{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:38:06Z","timestamp":1793637486824,"version":"4.5.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Addison\u2019s disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison\u2019s disease may accelerate progression of co-existed cardiovascular diseases. Addison\u2019s disease combined with cardiovascular disease is infrequent, only 10 cases in the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We reported a 51-year-old male patient with unstable angina pectoris and hypotension. Changes on coronary angiography within 2 years suggested rapid progression of coronary artery disease in a patient with low cardiovascular risk. An additional clue of skin hyperpigmentation, fatigue and further examination confirmed the diagnosis of Addison\u2019s disease caused by adrenal tuberculosis. After hormone replacement treatment, the frequency and severity of the angina pectoris were alleviated significantly, as were hypotension, hyperpigmentation and fatigue.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The combination of Addison\u2019s disease and coronary artery disease in one patient is rare. Addison\u2019s disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison\u2019s disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-023-03079-0","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T01:04:34Z","timestamp":1674954274000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Coronary artery disease in a patient with Addison\u2019s disease: a case report and literature review"],"prefix":"10.1186","volume":"23","author":[{"given":"Ruohan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-9073","authenticated-orcid":false,"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"issue":"36","key":"3079_CR1","first-page":"404","volume":"18","author":"A Thomas","year":"1856","unstructured":"Thomas A. On the constitutional and local effects of disease of the supra-renal capsules. Br Foreign Med-Chir Rev. 1856;18(36):404\u201313.","journal-title":"Br Foreign Med-Chir Rev"},{"issue":"2","key":"3079_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/joim.12162","volume":"275","author":"ES Husebye","year":"2014","unstructured":"Husebye ES, Allolio B, Arlt W, Badenhoop K, Bensing S, Betterle C, Falorni A, Gan EH, Hulting AL, Kasperlik-Zaluska A, et al. Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med. 2014;275(2):104\u201315.","journal-title":"J Intern Med"},{"issue":"12","key":"3079_CR3","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.7326\/0003-4819-127-12-199712150-00009","volume":"127","author":"RM Carey","year":"1997","unstructured":"Carey RM. The changing clinical spectrum of adrenal insufficiency. Ann Intern Med. 1997;127(12):1103\u20135.","journal-title":"Ann Intern Med"},{"issue":"100","key":"3079_CR4","first-page":"915","volume":"12","author":"L Wang","year":"2020","unstructured":"Wang L, Lu L, Lu Z, Chen S, Zhu H, Pan H, Dduan L, Yang H, Wang L, Yuan T, et al. Etiology and clinical features of primary adrenal insufficiency. Natl Med J China. 2020;12(100):915\u201321.","journal-title":"Natl Med J China"},{"key":"3079_CR5","unstructured":"The writing Committee of the Report on Cardiovascular Health and Disease in China: Report on Cardiovascular health and diseases burden in china: an updated summary of 2020. Chin Circ J 2021, 36(06):521\u2013545."},{"issue":"5","key":"3079_CR6","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1210\/clinem\/dgab063","volume":"106","author":"K Ngaosuwan","year":"2021","unstructured":"Ngaosuwan K, Johnston D, Godsland I, Cox J, Majeed A, Quint J, Oliver N, Robinson S. Cardiovascular disease in patients with primary and secondary adrenal insufficiency and the role of comorbidities. J Clin Endocrinol Metab. 2021;106(5):1284\u201393.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3079_CR7","first-page":"4","volume":"6","author":"X Zhou","year":"2012","unstructured":"Zhou X. Current status of diagnosis and treatment of adrenal tuberculosis with Addison\u2019s disease. Chin J Endourol (Electron Ed). 