{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:40:01Z","timestamp":1771472401735,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004359","name":"vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["ALF 73400"],"award-info":[{"award-number":["ALF 73400"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["ALFGBG-717211"],"award-info":[{"award-number":["ALFGBG-717211"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02527"],"award-info":[{"award-number":["2018-02527"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VRREG 2019-00193"],"award-info":[{"award-number":["VRREG 2019-00193"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"hj\u00e4rt-lungfonden","doi-asserted-by":"publisher","award":["2018-0366"],"award-info":[{"award-number":["2018-0366"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"v\u00e4stra g\u00f6talandsregionen","doi-asserted-by":"publisher","award":["FOU-VGR"],"award-info":[{"award-number":["FOU-VGR"]}],"id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"g\u00f6teborgs l\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","award":["20\/935037"],"award-info":[{"award-number":["20\/935037"]}],"id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acquired aortic stenosis (AS) increases with age and has high mortality without intervention. Factors predicting its development are unclear, although atherosclerotic factors are assumed to be involved. Our aim in this study is to estimate the lifetime cumulative incidence and predictors of AS in middle-aged men.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included a random sample of men (n\u2009=\u20099998) born 1915\u20131925 in Gothenburg, Sweden. From them, 7,494 were examined and followed until a diagnosis of AS or death (maximum follow-up time 42.8\u00a0years). We identified AS diagnosis from the Swedish National Patient Registry and deaths from the Swedish Cause of Death Registry by using International Classification of Disease (ICD) diagnostic criteria. To study time-dependent relationships between AS and risk factors with death as the competing risk, we divided the cohort into three overlapping follow-up groups: 25\u201343, 30\u201343 and 35\u201343\u00a0years. We used age-adjusted Cox proportional hazards model to identify predictors of AS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The lifelong cumulative incidence of AS was 3.2%. At baseline, participants in the third group had a healthier lifestyle, lower body mass index (BMI), blood pressure, and serum cholesterol levels. Higher BMI, obesity, cholesterol, hypertension, atrial fibrillation, smoking and heredity for stroke were associated with AS. With BMI of 20\u201322.5 as a reference, hazard ratios of being diagnosed with AS for men with a baseline BMI of 25\u201327.5\u00a0kg\/m<jats:sup>2<\/jats:sup>, 27.5\u201330\u00a0kg\/m<jats:sup>2<\/jats:sup> and\u2009&gt;\u200930\u00a0kg\/m<jats:sup>2<\/jats:sup> were 1.99 (95% CI 1.12\u20133.55), 2.98 (95% CI 1.65\u20135.40) and 3.55 (95% CI 1.84\u20136.87), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The lifetime cumulative incidence of AS in middle-aged male population was 3.2%. Multiple atherosclerotic risk factors, particularly high BMI might be associated with a higher risk of developing AS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02487-y","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:02:28Z","timestamp":1644786148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cumulative incidence and predictors of acquired aortic stenosis in a large population of men followed for up to 43\u00a0years"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-8208","authenticated-orcid":false,"given":"Silvana","family":"Kontogeorgos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Thunstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Lappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"issue":"6","key":"2487_CR1","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","volume":"99","author":"GW Eveborn","year":"2013","unstructured":"Eveborn GW, Schirmer H, Heggelund G, Lunde P, Rasmussen K. The evolving epidemiology of valvular aortic stenosis. The Tromso study. Heart. 