{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:13:21Z","timestamp":1789834401675,"version":"4.0.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Intimal sarcomas are an extremely rare type of primary cardiac malignancy. They most commonly present with symptoms of cardiac dysfunction. We present a case of intimal sarcoma identified without any cardiac signs or symptoms. Cardiac sarcomas historically carry a very poor prognosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Presentation<\/jats:title>\n                <jats:p>A 57-year-old man presented with a sudden onset of left limb weakness and disorientation. MRI brain identified an acute ischaemic stroke in the right anterior temporal lobe. Four months later, he presented again\u00a0with transient left arm weakness. The patient had a normal cardiovascular examination and ECG. All other initial investigations for cryptogenic stroke were non-contributory. The patient did not initially get an echocardiogram. When this investigation was performed, after his second presentation, a large pedunculated mass was present in his left atrium. This was resected and identified histologically as a primary intimal sarcoma of his left atrium. The patient was treated with post-operative radiotherapy but declined chemotherapy. He recovered well post-operatively but subsequently passed away 14\u00a0months after diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>It is possible for primary cardiac malignancies to present with only symptoms of systemic emboli. For this reason, echocardiography is a crucial investigation in cases of cryptogenic stroke. Some stroke guidelines do not definitively support routine echocardiography. Primary intimal cardiac sarcoma is a very rare condition with a poor prognosis. The literature is limited to case reports and optimal management is with surgical resection where possible. The role of post operative radiotherapy and chemotherapy is uncertain.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-023-03090-5","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T20:03:12Z","timestamp":1675281792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case report of an ischaemic stroke, caused by a primary cardiac intimal sarcoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Joshua","family":"Lloyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navinee","family":"Gilliat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"issue":"25","key":"3090_CR1","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1161\/CIRCULATIONAHA.115.016418","volume":"132","author":"G Oliveira","year":"2015","unstructured":"Oliveira G, Al-Kindi S, Hoimes C, et al. Characteristics and survival of malignant cardiac tumors. Circulation. 2015;132(25):2395\u2013402.","journal-title":"Circulation"},{"issue":"1","key":"3090_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13019-020-01157-4","volume":"15","author":"R Moeri-Schimmel","year":"2020","unstructured":"Moeri-Schimmel R, Pras E, Desar I, et al. Primary sarcoma of the heart: case report and literature review. J Cardiothorac Surg. 2020;15(1):1\u20136.","journal-title":"J Cardiothorac Surg"},{"key":"3090_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/461815","volume":"2013","author":"A Ibrahim","year":"2013","unstructured":"Ibrahim A, Luk A, Singhal P, et al. Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. Case Rep Med. 2013;2013:1\u20135.","journal-title":"Case Rep Med"},{"issue":"6","key":"3090_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.carpath.2013.04.006","volume":"22","author":"M Barreiro","year":"2013","unstructured":"Barreiro M, Renilla A, Jimenez J, et al. Primary cardiac tumors: 32 years of experience from a Spanish tertiary surgical center. Cardiovasc Pathol. 2013;22(6):424\u20137.","journal-title":"Cardiovasc Pathol"},{"issue":"11","key":"3090_CR5","doi-asserted-by":"publisher","first-page":"ytab410","DOI":"10.1093\/ehjcr\/ytab410","volume":"5","author":"K Ho","year":"2021","unstructured":"Ho K, Yatham K, Seno R, Sultan O. A case report of primary cardiac intimal sarcoma presenting with atrial fibrillation and a left atrial mass. Eur Heart J Case Rep. 2021;5(11):ytab410.","journal-title":"Eur Heart J Case Rep"},{"key":"3090_CR6","unstructured":"Intercollegiate Stroke Working Party. National clinical guideline for stroke, 5th edn. London: Royal College of Physicians; 2016, Choosing Wisely; p.\u00a0xvii."},{"key":"3090_CR7","unstructured":"Stroke Foundation. Australian and New Zealand Clinical Guidelines for Stroke Management. Melbourne; 2017. Chapter 2, Early assessment and diagnosis; [cited 2022 March 21]; Available from:\u00a0https:\/\/informme.org.au\/guidelines\/clinical-guidelines-for-stroke-management."},{"key":"3090_CR8","unstructured":"Sasse A, O'Meeghan T, Anscombe R, et al. Appropriateness Guideline for Adult Echocardiography (New Zealand). Wellington: Cardiac Society of Australia and New Zealand; 2017. Stroke - Cardiac source of embolism; [cited 2022 March 21]; p. 12. Available from:\u00a0https:\/\/cardiacsociety.org.nz\/wp-content\/uploads\/Echo-Appropriateness-Guidelines-NZ.pdf."},{"issue":"5","key":"3090_CR9","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/ana.20617","volume":"58","author":"H Ay","year":"2005","unstructured":"Ay H, Furie K, Singhal A, et al. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688\u201397.","journal-title":"Ann Neurol"},{"issue":"11","key":"3090_CR10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1470-2045(01)00561-7","volume":"2","author":"L Pickering","year":"2001","unstructured":"Pickering L, Cox I, Pandha H. Left atrial sarcoma presenting as cerebral infarction. Lancet Oncol. 2001;2(11):705\u20136.","journal-title":"Lancet Oncol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03090-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-023-03090-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03090-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T20:30:09Z","timestamp":1675283409000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-023-03090-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3090"],"URL":"https:\/\/doi.org\/10.1186\/s12872-023-03090-5","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]},"assertion":[{"value":"14 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed patient consent. Ethics committee approval Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We have written informed consent from the patient (before he passed away) to publish his case and associated investigations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author\u2019s declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"59"}}