{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:47:03Z","timestamp":1793890023335,"version":"4.8.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>There are many studies on high-sensitivity C-reactive protein (hs-CRP) association with cardiovascular disease (CVD); however, just a few studies investigated whether the low-density lipoprotein cholesterol (LDL-C) could participate in hs-CRP prognostic strength. This study aimed to determine the alliance of hs-CRP and LDL-C in different concentrations in occurrence cardiovascular events in the Isfahan Cohort Study (ICS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>3277 participants aged 35 and above were included in the current analysis. We evaluated the association of elevated hs-CRP levels (\u2265\u20093\u00a0mg\/dL) and CVD events including myocardial infarction, ischemic heart disease, stroke, CVD, CVD mortality, and all-cause mortality in those with LDL-C\u2009\u2265\u2009or\u2009&lt;\u2009130\u00a0mg\/dL Cox frailty models was used to determine possible interactions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In both crude and fully adjusted models, there was no significant interaction between LDL-C and hs-CRP levels with the incidence of MI, stroke, CVD mortality, and all-cause death. Neither elevated LDL-C alone nor elevated CRP alone were associated with the risk of all cardiovascular events and all-cause death. However, participants with elevated concentrations of both hs-CRP and LDL-C had a greater risk of ischemic heart disease (IHD) (hazards ratio (HR) 1.44; 95% CI 1.03\u20132.02) and CVD (HR 1.36; 95% CI 1.01\u20131.83) than those with low LDL-C and hs-CRP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These results indicate that despite a null association between elevated levels of CRP or LDL-C alone and CVD events, concurrent rise in LDL-C and hs-CRP levels is associated with higher risk of IHD and CVD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02663-0","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T10:03:13Z","timestamp":1653472993000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High-sensitivity C-reactive protein and low-density lipoprotein cholesterol association with incident of cardiovascular events: Isfahan cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Amirhossein","family":"Nafari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin","family":"Mohammadifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Haghighatdoost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Nasirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid","family":"Najafian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Roohafza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizal","family":"Sarrafzadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"issue":"10053","key":"2663_CR1","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","volume":"388","author":"H Wang","year":"2016","unstructured":"Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459\u2013544.","journal-title":"Lancet"},{"key":"2663_CR2","unstructured":"WHO. Cardiovascular diseases (CVDs) 2021 [updated 11 June 2021. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"2663_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09637486.2021.1895725","volume":"72","author":"M Sadeghi","year":"2021","unstructured":"Sadeghi M, Simani M, Mohammadifard N, Talaei M, Roohafza H, Hassannejad R, et al. Longitudinal association of dietary fat intake with cardiovascular events in a prospective cohort study in Eastern Mediterranean region. Int J Food Sci Nutr. 2021;72:1\u201310.","journal-title":"Int J Food Sci Nutr"},{"issue":"1","key":"2663_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","volume":"70","author":"GA Roth","year":"2017","unstructured":"Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1\u201325.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2663_CR5","first-page":"24","volume":"22","author":"M Rahmani","year":"2019","unstructured":"Rahmani M, Jeddi S, Ghanbari M, Momenan AA, Azizi F. Ghasemi AJAoIm. Reference values for serum lipid profiles in Iranian adults: Tehran lipid and glucose study. 