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We aimed to evaluate the characteristics of cardiac function on cardiopulmonary exercise test (CPET) in IHD with different coronary stenoses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Totally 614 patients with IHD were divided into non-obstructive coronary artery disease (NOCAD) (stenosis\u2009&lt;\u200950%), obstructive coronary artery disease (OCAD) (stenosis 50-90%) and severe OCAD ( stenosis\u2009&gt;\u200990%) according to the coronary angiography. And 101 healthy volunteers as controls. All participants performed CPET to assess cardiac function by oxygen uptake (VO<jats:sub>2<\/jats:sub>), estimated cardiac output (CO), and heart rate (HR).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Generally, the values of VO<jats:sub>2<\/jats:sub>, CO, and HR in IHD were significantly lower than in healthy volunteers. Among 289 NOCAD, 132 OCAD, and 193 severe OCAD, significantly decreased values of VO<jats:sub>2<\/jats:sub>, CO, HR were observed (VO<jats:sub>2<\/jats:sub> peak: 16.01\u2009\u00b1\u20094.11 vs. 15.66\u2009\u00b1\u20094.14 vs. 13.33\u2009\u00b1\u20093.4 mL\/min\/kg; CO: 6.96\u2009\u00b1\u20092.34 vs. 6.87\u2009\u00b1\u20092.37 vs. 6.05\u2009\u00b1\u20091.79\u00a0L\/min; HR: 126.44\u2009\u00b1\u200920.53 vs. 115.15\u2009\u00b1\u200918.78 vs. 109.07\u2009\u00b1\u200916.23\u00a0bpm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). NOCAD had significantly lower VO<jats:sub>2<\/jats:sub> at anaerobic threshold (-1.35, 95%CI -2.16 - -0.54) and VO<jats:sub>2<\/jats:sub> peak (-2.05, 95%CI -3.18 - -0.93) compared with healthy volunteers after adjustment. All IHD patients were associated with low stroke volume and inefficient gas exchange (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>IHD with increasing atherosclerotic burdens were associated with impaired cardiac output and chronotropic response on CPET. NOCAD should be given more early prevention and rigorous follow-up.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02935-9","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T18:02:53Z","timestamp":1668448973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Coronary stenosis is a risk marker for impaired cardiac function on cardiopulmonary exercise test"],"prefix":"10.1186","volume":"22","author":[{"given":"Siyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boda","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"issue":"2","key":"2935_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1161\/CIRCRESAHA.116.308952","volume":"119","author":"A Ahmadi","year":"2016","unstructured":"Ahmadi A, Stone GW, Leipsic J, Shaw LJ, Villines TC, Kern MJ, Hecht H, Erlinge D, Ben-Yehuda O, Maehara A, et al. 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