{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:33:16Z","timestamp":1791304396444,"version":"4.3.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Project of Scientific research of Hebei Provincial Administration of Traditional Chinese Medicine","award":["2019134"],"award-info":[{"award-number":["2019134"]}]},{"name":"the Project of Scientific research of Hebei Provincial Administration of Traditional Chinese Medicine","award":["2019134"],"award-info":[{"award-number":["2019134"]}]},{"name":"the Project of Scientific research of Hebei Provincial Administration of Traditional Chinese Medicine","award":["2019134"],"award-info":[{"award-number":["2019134"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included and followed up. The data covered the basic clinical features, imaging findings, treatments and prognosis of patients with MPE, and the factors that may have affected the prognosis were explored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 216 patients with MPE were included with the median age of 60\u00a0years. The most common primary cancer type was lung cancer (73.6%), the most common symptom was dyspnea (62.9%) and the most common abnormal electrocardiogram finding was sinus tachycardia (42.1%). The median survival time of the 216 patients with MPE was 13.7\u00a0months. The factors affecting prognosis were echocardiographic fluid signs (<jats:italic>HR<\/jats:italic>\u2009=\u20092.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.010), electrocardiographic evidence of sinus tachycardia (<jats:italic>HR<\/jats:italic>\u2009=\u20091.76, <jats:italic>P<\/jats:italic>\u2009=\u20090.006) and echocardiographic evidence of cardiac tamponade (<jats:italic>HR<\/jats:italic>\u2009=\u20093.33, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MPE has complex clinical manifestations and an unsatisfactory prognosis. Echocardiographic fluid signs, electrocardiographic evidence of sinus tachycardia, and echocardiographic evidence of cardiac tamponade are independent risk factors affecting prognosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-021-02331-9","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T18:02:22Z","timestamp":1637949742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China"],"prefix":"10.1186","volume":"21","author":[{"given":"Shucai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"issue":"3","key":"2331_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s11739-015-1372-8","volume":"11","author":"E Ceriani","year":"2016","unstructured":"Ceriani E, Cogliati C. Update on bedside ultrasound diagnosis of pericardial effusion. Intern Emerg Med. 2016;11(3):477\u201380.","journal-title":"Intern Emerg Med"},{"key":"2331_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.amjcard.2020.12.092","volume":"145","author":"J Chahine","year":"2021","unstructured":"Chahine J, Shekhar S, Mahalwar G, Imazio M, Collier P, Klein A. Pericardial involvement in cancer. Am J Cardiol. 2021;145:151\u20139.","journal-title":"Am J Cardiol"},{"key":"2331_CR3","doi-asserted-by":"crossref","unstructured":"Carasso S, Grosman-Rimon L, Nassar A, Kusniec F, Ghanim D, Elbaz-Greener G, et al. Serum BNP levels are associated with malignant pericardial effusion. Int J Cardiol Heart Vasc. 2019;23:100359.","DOI":"10.1016\/j.ijcha.2019.100359"},{"key":"2331_CR4","doi-asserted-by":"crossref","unstructured":"Han P, Yao R, Zhai D, Cheng C, Yang F, Sun S, et al. A case report of lung adenocarcinoma with polyserous effusions as the onset symptom. Medicine (Baltimore). 2017; 96(36):e7867.","DOI":"10.1097\/MD.0000000000007867"},{"issue":"4","key":"2331_CR5","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0733-8651(18)30339-4","volume":"8","author":"EW Hancock","year":"1990","unstructured":"Hancock EW. Neoplastic pericardial disease. Cardiol Clin. 1990;8(4):673\u201382.","journal-title":"Cardiol Clin"},{"issue":"4","key":"2331_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000348559","volume":"124","author":"I Burazor","year":"2013","unstructured":"Burazor I, Imazio M, Markel G, Adler Y. Malignant pericardial effusion. Cardiology. 2013;124(4):224\u201332.","journal-title":"Cardiology"},{"issue":"11","key":"2331_CR7","first-page":"741","volume":"97","author":"ML Higdon","year":"2018","unstructured":"Higdon ML, Atkinson CJ, Lawrence KV. Oncologic emergencies: recognition and initial management. Am Fam Phys. 2018;97(11):741\u20138.","journal-title":"Am Fam Phys"},{"issue":"5","key":"2331_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11748-018-0912-3","volume":"66","author":"S Taguchi","year":"2018","unstructured":"Taguchi S. Comprehensive review of the epidemiology and treatments for malignant adult cardiac tumors. Gen Thorac Cardiovasc Surg. 2018;66(5):257\u201362.","journal-title":"Gen Thorac Cardiovasc Surg"},{"issue":"7","key":"2331_CR9","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1097\/CCM.0b013e31824e1865","volume":"40","author":"MT McCurdy","year":"2012","unstructured":"McCurdy MT, Shanholtz CB. Oncologic emergencies. Crit Care Med. 2012;40(7):2212\u201322.","journal-title":"Crit Care Med"},{"issue":"10","key":"2331_CR10","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/clc.20936","volume":"34","author":"MM Refaat","year":"2011","unstructured":"Refaat MM, Katz WE. Neoplastic pericardial effusion. Clin Cardiol. 