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Some studies have also indicated that a low serum bicarbonate concentration is inversely related to the mortality risk of patients with cardiogenic shock. However, the value of bicarbonate and the L\/A ratio for predicting the mortality risk of patients with acute myocardial infarction (AMI) is still unclear. We therefore conducted a retrospective study to research this problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The subjects of this study were patients with AMI, and the data source was the Medical Information Mart for Intensive Care III database. The primary endpoint was 30-day all-cause mortality after admission. The Receiver operating characteristic (ROC) curve was used to compare the predictive value of L\/A ratio, lactate and albumin for end-point events. The effects of different L\/A ratio levels and different bicarbonate concentrations on 7-day and 30-day all-cause mortality were compared using Kaplan\u2013Meier (K-M) curves. Hazard ratios for different L\/A ratio and different bicarbonate concentrations were investigated using COX proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Area Under Curve (AUC) of L\/A ratio, lactate, and albumin were 0.736, 0.718, and 0.620, respectively. (1) L\/A ratio: The patients were divided into three groups according to their L\/A ratio: tertile T1 (L\/A ratio\u2009\u2264\u20090.47), tertile T2 (L\/A ratio\u2009\u2264\u20090.97), and tertile T3 (L\/A ratio\u2009&gt;\u20090.97). The T2 and T3 groups had higher 30-day all-cause mortality risks than the T1 group. The restricted cubic spline (RCS) model indicated that there was a nonlinear relationship between L\/A ratio and 30-day mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). (2) Bicarbonate concentration: The patients were also divided into three groups based on their bicarbonate concentration: G1 (22\u201327\u00a0mmol\/L), G2 (&lt;\u200922\u00a0mmol\/L), and G3 (&gt;\u200927\u00a0mmol\/L). The G2 and G3 groups had higher 30-day all-cause mortality risks than the G1 group. The RCS model indicated that there was a nonlinear relationship between bicarbonate concentration and 30-day mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The RCS model indicated that there was a nonlinear relationship between hemoglobin level and 30-day all-cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>L\/A ratio and bicarbonate concentration and hemoglobin level have predictive value for predicting 30-day mortality in patients with acute myocardial infarction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-022-02902-4","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T05:03:03Z","timestamp":1668747783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association of lactate to albumin ratio and bicarbonate with short-term mortality risk in patients with acute myocardial infarction"],"prefix":"10.1186","volume":"22","author":[{"given":"Jia-Liang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Rui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"2902_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijcard.2016.02.022","volume":"209","author":"WH Yin","year":"2016","unstructured":"Yin WH, Lu TH, Chen KC, Cheng CF, Lee JC, Liang FW, Huang YT, Yang LT. 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Our study was consistent with the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) statement. All methods were also carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"490"}}