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Cutting balloon (CB) has been widely used for HCLs, but patients\u2019 prognosis had not been fully clarified. The study aimed to compare 3-year clinical outcomes between patients with HCLs that are treated with CBs and those with non-HCLs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Patients who underwent PCI in Guizhou Provincial People\u2019s Hospital from June 2015 to September 2018 were retrospectively included. HCL was defined as radiopaque and high-pressure undilatable lesions. CBs were routinely used in combination with non-compliant balloons for the HCLs. Major adverse cardiac event (MACE) and target vessel failure (TVF) were assessed at 3-year follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>Among 2432 patients included in the study, 210(8.6%) had HCLs with a procedural success rate of 91.0%. The patients with HCLs had a higher incidence of MACE (23.3% vs. 10.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) than those with non-HCLs. By propensity score matching, 172 patients with HCLs were 1:1 paired to those with non-HCLs, and their PCI vessels were exactly matched. The MACE and TVF were significantly higher in the patients with HCLs than those with non-HCLs (MACE: 21.5% vs. 13.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.036; TVF: 19.8% vs. 9.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.008). In the Cox regression analysis, HCL is independently associated with higher risks of MACE [HR: 1.72(1.01\u20132.94), <jats:italic>P<\/jats:italic>\u2009=\u20090.047], TVF [HR: 2.10(1.15\u20133.81), <jats:italic>P<\/jats:italic>\u2009=\u20090.015] and repeat revascularization [HR: 2.20(1.07\u20134.52), <jats:italic>P<\/jats:italic>\u2009=\u20090.032].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with HCLs undergoing PCI using CBs in combination with non-compliant balloons had higher risks of complications, procedural failure, and worse clinical outcomes at 3\u00a0years than those with non-HCLs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02622-9","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T21:04:54Z","timestamp":1650575094000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["3-Year outcomes in patients with heavily calcified lesions undergoing percutaneous coronary intervention using cutting balloons"],"prefix":"10.1186","volume":"22","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longhai","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"2622_CR1","doi-asserted-by":"publisher","first-page":"e009870","DOI":"10.1161\/CIRCINTERVENTIONS.120.009870","volume":"14","author":"M Shah","year":"2021","unstructured":"Shah M, Najam O, Bhindi R, De Silva K. 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All methods were performed following the Declaration of Helsinki. The patient informed consent was waived by the institutional ethics committee of Guizhou Provincial People\u2019s Hospital since the data were deidentified.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"187"}}