{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:55:40Z","timestamp":1791492940328,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the National Key Research and Development Project","award":["2018YFA0800404"],"award-info":[{"award-number":["2018YFA0800404"]}]},{"name":"Natural Science Foundation and Key-Area Research and Development Program of Guangdong Province","award":["2018B030311031"],"award-info":[{"award-number":["2018B030311031"]}]},{"name":"Young Foundation of Fujian Provincial Education Department","award":["JAT170711"],"award-info":[{"award-number":["JAT170711"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970736"],"award-info":[{"award-number":["81970736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education","award":["LC2019ZD010"],"award-info":[{"award-number":["LC2019ZD010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Adipsin has been identified as a secreted adipokine that plays a critical pathogenic role in metabolic disorders. However, it is not clear regarding the association of circulating adipsin with cardiovascular disease (CVD). This study will explore the association between circulating adipsin and asymptomatic carotid atherosclerosis in Chinese obese adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 483 obese adult subjects (aged 40\u00a0years or older) were enrolled in this study. Serum adipsin concentrations and carotid intima-media thickness (CIMT) were measured to determine these associations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Individuals with increased CIMT and asymptomatic carotid atherosclerosis had lower levels of circulating adipsin than controls (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The prevalence of asymptomatic carotid atherosclerosis was significantly higher in subjects with lower levels of serum adipsin than those with higher values (42.5% vs. 36.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Notably, subjects in the lowest quartile of serum adipsin were 1.94 times (<jats:italic>p<\/jats:italic>\u2009=\u20090.059) more likely to have increased CIMT and 2.91 times (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) more likely to have asymptomatic carotid atherosclerosis than those in the highest quartile in multivariable logistic regression analyses, adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, and HOMA-IR. However, such associations with circulating adipsin were not noted for atherosclerotic plaque.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These findings suggest that circulating adipsin concentrations are a potential marker of risks of increased CIMT and asymptomatic carotid atherosclerosis in obese Chinese adults.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-021-02329-3","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T06:02:56Z","timestamp":1635141776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating adipsin is associated with asymptomatic carotid atherosclerosis in obese adults"],"prefix":"10.1186","volume":"21","author":[{"given":"Jinhua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"issue":"1","key":"2329_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1001\/archinternmed.2009.457","volume":"170","author":"S Smith","year":"2010","unstructured":"Smith S. Screening for high-risk cardiovascular disease: a challenge for the guidelines: comment on \u201csystematic review of guidelines on cardiovascular risk assessment: which recommendations should clinicians follow for a cardiovascular health check?\u201d Arch Internal Med. 2010;170(1):40\u20132.","journal-title":"Arch Internal Med"},{"issue":"1","key":"2329_CR2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.det.2014.09.004","volume":"33","author":"C Ryan","year":"2015","unstructured":"Ryan C, Kirby B. Psoriasis is a systemic disease with multiple cardiovascular and metabolic comorbidities. Dermatol Clin. 2015;33(1):41\u201355.","journal-title":"Dermatol Clin"},{"issue":"1","key":"2329_CR3","first-page":"1","volume":"14","author":"W Chen","year":"2017","unstructured":"Chen W, Gao R, Liu L, Zhu M-L, Wang W, Wang Y-J, et al. China cardiovascular diseases report 2015: a summary. J Geriatr Cardiol. 2017;14(1):1\u201310.","journal-title":"J Geriatr Cardiol"},{"issue":"9882","key":"2329_CR4","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/S0140-6736(13)61097-1","volume":"381","author":"G Yang","year":"2013","unstructured":"Yang G, Wang Y, Zeng Y, Gao GF, Liang X, Zhou M, et al. Rapid health transition in China, 1990\u20132010: findings from the Global Burden of Disease Study 2010. Lancet. 2013;381(9882):1987\u20132015.","journal-title":"Lancet"},{"issue":"1","key":"2329_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ahj.2008.08.016","volume":"157","author":"H Ni","year":"2009","unstructured":"Ni H, Coady S, Rosamond W, Folsom A, Chambless L, Russell S, et al. Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J. 2009;157(1):46\u201352.","journal-title":"Am Heart J"},{"issue":"25","key":"2329_CR6","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","volume":"56","author":"P Greenland","year":"2010","unstructured":"Greenland P, Alpert J, Beller G, Benjamin E, Budoff M, Fayad Z, et al. 2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56(25):e50-103.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2329_CR7","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.jadohealth.2010.09.001","volume":"48","author":"L Dietz","year":"2011","unstructured":"Dietz L, Matthews K. Depressive symptoms and subclinical markers of cardiovascular disease in adolescents. J Adolescent Health. 2011;48(6):579\u201384.","journal-title":"J Adolescent Health"},{"issue":"1","key":"2329_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1161\/CIRCULATIONAHA.106.645606","volume":"116","author":"J Cao","year":"2007","unstructured":"Cao J, Arnold A, Manolio T, Polak J, Psaty B, Hirsch C, et al. Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation. 2007;116(1):32\u20138.","journal-title":"Circulation"},{"issue":"25 Pt B","key":"2329_CR9","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1016\/j.jacc.2013.11.005","volume":"63","author":"DC Goff Jr","year":"2014","unstructured":"Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D\u2019Agostino RB Sr, Gibbons R, et al. 2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(25 Pt B):2935\u201359.","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"2329_CR10","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","volume":"288","author":"HM Lakka","year":"2002","unstructured":"Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709\u201316.","journal-title":"JAMA"},{"issue":"5","key":"2329_CR11","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.pcad.2016.01.008","volume":"58","author":"CJ Lavie","year":"2016","unstructured":"Lavie CJ, De Schutter A, Parto P, Jahangir E, Kokkinos P, Ortega FB, et al. Obesity and prevalence of cardiovascular diseases and prognosis-the obesity paradox updated. Prog Cardiovasc Dis. 2016;58(5):537\u201347.","journal-title":"Prog Cardiovasc Dis"},{"issue":"1","key":"2329_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","volume":"17","author":"V Ormazabal","year":"2018","unstructured":"Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17(1):122.","journal-title":"Cardiovasc Diabetol"},{"key":"2329_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fcvm.2020.00022","volume":"7","author":"A Chait","year":"2020","unstructured":"Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22.","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"2329_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","volume":"316","author":"S Galic","year":"2010","unstructured":"Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316(2):129\u201339.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"2329_CR15","doi-asserted-by":"publisher","first-page":"6184","DOI":"10.3390\/ijms15046184","volume":"15","author":"UJ Jung","year":"2014","unstructured":"Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014;15(4):6184\u2013223.","journal-title":"Int J Mol Sci"},{"key":"2329_CR16","doi-asserted-by":"crossref","unstructured":"Lee MW, Lee M, Oh KJ. Adipose tissue-derived signatures for obesity and type 2 diabetes: adipokines, batokines and microRNAs. J Clin Med. 2019;8(6).","DOI":"10.3390\/jcm8060854"},{"key":"2329_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bcp.2019.03.030","volume":"165","author":"V Francisco","year":"2019","unstructured":"Francisco V, Ruiz-Fernandez C, Pino J, Mera A, Gonzalez-Gay MA, Gomez R, et al. Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;165:196\u2013206.","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"2329_CR18","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","volume":"96","author":"AH Berg","year":"2005","unstructured":"Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96(9):939\u201349.","journal-title":"Circ Res"},{"issue":"9","key":"2329_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrendo.2017.56","volume":"13","author":"RCR Meex","year":"2017","unstructured":"Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat Rev Endocrinol. 2017;13(9):509\u201320.","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"2329_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","volume":"36","author":"M Fasshauer","year":"2015","unstructured":"Fasshauer M, Bl\u00fcher M. Adipokines in health and disease. Trends Pharmacol Sci. 2015;36(7):461\u201370.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"2329_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cell.2014.06.005","volume":"158","author":"JC Lo","year":"2014","unstructured":"Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, et al. Adipsin is an adipokine that improves beta cell function in diabetes. Cell. 2014;158(1):41\u201353.","journal-title":"Cell"},{"issue":"2","key":"2329_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0031-9384(93)90100-T","volume":"54","author":"J Miner","year":"1993","unstructured":"Miner J, Byatt J, Baile C, Krivi G. Adipsin expression and growth in rats as influenced by insulin and somatotropin. Physiol Behav. 1993;54(2):207\u201312.","journal-title":"Physiol Behav"},{"issue":"11","key":"2329_CR23","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1038\/s41591-019-0610-4","volume":"25","author":"N Gomez-Banoy","year":"2019","unstructured":"Gomez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, et al. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019;25(11):1739\u201347.","journal-title":"Nat Med"},{"issue":"2","key":"2329_CR24","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1210\/js.2018-00359","volume":"3","author":"JS Wang","year":"2019","unstructured":"Wang JS, Lee WJ, Lee IT, Lin SY, Lee WL, Liang KW, et al. Association between serum adipsin levels and insulin resistance in subjects with various degrees of glucose intolerance. J Endocr Soc. 2019;3(2):403\u201310.","journal-title":"J Endocr Soc"},{"issue":"1","key":"2329_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbrc.2016.07.095","volume":"478","author":"N Li","year":"2016","unstructured":"Li N, Zhao Y, Yue Y, Chen L, Yao Z, Niu W. Liraglutide ameliorates palmitate-induced endothelial dysfunction through activating AMPK and reversing leptin resistance. Biochem Biophys Res Commun. 2016;478(1):46\u201352.","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"2329_CR26","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.metabol.2015.06.003","volume":"64","author":"LL Pan","year":"2015","unstructured":"Pan LL, Zhang HJ, Huang ZF, Sun Q, Chen Z, Li ZB, et al. Intrahepatic triglyceride content is independently associated with chronic kidney disease in obese adults: a cross-sectional study. Metabolism. 