2011;34(10):593\u20138.","journal-title":"Clin Cardiol"},{"key":"2331_CR11","doi-asserted-by":"crossref","unstructured":"Verlaan D, Veltman JD, Grady B. Total electrical alternans in a patient with malignant pericardial tamponade. BMJ Case Rep. 2018;2018.","DOI":"10.1136\/bcr-2018-224771"},{"issue":"8","key":"2331_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/SMJ.0b013e3182a1456c","volume":"106","author":"M Goyal","year":"2013","unstructured":"Goyal M, Woods KM, Atwood JE. Electrical alternans: a sign, not a diagnosis. South Med J. 2013;106(8):485\u20139.","journal-title":"South Med J"},{"issue":"3","key":"2331_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/clc.22370","volume":"38","author":"RG Argula","year":"2015","unstructured":"Argula RG, Negi SI, Banchs J, Yusuf SW. Role of a 12-lead electrocardiogram in the diagnosis of cardiac tamponade as diagnosed by transthoracic echocardiography in patients with malignant pericardial effusion. Clin Cardiol. 2015;38(3):139\u201344.","journal-title":"Clin Cardiol"},{"issue":"7","key":"2331_CR14","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/clc.22416","volume":"38","author":"N Khalid","year":"2015","unstructured":"Khalid N, Chhabra L, Spodick DH. Response to role of a 12-lead electrocardiogram in the diagnosis of cardiac tamponade as diagnosed by transthoracic echocardiography in patients with malignant pericardial effusion. Clin Cardiol. 2015;38(7):445\u20136.","journal-title":"Clin Cardiol"},{"issue":"9","key":"2331_CR15","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1111\/echo.13620","volume":"34","author":"G Chalikias","year":"2017","unstructured":"Chalikias G, Samaras A, Ziakas A, Kikas P, Thomaidis A, Drosos I, et al. Novel echocardiographic prognostic markers for cardiac tamponade in patients with large malignant pericardial effusions: a paradigm shift from flow to tissue imaging. Echocardiography. 2017;34(9):1315\u201323.","journal-title":"Echocardiography"},{"issue":"4","key":"2331_CR16","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3348\/kjr.2016.17.4.545","volume":"17","author":"YK Kim","year":"2016","unstructured":"Kim YK, Kim JS, Lee KW, Yi CA, Goo JM, Jung SH. Multidetector CT findings and differential diagnoses of malignant pleural mesothelioma and metastatic pleural diseases in Korea. Korean J Radiol. 2016;17(4):545\u201353.","journal-title":"Korean J Radiol"},{"issue":"1","key":"2331_CR17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.rcl.2018.09.001","volume":"57","author":"S Kligerman","year":"2019","unstructured":"Kligerman S. Imaging of pericardial disease. Radiol Clin North Am. 2019;57(1):179\u201399.","journal-title":"Radiol Clin North Am"},{"issue":"4","key":"2331_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1586\/14779072.2015.1025754","volume":"13","author":"C Lestuzzi","year":"2015","unstructured":"Lestuzzi C, Berretta M, Tomkowski W. 2015 update on the diagnosis and management of neoplastic pericardial disease. Exp Rev Cardiovasc Ther. 2015;13(4):377\u201389.","journal-title":"Exp Rev Cardiovasc Ther"},{"issue":"8","key":"2331_CR19","doi-asserted-by":"publisher","first-page":"300060520937490","DOI":"10.1177\/0300060520937490","volume":"48","author":"Z Cai","year":"2020","unstructured":"Cai Z, Yao Y. Reduction of pericardial effusion in advanced non-small cell lung cancer patients with KRAS, TP53, and MET mutation treated with nivolumab. J Int Med Res. 2020;48(8):300060520937490.","journal-title":"J Int Med Res"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02331-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-021-02331-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-021-02331-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T18:02:40Z","timestamp":1637949760000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-021-02331-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2331"],"URL":"https:\/\/doi.org\/10.1186\/s12872-021-02331-9","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"7 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study complied with the Declaration of Helsinki and was approved by the Ethics Committee of the Fourth Hospital of Hebei Medical University (2013-KY1079). Each participant signed an informed consent form and agreed to the publication and dissemination of all forms of data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"565"}}