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Although recent studies have increased awareness that PH contributes significantly to the high morbidity and mortality of BPD, the risk factors and clinical characteristics for PH in VLBWIs are little known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the risk factors and clinical characteristics for BPD-associated pulmonary hypertension (BPD-PH) in VLBWIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2013control observational study of VLBWIs with BPD admitted to a neonatal intensive care unit (NICU) over 4\u00a0years. According to echocardiograms confirming elevated pulmonary artery pressure after 28\u00a0days after birth, we divided BPD infants into PH group (n\u2009=\u200918) and non-PH group (n\u2009=\u200965). We compared pre- and postnatal characteristics between VLBWIs with or without PH. Multivariable logistic regression analysis was conducted with backward selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 83 infants with BPD were divided into PH group (n\u2009=\u200918) or non-PH group (n\u2009=\u200965). The average birth weight of the infants with BPD was 1078.1\u00a0g. Compared with those infants of the non-PH group, the birth weight of BPD-PH infants was significantly lower (968.1\u2009\u00b1\u2009187.7 vs. 1108.5\u2009\u00b1\u2009185.8,<jats:italic>P<\/jats:italic>\u2009=\u20090.006). Infants in the PH group had a higher incidence of patent ductus arteriosus (PDA) and underwent longer durations of oxygen therapy and mechanical ventilation compared to those in the non-PH group. In all subjects, birth weight (OR 0.995; 95% CI 0.991\u20130.999;<jats:italic>P<\/jats:italic>\u2009=\u20090.025) and PDA (OR 13.355; 95% CI 2.950\u201360.469;<jats:italic>P<\/jats:italic>\u2009=\u20090.001) were found to be specific risk factors for BPD-PH in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study shows PDA and birth weight are specific risk factors for BPD-PH in VLBWIs.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12872-021-02330-w","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T10:02:39Z","timestamp":1635069759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors and clinical characteristics for bronchopulmonary dysplasia associated pulmonary hypertension in very-low-birth-weight infants"],"prefix":"10.1186","volume":"21","author":[{"given":"Junfang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"issue":"9607","key":"2330_CR1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0140-6736(08)60108-7","volume":"371","author":"JD Iams","year":"2008","unstructured":"Iams JD, Romero R, Culhane JF, Goldenberg RL. 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There is no need to recruit subjects, and the informed consent of previous subjects cannot be obtained objectively. This study does not involve personal privacy. The Ethics Committee of Shanghai Children's Hospital has approved the waiver of informed consent. The study protocol was approved by Ethics Committee of Shanghai Children\u2019s Hospital (2015RY009-F01), all methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"514"}}