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However, its effects on prognosis are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 151 consecutive patients with AF and functional MR, 82 (54.3%) of whom were treated by catheter ablation (Ablation group) and 69 (45.7%) with drug therapy without ablation (Non-ablation group). Forty-three pairs of these patients were propensity matched on the basis of age, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc scores, and left ventricular ejection fraction. The primary outcome evaluated was severity of MR, cardiac remodeling and the combined incidence of subsequent heart failure-related hospitalization and strokes\/transient ischemic attacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the Ablation group showed a significant decrease in the severity of MR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), a significant decrease in the left atrial diameter (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), and significant improvement in the left ventricular ejection fraction (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). However, patients in the Non-ablation group showed only a significant decrease in the severity of MR (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). The annual incidence of the studied events was 4.9% in the Ablation group and 16.7% in the Non-ablation group, the incidence being significantly lower in the ablation than Non-ablation group (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) according to Kaplan\u2013Meier curve analyses. According to multivariate Cox regression analysis, catheter ablation therapy (hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.09\u20130.84;<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and heart failure at baseline (HR 3.84, 95% CI 1.07\u201313.74;<jats:italic>p<\/jats:italic>\u2009=\u20090.038) were independent predictors of the incidence of the studied events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with AF and functional MR, catheter ablation was associated with a significantly lower combined risk of heart failure-related hospitalization and stroke than in a matched cohort of patients receiving drug therapy alone.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12872-021-02397-5","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T12:03:26Z","timestamp":1638878606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of catheter ablation on clinical outcomes in patients with atrial fibrillation and significant functional mitral regurgitation"],"prefix":"10.1186","volume":"21","author":[{"given":"Jin-Tao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jie","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"issue":"4","key":"2397_CR1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.jcmg.2017.09.013","volume":"12","author":"DH Kim","year":"2019","unstructured":"Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, et al. 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