{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:20:33Z","timestamp":1791606033344,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) is associated with higher morbidity and mortality rates in patients with chronic kidney disease (CKD). Studies have shown that vascular calcification is a major predictor of CVD. Vascular calcification in the CKD population is associated with various risk factors, and changes in bone and mineral metabolism have been linked to an increased risk of atherosclerosis. Therefore, we aimed to investigate the correlation between vascular calcification and bone metabolism, which is necessary to improve the survival and prognosis of patients with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 146 patients with CKD who received coronary artery calcification (CAC) scores at our hospital from May 2017 to November 2018. Spearman rank correlation analysis, Mann\u2013Whitney U test, and Kaplan\u2013Meier method were used to analyze laboratory data and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the 146 patients, chronic glomerulonephritis accounted for the most common cause of CKD, at approximately 39.0%. Spearman rank correlation analysis on the factors influencing vascular calcification in patients with CKD showed that CAC score was significantly and positively correlated with C-reactive protein, N-terminal\/midregion osteocalcin (N-MID), N-terminal peptide of type 1 procollagen (P1NP), \u03b2-cross-linked C-telopeptide of type 1 collagen (\u03b2-CTx), and parathyroid hormone (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0423,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0432,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0235,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0061,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001, respectively). Serum calcium levels were positively correlated with N-MID, P1NP, \u03b2-CTx, and iPTH (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.19,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.24,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.21,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.21, respectively), and serum phosphorus levels were positively correlated with N-MID, P1NP, \u03b2-CTx, and iPTH (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.50,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.37,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.50,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.55, respectively). However, no difference was found in CVC scores among patients with CKD in different stages and receiving different treatments. In the Kaplan\u2013Meier analysis of all-cause hospitalization and mortality rates, patients with CAC\u2009&gt;\u2009400 had a higher risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that the primary cause of CKD is glomerulonephritis, and the CAC score is positively correlated with inflammatory and bone metabolism markers, with a higher risk of all-cause mortality and cardiovascular hospitalization when the CAC score is greater than 400.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-022-02879-0","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T08:03:02Z","timestamp":1667030582000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Coronary artery calcification in patients with advanced chronic kidney disease"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiadan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"2879_CR1","unstructured":"Global regional. and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. 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The study was carried out in accordance with the Declaration of Helsinki and approved by the Medical ethics committee of zhejiang provincial people\u2019 s hospital Medical ethics committee of zhejiang provincial people\u2019 s hospital(ApprovalNo. (Zhejiang Medical Ethics Review 2022 OtherNo. (162))).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors had no known competing financial interest or personal relationship that could have appeared to influence the work reported in this paper. No tables or Figures are taken from other study.Funding Sources.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"453"}}