2015;64(9):1077\u201385.","journal-title":"Metabolism"},{"key":"2329_CR27","doi-asserted-by":"publisher","first-page":"36710","DOI":"10.1038\/srep36710","volume":"6","author":"J Jiang","year":"2016","unstructured":"Jiang J, Lin M, Xu Y, Shao J, Li X, Zhang H, et al. Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults. Sci Rep. 2016;6:36710.","journal-title":"Sci Rep"},{"key":"2329_CR28","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.atherosclerosis.2018.12.005","volume":"282","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Evans MA, Allison MA, Bertoni AG, Budoff MJ, Criqui MH, et al. Multisite atherosclerosis in subjects with metabolic syndrome and diabetes and relation to cardiovascular events: the multi-ethnic study of atherosclerosis. Atherosclerosis. 2019;282:202\u20139.","journal-title":"Atherosclerosis"},{"issue":"4911","key":"2329_CR29","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.2734615","volume":"244","author":"B Rosen","year":"1989","unstructured":"Rosen B, Cook K, Yaglom J, Groves D, Volanakis J, Damm D, et al. Adipsin and complement factor D activity: an immune-related defect in obesity. Science. 1989;244(4911):1483\u20137.","journal-title":"Science"},{"issue":"8","key":"2329_CR30","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.metabol.2015.11.006","volume":"65","author":"SA Polyzos","year":"2016","unstructured":"Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease. Metabolism. 2016;65(8):1062\u201379.","journal-title":"Metabolism"},{"issue":"1","key":"2329_CR31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1006\/prep.2001.1482","volume":"23","author":"J Miner","year":"2001","unstructured":"Miner J, Hahn K, Spurlock M, Staten NJ. Expression and complement d activity of porcine adipsin. Protein Expr Purif. 2001;23(1):14\u201321.","journal-title":"Protein Expr Purif"},{"issue":"1","key":"2329_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1590\/2359-3997000000147","volume":"60","author":"I Legakis","year":"2016","unstructured":"Legakis I, Mantzouridis T, Bouboulis G, Chrousos GP. Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast. Arch Endocrinol Metab. 2016;60(1):76\u20138.","journal-title":"Arch Endocrinol Metab"},{"key":"2329_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12986-017-0185-3","volume":"14","author":"W Liu","year":"2017","unstructured":"Liu W, Jiang L, Chen J, Gao C, Zhou J, Zhou J, et al. Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study. Nutr Metab. 2017;14:34.","journal-title":"Nutr Metab"},{"issue":"6","key":"2329_CR34","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/cen.13157","volume":"85","author":"O Gursoy Calan","year":"2016","unstructured":"Gursoy Calan O, Calan M, Yesil Senses P, Unal Kocabas G, Ozden E, Sari KR, et al. Increased adipsin is associated with carotid intima media thickness and metabolic disturbances in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2016;85(6):910\u20137.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2329_CR35","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1007\/s10753-013-9620-4","volume":"36","author":"G Derosa","year":"2013","unstructured":"Derosa G, Fogari E, D\u2019Angelo A, Bianchi L, Bonaventura A, Romano D, et al. Adipocytokine levels in obese and non-obese subjects: an observational study. Inflammation. 2013;36(4):914\u201320.","journal-title":"Inflammation"},{"issue":"4","key":"2329_CR36","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ana.22669","volume":"71","author":"C Prugger","year":"2012","unstructured":"Prugger C, Luc G, Haas B, Arveiler D, Machez E, Ferrieres J, et al. Adipocytokines and the risk of ischemic stroke: the PRIME Study. Ann Neurol. 2012;71(4):478\u201386.","journal-title":"Ann Neurol"},{"issue":"8","key":"2329_CR37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.nutres.2012.06.015","volume":"32","author":"S Sole","year":"2012","unstructured":"Sole S, Srinivasan B. Aqueous extract of tamarind seeds selectively increases glucose transporter-2, glucose transporter-4, and islets\u2019 intracellular calcium levels and stimulates \u03b2-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes mellitus. Nutr Res. 2012;32(8):626\u201336.","journal-title":"Nutr Res"},{"issue":"3","key":"2329_CR38","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0378-8741(01)00254-9","volume":"76","author":"S Singh","year":"2001","unstructured":"Singh S, Vats P, Suri S, Shyam R, Kumria M, Ranganathan S, et al. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharmacol. 2001;76(3):269\u201377.","journal-title":"J Ethnopharmacol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02329-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-021-02329-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02329-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T06:04:42Z","timestamp":1635141882000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-021-02329-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2329"],"URL":"https:\/\/doi.org\/10.1186\/s12872-021-02329-3","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"19 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All subjects provided written informed consent. The study protocol was approved by the Institutional Review Board of the First Affiliated Hospital of Xiamen University and Nanfang Hospital of Southern Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patients gave written informed consent for clinical data use and for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declares that there is no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"517"}}