2013;99(6):396\u2013400.","journal-title":"Heart"},{"key":"2487_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/eurheartj\/9.suppl_E.57","volume":"9","author":"D Horstkotte","year":"1988","unstructured":"Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J. 1988;9:57\u201364.","journal-title":"Eur Heart J"},{"issue":"2","key":"2487_CR3","first-page":"844","volume":"90","author":"CM Otto","year":"1994","unstructured":"Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O\u2019Brien KD. Characterization of the early lesion of \u201cdegenerative\u201d valvular aortic stenosis. Histol Immunohistochem Stud Circ. 1994;90(2):844\u201353.","journal-title":"Histol Immunohistochem Stud Circ"},{"issue":"1","key":"2487_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0002-9149(02)03010-2","volume":"91","author":"M Peltier","year":"2003","unstructured":"Peltier M, Trojette F, Sarano ME, Grigioni F, Slama MA, Tribouilloy CM. Relation between cardiovascular risk factors and nonrheumatic severe calcific aortic stenosis among patients with a three-cuspid aortic valve. Am J Cardiol. 2003;91(1):97\u20139.","journal-title":"Am J Cardiol"},{"issue":"2","key":"2487_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jacc.2019.10.050","volume":"75","author":"M Kaltoft","year":"2020","unstructured":"Kaltoft M, Langsted A, Nordestgaard BG. Obesity as a causal risk factor for aortic valve stenosis. J Am Coll Cardiol. 2020;75(2):163\u201376.","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"2487_CR6","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","volume":"69","author":"AT Yan","year":"2017","unstructured":"Yan AT, Koh M, Chan KK, Guo H, Alter DA, Austin PC, et al. Association between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study. J Am Coll Cardiol. 2017;69(12):1523\u201332.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2487_CR7","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","volume":"29","author":"BF Stewart","year":"1997","unstructured":"Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol. 1997;29(3):630\u20134.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2487_CR8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1161\/01.ATV.0000255952.47980.c2","volume":"27","author":"D Messika-Zeitoun","year":"2007","unstructured":"Messika-Zeitoun D, Bielak LF, Peyser PA, Sheedy PF, Turner ST, Nkomo VT, et al. Aortic valve calcification: determinants and progression in the population. Arterioscler Thromb Vasc Biol. 2007;27(3):642\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"2487_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0021-9681(84)90108-5","volume":"37","author":"S Deutscher","year":"1984","unstructured":"Deutscher S, Rockette HE, Krishnaswami V. Diabetes and hypercholesterolemia among patients with calcific aortic stenosis. J Chronic Dis. 1984;37(5):407\u201315.","journal-title":"J Chronic Dis"},{"issue":"7","key":"2487_CR10","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/oxfordjournals.eurheartj.a060602","volume":"15","author":"M Lindroos","year":"1994","unstructured":"Lindroos M, Kupari M, Valvanne J, Strandberg T, Heikkila J, Tilvis R. Factors associated with calcific aortic valve degeneration in the elderly. Eur Heart J. 1994;15(7):865\u201370.","journal-title":"Eur Heart J"},{"issue":"2","key":"2487_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/14017431.2019.1605094","volume":"53","author":"J Ljungberg","year":"2019","unstructured":"Ljungberg J, Johansson B, Engstr\u00f6m KG, Norberg M, Bergdahl IA, S\u00f6derberg S. Arterial hypertension and diastolic blood pressure associate with aortic stenosis. Scand Cardiovasc J. 2019;53(2):91\u20137.","journal-title":"Scand Cardiovasc J"},{"issue":"2","key":"2487_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/14017431.2019.1685126","volume":"54","author":"S Kontogeorgos","year":"2020","unstructured":"Kontogeorgos S, Thunstr\u00f6m E, Basic C, Hansson PO, Zhong Y, Ergatoudes C, et al. Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men. Scand Cardiovasc J. 2020;54(2):115\u201323.","journal-title":"Scand Cardiovasc J"},{"key":"2487_CR13","unstructured":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization technical report series. 2000;894:i\u2013xii, 1\u2013253."},{"issue":"5","key":"2487_CR14","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/01.ATV.0000216787.85457.f3","volume":"26","author":"P Poirier","year":"2006","unstructured":"Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol. 2006;26(5):968\u201376.