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We investigated the effect of intra-coronary nitroglycerin on the relief of coronary artery stenosis in the candidates for percutaneous coronary intervention (PCI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included patients with angina pectoris or myocardial infarction who were candidates for PCI. In the coronary angiography, the culprit vessel involved was evaluated, and bolus nitroglycerin at a dose of 25\u2013200\u00a0mcg was injected into the affected coronary artery. A significant change in the percentage of coronary artery stenosis was considered a positive response, and these patients were then compared with patients who did not have a substantial change in the percentage of stenosis at the same time. Univariate analysis and then multivariate logistic regression analysis was performed to determine the predictors of response to intracoronary nitroglycerin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 360 patients, 27 (7.5%) responded to nitroglycerine, and 333 (92.5%) were non-responsive. The mean age of patients was 60.2\u2009\u00b1\u200911.6\u00a0years, ranging from 23 to 93\u00a0years, and 265 (73.6%) were men. The study groups were not significantly different in the baseline demographic characteristics. The presence of multivessel disease (Odds ratio (OR)\u2009=\u200916.26, 95% confidence interval (CI):2.07\u2013127.6; <jats:italic>P<\/jats:italic>\u2009=\u20090.008) and stenosis in the left circumflex artery (OR\u2009=\u20093.62, 95% CI: 1.03\u201312.70; <jats:italic>P<\/jats:italic>\u2009=\u20090.044) were the independent predictors for nonresponse to nitroglycerine, leading to PCI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In some cases, especially those without multivessel diseases, intracoronary nitroglycerine administration can efficiently relieve coronary stenosis and prevent unnecessary PCI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02823-2","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T12:02:24Z","timestamp":1663502544000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intracoronary injection of nitroglycerine can prevent unnecessary percutaneous coronary intervention"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-2997","authenticated-orcid":false,"given":"Amirhossein","family":"Nasiri-Partovi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-7788","authenticated-orcid":false,"given":"Akbar","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-0825","authenticated-orcid":false,"given":"Reza","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"issue":"12","key":"2823_CR1","first-page":"721","volume":"102","author":"JR McConaghy","year":"2020","unstructured":"McConaghy JR, Sharma M, Patel H. 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The study protocol was designed in accordance with the Declaration of Helsinki and its updates. Additionally, all patients signed a written informed consent at admission and consented that their clinical data could be used anonymously for research purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"416"}}