\/L was higher than that in patients with HE4\u2009\u2264\u2009100.2\u00a0pmol\/L [HR: 3.372, 95% CI: 1.409\u20138.065,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HE4 is an independent predictor of cardiovascular death and heart failure-related rehospitalization in patients with ICM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-021-02319-5","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T12:17:00Z","timestamp":1634818620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human epididymis protein 4: a novel predictor of ischemic cardiomyopathy"],"prefix":"10.1186","volume":"21","author":[{"given":"Yi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Yan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"issue":"15","key":"2319_CR1","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1053\/euhj.2000.2533","volume":"22","author":"A Mosterd","year":"2001","unstructured":"Mosterd A, Cost B, Hoes AW, de Bruijne MC, Deckers JW, Hofman A, Grobbee DE. 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This study was approved by the Ethics Committee of Hunan Provincial People's Hospital (2018-50). All individual subjects in this study provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"511"}}