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"18","key":"2487_CR15","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.jacc.2013.04.081","volume":"62","author":"BP Rogge","year":"2013","unstructured":"Rogge BP, Cramariuc D, Lonnebakken MT, Gohlke-Barwolf C, Chambers JB, Boman K, et al. Effect of overweight and obesity on cardiovascular events in asymptomatic aortic stenosis: a SEAS substudy (Simvastatin Ezetimibe in Aortic Stenosis). J Am Coll Cardiol. 2013;62(18):1683\u201390.","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"2487_CR16","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1001\/archinte.162.16.1867","volume":"162","author":"PW Wilson","year":"2002","unstructured":"Wilson PW, D\u2019Agostino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162(16):1867\u201372.","journal-title":"Arch Intern Med"},{"issue":"3","key":"2487_CR17","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0002-9149(77)80104-5","volume":"39","author":"SW Rabkin","year":"1977","unstructured":"Rabkin SW, Mathewson FA, Hsu PH. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. Am J Cardiol. 1977;39(3):452\u20138.","journal-title":"Am J Cardiol"},{"key":"2487_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12872-015-0008-2","volume":"15","author":"L Bjorck","year":"2015","unstructured":"Bjorck L, Novak M, Schaufelberger M, Giang KW, Rosengren A. Body weight in midlife and long-term risk of developing heart failure-a 35-year follow-up of the primary prevention study in Gothenburg, Sweden. BMC Cardiovasc Disord. 2015;15:19.","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"2487_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/oxfordjournals.eurheartj.a062065","volume":"7","author":"L Wilhelmsen","year":"1986","unstructured":"Wilhelmsen L, Berglund G, Elmfeldt D, Tibblin G, Wedel H, Pennert K, et al. The multifactor primary prevention trial in Goteborg, Sweden. Eur Heart J. 1986;7(4):279\u201388.","journal-title":"Eur Heart J"},{"key":"2487_CR20","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing; 2019."},{"issue":"9540","key":"2487_CR21","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","volume":"368","author":"VT Nkomo","year":"2006","unstructured":"Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005\u201311.","journal-title":"Lancet"},{"issue":"5","key":"2487_CR22","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/0735-1097(93)90249-Z","volume":"21","author":"M Lindroos","year":"1993","unstructured":"Lindroos M, Kupari M, Heikkila J, Tilvis R. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21(5):1220\u20135.","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"2487_CR23","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1016\/j.jacc.2007.07.064","volume":"50","author":"GM Novaro","year":"2007","unstructured":"Novaro GM, Katz R, Aviles RJ, Gottdiener JS, Cushman M, Psaty BM, et al. Clinical factors, but not C-reactive protein, predict progression of calcific aortic-valve disease: the Cardiovascular Health Study. J Am Coll Cardiol. 2007;50(20):1992\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"28","key":"2487_CR24","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1093\/eurheartj\/ehx140","volume":"38","author":"SC Larsson","year":"2017","unstructured":"Larsson SC, Wolk A, Hakansson N, Back M. Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies. Eur Heart J. 2017;38(28):2192\u20137.","journal-title":"Eur Heart J"},{"issue":"5","key":"2487_CR25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.amjcard.2009.10.071","volume":"105","author":"DS Owens","year":"2010","unstructured":"Owens DS, Katz R, Takasu J, Kronmal R, Budoff MJ, O\u2019Brien KD. Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA). Am J Cardiol. 2010;105(5):701\u20138.","journal-title":"Am J Cardiol"},{"issue":"22","key":"2487_CR26","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1016\/j.jacc.2010.03.019","volume":"55","author":"G Thanassoulis","year":"2010","unstructured":"Thanassoulis G, Massaro JM, Cury R, Manders E, Benjamin EJ, Vasan RS, et al. Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010;55(22):2491\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2487_CR27","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/00019501-200509000-00007","volume":"16","author":"Y Aksoy","year":"2005","unstructured":"Aksoy Y, Yagmur C, Tekin GO, Yagmur J, Topal E, Kekilli E, et al. Aortic valve calcification: association with bone mineral density and cardiovascular risk factors. Coron Artery Dis. 2005;16(6):379\u201383.","journal-title":"Coron Artery Dis"},{"issue":"2","key":"2487_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1076-7460.2001.00839.x","volume":"10","author":"MV Ngo","year":"2001","unstructured":"Ngo MV, Gottdiener JS, Fletcher RD, Fernicola DJ, Gersh BJ. Smoking and obesity are associated with the progression of aortic stenosis. Am J Geriatr Cardiol. 