2019;22(1):24\u201331.","journal-title":"Reference values for serum lipid profiles in Iranian adults: Tehran lipid and glucose study"},{"issue":"9","key":"2663_CR6","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11883-014-0435-z","volume":"16","author":"E Golia","year":"2014","unstructured":"Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Pariggiano I, et al. Inflammation and cardiovascular disease: from pathogenesis to therapeutic target. Curr Atheroscler Rep. 2014;16(9):435.","journal-title":"Curr Atheroscler Rep"},{"issue":"4","key":"2663_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1365-2796.2008.02015.x","volume":"264","author":"J Casas","year":"2008","unstructured":"Casas J, Shah T, Hingorani A, Danesh J, Pepys M. C-reactive protein and coronary heart disease: a critical review. J Intern Med. 2008;264(4):295\u2013314.","journal-title":"J Intern Med"},{"issue":"5","key":"2663_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.jacc.2013.05.016","volume":"62","author":"O Yousuf","year":"2013","unstructured":"Yousuf O, Mohanty BD, Martin SS, Joshi PH, Blaha MJ, Nasir K, et al. High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link? J Am Coll Cardiol. 2013;62(5):397\u2013408.","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2663_CR9","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.repce.2012.09.006","volume":"31","author":"D Silva","year":"2012","unstructured":"Silva D, de Lacerda AP. High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease. Revista Portuguesa de Cardiologia (English Edition). 2012;31(11):733\u201345.","journal-title":"Revista Portuguesa de Cardiologia (English Edition)"},{"key":"2663_CR10","first-page":"83","volume":"27","author":"M Pepys","year":"1985","unstructured":"Pepys M, Rowe I, Baltz M. C-reactive protein: binding to lipids and lipoproteins. Int Rev Exp Pathol. 1985;27:83\u2013111.","journal-title":"Int Rev Exp Pathol"},{"issue":"1","key":"2663_CR11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1084\/jem.156.1.230","volume":"156","author":"F De Beer","year":"1982","unstructured":"De Beer F, Soutar AK, Baltz ML, Trayner I, Feinstein A, Pepys M. Low density lipoprotein and very low density lipoprotein are selectively bound by aggregated C-reactive protein. J Exp Med. 1982;156(1):230\u201342.","journal-title":"J Exp Med"},{"issue":"9","key":"2663_CR12","first-page":"409","volume":"105","author":"MB Clearfield","year":"2005","unstructured":"Clearfield MB. C-reactive protein: a new risk assessment tool for cardiovascular disease. J Am Osteopath Assoc. 2005;105(9):409\u201316.","journal-title":"J Am Osteopath Assoc"},{"issue":"9","key":"2663_CR13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/jhh.2010.99","volume":"25","author":"N Sarrafzadegan","year":"2011","unstructured":"Sarrafzadegan N, Talaei M, Sadeghi M, Kelishadi R, Oveisgharan S, Mohammadifard N, et al. The Isfahan cohort study: rationale, methods and main findings. J Hum Hypertens. 2011;25(9):545\u201353.","journal-title":"J Hum Hypertens"},{"issue":"10","key":"2663_CR14","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1017\/S1368980009004856","volume":"12","author":"N Sarrafzadegan","year":"2009","unstructured":"Sarrafzadegan N, Azadbakht L, Mohammadifard N, Esmaillzadeh A, Safavi M, Sajadi F, et al. Do lifestyle interventions affect dietary diversity score in the general population? Public Health Nutr. 2009;12(10):1924\u201330.","journal-title":"Public Health Nutr"},{"key":"2663_CR15","unstructured":"Sarrafzadegan N, Kelishadi R, Sadri G, Malekafzali H, Pourmoghaddas M, Heidari K, et al. Outcomes of a comprehensive healthy lifestyle program on cardiometabolic risk factors in a developing country: the Isfahan Healthy Heart Program. Archives of Iranian medicine. 2013;16(1)."},{"issue":"19","key":"2663_CR16","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560\u201371.","journal-title":"JAMA"},{"key":"2663_CR17","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1161\/01.HYP.7.4.641","volume":"7","author":"WGo Risk","year":"1985","unstructured":"Risk WGo, Pressure HB. An epidemiological approach to describing risk associated with blood pressure levels. Hypertension. 1985;7:641\u201351.","journal-title":"Hypertension"},{"key":"2663_CR18","unstructured":"Organization WH. Obesity: preventing and managing the global epidemic. 2000."},{"issue":"6","key":"2663_CR19","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1093\/clinchem\/28.6.1379","volume":"28","author":"G Warnick","year":"1982","unstructured":"Warnick G, Benderson J, Albers J. Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem. 1982;28(6):1379\u201388.","journal-title":"Clin Chem"},{"issue":"6","key":"2663_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499\u2013502.","journal-title":"Clin Chem"},{"issue":"5","key":"2663_CR21","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0022-2275(20)39173-2","volume":"35","author":"EJ Schaefer","year":"1994","unstructured":"Schaefer EJ, Lamon-Fava S, Cohn SD, Schaefer MM, Ordovas J, Castelli W, et al. Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study. J Lipid Res. 1994;35(5):779\u201392.","journal-title":"J Lipid Res"},{"key":"2663_CR22","first-page":"35","volume-title":"WHO draft protocol and manual of operations population survey for cardiovascular disease risk factors in the Eastern Mediterranean Region","author":"WH Organization","year":"1995","unstructured":"Organization WH. WHO draft protocol and manual of operations population survey for cardiovascular disease risk factors in the Eastern Mediterranean Region. Alexandria: World Health Organization; 1995. p. 35."},{"key":"2663_CR23","doi-asserted-by":"crossref","unstructured":"Detection NCEPEPo, Adults ToHBCi. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): The Program; 2002.","DOI":"10.1001\/jama.285.19.2486"},{"issue":"3","key":"2663_CR24","first-page":"132","volume":"12","author":"D Kazemi-Saleh","year":"2016","unstructured":"Kazemi-Saleh D, Koosha P, Sadeghi M, Sarrafzadegan N, Karbasi-Afshar R, Boshtam M, et al. Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: the Isfahan Cohort study. ARYA Atherosclerosis. 2016;12(3):132.","journal-title":"ARYA Atherosclerosis"},{"issue":"3","key":"2663_CR25","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","volume":"107","author":"TA Pearson","year":"2003","unstructured":"Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107(3):499.","journal-title":"Circulation"},{"issue":"20","key":"2663_CR26","first-page":"2543","volume":"108","author":"RV Luepker","year":"2003","unstructured":"Luepker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D, et al. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart. Lung, and Blood Institute. 2003;108(20):2543\u20139.","journal-title":"Lung, and Blood Institute"},{"key":"2663_CR27","doi-asserted-by":"crossref","unstructured":"Members C, Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, et al. ACC\/AHA guideline update for the management of patients with unstable angina and non\u2013ST-segment elevation myocardial infarction\u20142002: summary article: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). 2002;106(14):1893\u2013900.","DOI":"10.1161\/01.CIR.0000037106.76139.53"},{"issue":"20","key":"2663_CR28","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1056\/NEJMoa021993","volume":"347","author":"PM Ridker","year":"2002","unstructured":"Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347(20):1557\u201365.","journal-title":"N Engl J Med"},{"issue":"5","key":"2663_CR29","doi-asserted-by":"publisher","first-page":"432","DOI":"10.5551\/jat.45989","volume":"26","author":"K Kitagawa","year":"2019","unstructured":"Kitagawa K, Hosomi N, Nagai Y, Kagimura T, Ohtsuki T, Maruyama H, et al. Cumulative effects of LDL cholesterol and CRP levels on recurrent stroke and TIA. J Atheroscler Thromb. 2019;26(5):432\u201341.","journal-title":"J Atheroscler Thromb"},{"issue":"10","key":"2663_CR30","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1111\/bph.12616","volume":"171","author":"F Bian","year":"2014","unstructured":"Bian F, Yang X, Zhou F, Wu PH, Xing S, Xu G, et al. C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells. Br J Pharmacol. 2014;171(10):2671\u201384.","journal-title":"Br J Pharmacol"},{"issue":"2","key":"2663_CR31","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1373\/clinchem.2015.243923","volume":"62","author":"N Stancel","year":"2016","unstructured":"Stancel N, Chen C-C, Ke L-Y, Chu C-S, Lu J, Sawamura T, et al. Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem. 2016;62(2):320\u20137.","journal-title":"Clin Chem"},{"issue":"11","key":"2663_CR32","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1212\/WNL.0000000000001367","volume":"84","author":"HJ Kim","year":"2015","unstructured":"Kim HJ, Paul F, Lana-Peixoto MA, Tenembaum S, Asgari N, Palace J, et al. MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Neurology. 2015;84(11):1165\u201373.","journal-title":"Neurology"},{"issue":"1","key":"2663_CR33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.2967\/jnumed.110.080838","volume":"52","author":"HJ Yoo","year":"2011","unstructured":"Yoo HJ, Kim S, Park MS, Yang SJ, Kim TN, Seo JA, et al. Vascular inflammation stratified by C-reactive protein and low-density lipoprotein cholesterol levels: analysis with 18F-FDG PET. J Nucl Med. 2011;52(1):10\u20137.","journal-title":"J Nucl Med"},{"issue":"1","key":"2663_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5334\/gh.367","volume":"15","author":"P Koosha","year":"2020","unstructured":"Koosha P, Roohafza H, Sarrafzadegan N, Vakhshoori M, Talaei M, Sheikhbahaei E, et al. High sensitivity C-reactive protein predictive value for cardiovascular disease: a nested case control from Isfahan cohort study (ICS). Glob Heart. 