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The collected data included clinical data, hematological indexes, and brachial-ankle pulse wave velocity (Ba-PWV). Atherosclerosis was defined as Ba-PWV\u2009\u2265\u20091400\u00a0cm\/s. The relationship between the NHR and atherosclerosis was explored via univariate regression analysis, multivariate regression analysis, smoothing function analysis, and analysis of a threshold saturation effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 1978 participants, the mean age was 54\u00a0years, 1189 participants (60.11%) were male, and 1103 (55.76%) had a history of atherosclerosis. Univariate analysis showed a positive association between the NHR and atherosclerosis [odds ratio (OR)\u2009=\u20091.19, 95% confidence interval (CI): 1.11\u20131.27, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01], and this positive association remained significant on multivariate analyses with adjustments for confounding factors (OR\u2009=\u20091.14, 95% CI: 1.06\u20131.24, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Generalized additive model results revealed a non-linear relationship with a saturation effect between the NHR and atherosclerosis, with a threshold at 3.32. At values\u2009\u2264\u20093.32, the NHR was positively associated with atherosclerosis, but the association was not statistically significant for values\u2009&gt;\u20093.32.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A nonlinear relationship with a certain saturation effect was observed between the NHR and atherosclerosis in a health examination population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02869-2","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T13:04:01Z","timestamp":1664197441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nonlinear relationship with saturation effect observed between neutrophil to high-density lipoprotein cholesterol ratio and atherosclerosis in a health examination population: a cross\u2010sectional study"],"prefix":"10.1186","volume":"22","author":[{"given":"Yaqing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"2869_CR1","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/HCO.0000000000000179","volume":"30","author":"I Ikonomidis","year":"2015","unstructured":"Ikonomidis I, Makavos G, Lekakis J. 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All participants informed consent and volunteered to participate in the study. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"424"}}