2001;10(2):86\u201390.","journal-title":"Am J Geriatr Cardiol"},{"issue":"11","key":"2487_CR29","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1016\/j.jacc.2005.12.073","volume":"47","author":"M Briand","year":"2006","unstructured":"Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Despr\u00e9s J-P, et al. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis. J Am Coll Cardiol. 2006;47(11):2229\u201336.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2487_CR30","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jacc.2012.03.052","volume":"60","author":"R Capoulade","year":"2012","unstructured":"Capoulade R, Clavel M-A, Dumesnil JG, Chan KL, Teo KK, Tam JW, et al. Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy. J Am Coll Cardiol. 2012;60(3):216\u201323.","journal-title":"J Am Coll Cardiol"},{"key":"2487_CR31","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","volume":"29","author":"MF Gregor","year":"2011","unstructured":"Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415\u201345.","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"2487_CR32","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/eci.12169","volume":"43","author":"R Capoulade","year":"2013","unstructured":"Capoulade R, Clavel MA, Mathieu P, C\u00f4t\u00e9 N, Dumesnil JG, Arsenault M, et al. Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis. Eur J Clin Investig. 2013;43(12):1262\u201372.","journal-title":"Eur J Clin Investig"},{"issue":"1","key":"2487_CR33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/HYPERTENSIONAHA.112.202697","volume":"61","author":"S Iwata","year":"2013","unstructured":"Iwata S, Russo C, Jin Z, Schwartz JE, Homma S, Elkind MS, et al. Higher ambulatory blood pressure is associated with aortic valve calcification in the elderly: a population-based study. Hypertension (Dallas, Tex: 1979). 2013;61(1):55\u201360.","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"issue":"3","key":"2487_CR34","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jacc.2018.10.068","volume":"73","author":"G Vavilis","year":"2019","unstructured":"Vavilis G, B\u00e4ck M, Occhino G, Trevisan M, Bellocco R, Evans M, et al. Kidney Dysfunction and the Risk of Developing Aortic Stenosis. J Am Coll Cardiol. 2019;73(3):305\u201314.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2487_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0091-7435(72)90082-5","volume":"1","author":"L Wilhelmsen","year":"1972","unstructured":"Wilhelmsen L, Tibblin G, Werk\u00f6 L. A primary preventive study of Gothenburg. Sweden Prev Med. 1972;1(1):153\u201360.","journal-title":"Sweden Prev Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-022-02487-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-022-02487-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-022-02487-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:03:19Z","timestamp":1644786199000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-022-02487-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,13]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2487"],"URL":"https:\/\/doi.org\/10.1186\/s12872-022-02487-y","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,13]]},"assertion":[{"value":"8 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In this study, initiated over 50\u00a0years ago, participant consent was considered implicit on attending the screening investigation, written consent was not a requirement from the ethics committee, and the subsequent interventions were carried out as part of clinical management of high risk individuals. The men in the control group were never contacted, only followed through local and national registries []. However, the process of running the data file of the participants against the Swedish National Patient Registry and the Swedish Cause of Death Registry was approved by the Ethical Committee at the University of Gothenburg (886-13, T187-16). The study complied with the Declaration of Helsinki issued 1974.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors read and approved the final version of the manuscript, and approved the submitted manuscript and the submission for potential publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}