2020;15(1):3.","journal-title":"Glob Heart"},{"issue":"12","key":"2663_CR35","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJM200003233421202","volume":"342","author":"PM Ridker","year":"2000","unstructured":"Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342(12):836\u201343.","journal-title":"N Engl J Med"},{"issue":"40","key":"2663_CR36","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1093\/eurheartj\/ehy533","volume":"39","author":"PE Penson","year":"2018","unstructured":"Penson PE, Long DL, Howard G, Toth PP, Muntner P, Howard VJ, et al. Associations between very low concentrations of low density lipoprotein cholesterol, high sensitivity C-reactive protein, and health outcomes in the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study. Eur Heart J. 2018;39(40):3641\u201353.","journal-title":"Eur Heart J"},{"issue":"3","key":"2663_CR37","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/dom.13136","volume":"20","author":"YC Hwang","year":"2018","unstructured":"Hwang YC, Morrow DA, Cannon CP, Liu Y, Bergenstal R, Heller S, et al. High-sensitivity C-reactive protein, low-density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial. Diabetes Obes Metab. 2018;20(3):654\u20139.","journal-title":"Diabetes Obes Metab"},{"issue":"31","key":"2663_CR38","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1093\/eurheartj\/ehaa160","volume":"41","author":"PM Ridker","year":"2020","unstructured":"Ridker PM, MacFadyen JG, Glynn RJ, Bradwin G, Hasan AA, Rifai N. Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk in contemporary practice: secondary analyses from the Cardiovascular Inflammation Reduction Trial. Eur Heart J. 2020;41(31):2952\u201361.","journal-title":"Eur Heart J"},{"issue":"1","key":"2663_CR39","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/aje\/kwv144","volume":"183","author":"G-M Lin","year":"2016","unstructured":"Lin G-M, Liu K, Colangelo LA, Lakoski SG, Tracy RP, Greenland P. Low-density lipoprotein cholesterol concentrations and association of high-sensitivity C-reactive protein concentrations with incident coronary heart disease in the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2016;183(1):46\u201352.","journal-title":"Am J Epidemiol"},{"issue":"19","key":"2663_CR40","first-page":"2145","volume":"124","author":"L Mosca","year":"2011","unstructured":"Mosca L, Barrett-Connor E, Kass Wenger NJC. Sex\/gender differences in cardiovascular disease prevention: what a difference a decade makes. 2011;124(19):2145\u201354.","journal-title":"Sex\/gender differences in cardiovascular disease prevention: what a difference a decade makes"},{"key":"2663_CR41","doi-asserted-by":"crossref","unstructured":"Wang T, Zhao Z, Yu X, Zeng T, Xu M, Xu Y, et al. Age-specific modifiable risk factor profiles for cardiovascular disease and all-cause mortality: a nationwide, population-based, prospective cohort study. 2021;17:100277.","DOI":"10.1016\/j.lanwpc.2021.100277"},{"issue":"12","key":"2663_CR42","doi-asserted-by":"publisher","first-page":"11990","DOI":"10.18632\/aging.103365","volume":"12","author":"J Mo","year":"2020","unstructured":"Mo J, Chen Z, Xu J, Wang A, Meng X, Zhao X, et al. The impact of the cumulative burden of LDL-c and hs-CRP on cardiovascular risk: a prospective, population-based study. Aging (Albany NY). 2020;12(12):11990.","journal-title":"Aging (Albany NY)"},{"key":"2663_CR43","doi-asserted-by":"crossref","unstructured":"Fang M, Qian Q, Zhao Z, Zhu L, Su J, Li X. High-sensitivity C-reactive protein combined with low-density lipoprotein cholesterol as the targets of statin therapy in patients with acute coronary syndrome. International heart journal. 2018:17\u2013101.","DOI":"10.1536\/ihj.17-101"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-022-02663-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-022-02663-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-022-02663-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T10:03:37Z","timestamp":1653473017000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-022-02663-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2663"],"URL":"https:\/\/doi.org\/10.1186\/s12872-022-02663-0","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"19 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics committee of the Research Council of Isfahan Cardiovascular Research Center (ICRC), a WHO collaborating center in Isfahan, Iran was approved the study. The written informed consent was obtained from all subjects and\/or their legal guardian(s).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All methods were carried out in accordance with Declarations of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Accordance"}},{"value":"The authors report no relationships that could be construed as a competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of interests"}}],"article-number":"241"}}