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The association between NT-proBNP and clinical outcomes in acute ischemic patients was assessed by logistic regression and adjusted for confounding factors. Also, subgroup analyses were conducted based on treatment decisions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>NT-proBNP was positively correlated with CTP ischemic volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), infarct core volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and ischemic penumbra volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Univariate analysis showed that the influence of NT-proBNP and functional outcomes were statistically significant in model 1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). This phenomenon was persistent after adjusted for age, sex, and body mass index in model 2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.011), adjusted for SBP, current smoking, family history of stroke, hypertension, and diabetes mellitus in model 3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and adjusted for TnI, D-dimer, PLT, Cr, TC, TG, HDL-C, treatment decisions, and NIHSS score in model 4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.027). A high NT-proBNP was associated with a high 90-days mRS score among the total population, IV rt-PA, and standardized treatment groups, but not in IV rt-PA\u2009+\u2009EVT, EVT, and EVT\/IV rt-PA\u2009+\u2009EVT groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Elevated NT-proBNP levels reveal large CTP infarct core volume and poor 90-day functional outcome in AIS. NT-pro BNP is an independent risk factor for functional outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02861-w","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T07:02:59Z","timestamp":1664521379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaozhu","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"issue":"2","key":"2861_CR1","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1055\/s-0038-1649503","volume":"38","author":"M Katan","year":"2018","unstructured":"Katan M, Luft A. 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