{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:42:17Z","timestamp":1789792937945,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Cryptococcus neoformans<\/jats:italic> is an invasive fungal infection commonly affecting immunocompromised patients as pneumonia or meningitis. More rarely, case reports describe <jats:italic>Cryptococcus neoformans<\/jats:italic> endocarditis, though nearly exclusively among patients with active immunosuppression, implanted cardiac devices or prosthetic valves.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the case of a patient with underlying substance abuse disorder and systolic heart failure presenting with fever, altered mental status, and shower emboli subsequently found to have native tricuspid valve vegetations and blood cultures positive for <jats:italic>cryptococcus neoformans<\/jats:italic> in the absence of immunosuppression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Historically, <jats:italic>Cryptococcus neoformans<\/jats:italic> fungemia manifests clinically as pneumonia or meningitis among the immunosuppressed. There have been rare reports of endocarditis in this population and even fewer reports of native valve endocarditis exist. The present case along with mortality reported in prior literature, suggest suspicion must be maintained in the absence of immunosuppression, even in patients with native valves.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-022-02997-9","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T15:03:12Z","timestamp":1671807792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cryptococcus neoformans endocarditis in an immunocompetentpatient a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Colin N.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-5307","authenticated-orcid":false,"given":"Dylan J.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"2997_CR1","doi-asserted-by":"crossref","unstructured":"Coelho C, Bocca AL, Casadevall A. Chapter one\u2014the tools for virulence of Cryptococcus neoformans. In: Sariaslani S, Gadd GM, editors. Advances in applied microbiology 2014;87:1\u201341.","DOI":"10.1016\/B978-0-12-800261-2.00001-3"},{"issue":"6","key":"2997_CR2","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/clinids\/13.6.1163","volume":"1","author":"SM Levitz","year":"1991","unstructured":"Levitz SM. The Ecology of Cryptococcus neoformans and the epidemiology of Cryptococcosis. Rev Infect Dis. 1991;1(6):1163\u20139. 13(.","journal-title":"Rev Infect Dis"},{"issue":"1","key":"2997_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/clinids\/21.1.28","volume":"21","author":"B Speed","year":"1995","unstructured":"Speed B, Dunt D. Clinical and host differences between infections with the two varieties of Cryptococcus neoformans. 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