2012;6(3):4.","journal-title":"Chin J Endourol (Electron Ed)"},{"issue":"4","key":"3079_CR8","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jacc.2019.05.049","volume":"74","author":"N Ding","year":"2019","unstructured":"Ding N, Sang Y, Chen J, Ballew SH, Kalbaugh CA, Salameh MJ, Blaha MJ, Allison M, Heiss G, Selvin E, et al. Cigarette smoking, smoking cessation, and long-term risk of 3 major atherosclerotic diseases. J Am Coll Cardiol. 2019;74(4):498\u2013507.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"3079_CR9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s12020-020-02458-3","volume":"70","author":"D Esposito","year":"2020","unstructured":"Esposito D, Bobbio E, Di Fraia R, Mone P, Accardo G, De Bellis A, Iorio S, Esposito K, Marfella R, Johannsson G, et al. Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia. Endocrine. 2020;70(2):412\u201320.","journal-title":"Endocrine"},{"issue":"8","key":"3079_CR10","doi-asserted-by":"publisher","first-page":"746","DOI":"10.4158\/EP-2018-0114","volume":"24","author":"T Yamamoto","year":"2018","unstructured":"Yamamoto T. Latent Adrenal insufficiency: concept, clues to detection, and diagnosis. Endocr Pract: Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2018;24(8):746\u201355.","journal-title":"Endocr Pract: Off J Am Coll Endocrinol Am Assoc Clin Endocrinol"},{"issue":"2","key":"3079_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3109\/10253890.2012.715221","volume":"16","author":"G Mastorakos","year":"2013","unstructured":"Mastorakos G, Paltoglou G, Greene M, Ilias I, Papamichalopoulos A, Dimopoulos S, Pouliou E, Fatouros IG, Nanas S. Inappropriately normal plasma ACTH and cortisol concentrations in the face of increased circulating interleukin-6 concentration in exercise in patients with sarcoidosis. Stress (Amsterdam, Netherlands). 2013;16(2):202\u201310.","journal-title":"Stress (Amsterdam, Netherlands)"},{"issue":"3","key":"3079_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1080\/07853890802508934","volume":"41","author":"J Nijm","year":"2009","unstructured":"Nijm J, Jonasson L. Inflammation and cortisol response in coronary artery disease. Ann Med. 2009;41(3):224\u201333.","journal-title":"Ann Med"},{"issue":"12","key":"3079_CR13","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1055\/s-0033-1351259","volume":"45","author":"I Ross","year":"2013","unstructured":"Ross I, Bergthorsdottir R, Levitt N, Schatz D, Johannsson G, Marais A. Increased cardiovascular risk in South African patients with Addison\u2019s disease. Horm Metab Res. 2013;45(12):905\u201310.","journal-title":"Horm Metab Res"},{"issue":"6","key":"3079_CR14","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.mehy.2012.09.001","volume":"79","author":"JF Evans","year":"2012","unstructured":"Evans JF, Ragolia L. Systemic and local ACTH produced during inflammatory states promotes osteochondrogenic mesenchymal cell differentiation contributing to the pathologic progression of calcified atherosclerosis. Med Hypotheses. 2012;79(6):823\u20136.","journal-title":"Med Hypotheses"},{"issue":"1","key":"3079_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.atherosclerosis.2008.08.023","volume":"204","author":"AO Pozzi","year":"2009","unstructured":"Pozzi AO, Bernardo E, Coronado MT, Punchard MA, Gonzalez P, Fantidis P. Acute arterial thrombosis in the absence of inflammation: the stress-related anti-inflammatory hormone ACTH participates in platelet-mediated thrombosis. Atherosclerosis. 2009;204(1):79\u201384.","journal-title":"Atherosclerosis"},{"issue":"9","key":"3079_CR16","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1507\/endocrj.EJ16-0242","volume":"63","author":"T Yanase","year":"2016","unstructured":"Yanase T, Tajima T, Katabami T, Iwasaki Y, Tanahashi Y, Sugawara A, Hasegawa T, Mune T, Oki Y, Nakagawa Y, et al. Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan endocrine society clinical practice guideline [Opinion]. Endocr J. 2016;63(9):765\u201384.","journal-title":"Endocr J"},{"issue":"2","key":"3079_CR17","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.3892\/etm.2020.8855","volume":"20","author":"M Maranduca","year":"2020","unstructured":"Maranduca M, Statescu C, Sascau R, Dima N, Hurjui L, Serban D, Serban I. Acute coronary syndrome with ST segment elevation in a patient with Addison disease: case report and brief review of physiopathological mechanisms: a case study. Exp Ther Med. 2020;20(2):1230\u20136.","journal-title":"Exp Ther Med"},{"issue":"2","key":"3079_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/BF01744458","volume":"7","author":"K Iga","year":"1992","unstructured":"Iga K, Hori K, Gen H. Deep negative T waves associated with reversible left ventricular dysfunction in acute adrenal crisis. Heart Vessel. 1992;7(2):107\u201311.","journal-title":"Heart Vessel"},{"issue":"11","key":"3079_CR19","first-page":"1539","volume":"97","author":"F Ozcan","year":"2005","unstructured":"Ozcan F, Ustun I, Berker D, Aydin Y, Delibasi T, Guler S. Inverted T waves in patient with Addisonian crisis. J Natl Med Assoc. 2005;97(11):1539\u201340.","journal-title":"J Natl Med Assoc"},{"issue":"4","key":"3079_CR20","first-page":"451","volume":"15","author":"M Akpa","year":"2006","unstructured":"Akpa M, Odia O. Addison\u2019s disease presenting as acute chest syndrome: case report and review of literature. Niger J Med: J Natl Assoc Resid Dr Niger. 2006;15(4):451\u20132.","journal-title":"Niger J Med: J Natl Assoc Resid Dr Niger"},{"issue":"2","key":"3079_CR21","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1016\/j.ijcard.2008.12.191","volume":"144","author":"S Punnam","year":"2010","unstructured":"Punnam S, Gourineni N, Gupta V. Takotsubo cardiomyopathy in a patient with Addison disease. Int J Cardiol. 2010;144(2):e34-36.","journal-title":"Int J Cardiol"},{"issue":"1","key":"3079_CR22","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1016\/j.ijcard.2008.06.007","volume":"138","author":"C Barcin","year":"2010","unstructured":"Barcin C, Kursaklioglu H, Kose S, Amasyali B, Isik E. Takotsubo cardiomyopathy in a patient with Addison disease: is apical ballooning always reversible? Int J Cardiol. 2010;138(1):e15-17.","journal-title":"Int J Cardiol"},{"issue":"12","key":"3079_CR23","doi-asserted-by":"publisher","first-page":"731","DOI":"10.4103\/0972-5229.171410","volume":"19","author":"G Singh","year":"2015","unstructured":"Singh G, Manickam A, Sethuraman M, Rathod R. Takotsubo cardiomyopathy in a patient with pituitary adenoma and secondary adrenal insufficiency. Indian J Crit Care Med: Peer-Rev Off Publ Indian Soc Crit Care Med. 2015;19(12):731\u20134.","journal-title":"Indian J Crit Care Med: Peer-Rev Off Publ Indian Soc Crit Care Med"},{"issue":"1","key":"3079_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13256-016-1074-5","volume":"10","author":"R Campean","year":"2016","unstructured":"Campean R, Hasun M, St\u00f6llberger C, Bucher J, Finsterer J, Schnack C, Weidinger F. Takotsubo-like syndrome triggered by fludrocortisone overdose for Addison\u2019s disease: a case report. J Med Case Rep. 2016;10(1):281.","journal-title":"J Med Case Rep"},{"issue":"15","key":"3079_CR25","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.2169\/internalmedicine.4337-19","volume":"59","author":"Y Otsuka","year":"2020","unstructured":"Otsuka Y, Harada K, Yasuda M, Nakano Y, Hasegawa K, Otsuka F. Coronary spastic angina induced by adrenal insufficiency. Intern Med. 2020;59(15):1873\u20137.","journal-title":"Intern Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03079-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-023-03079-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03079-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T01:07:42Z","timestamp":1674954462000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-023-03079-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3079"],"URL":"https:\/\/doi.org\/10.1186\/s12872-023-03079-0","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"14 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of their clinical details and clinical images was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author\u2019s decalared that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}