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Autophagosomes were observed by transmission electron microscope. Mitochondrial membrane potential was detected by JC-1 staining. Apoptosis was detected by flow cytometry. Oxidative stress markers of MDA, SOD and GSH-PX were measured. The expression of LC3 and p62 was detected by immunofluorescence. Expression levels of Mst1, p-Mst1, Beclin1, LC3, and P62 were detected with Western blot.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared with the control group, the autophagosomes in HP, HP\u2009+\u2009Ad-Mst1, and HP\u2009+\u2009Ad-NC groups were significantly reduced. Compared with HP group, the autophagosomes in HP\u2009+\u2009Ad-Mst1 group were significantly reduced. The apoptosis of HP\u2009+\u2009MT group was significantly lower than HP group. Compared with HP\u2009+\u2009Ad-Mst1 group, the apoptosis of HP\u2009+\u2009Ad-Mst1\u2009+\u2009MT group was significantly reduced. The ratio of JC-1 monomer in HP\u2009+\u2009MT group was significantly lower than HP group. Compared with HP\u2009+\u2009Ad-Mst1 group, the mitochondrial membrane potential of HP\u2009+\u2009Ad-Mst1\u2009+\u2009MT group was also significantly reduced. MDA content in HP\u2009+\u2009MT group was significantly reduced, but SOD and GSH-PX activities were significantly increased. Compared with HP\u2009+\u2009Ad-Mst1 group, MDA content in HP\u2009+\u2009Ad-Mst1\u2009+\u2009MT group was significantly reduced, whereas SOD and GSH-PX activities were increased significantly. Mst1 and p-Mst1 proteins in HP\u2009+\u2009MT group were significantly reduced. Compared with HP\u2009+\u2009Ad-Mst1 group, Mst1 and p-Mst1 in HP\u2009+\u2009Ad-Mst1\u2009+\u2009MT group were reduced. P62 level was significantly decreased, while Beclin1 and LC3II levels were significantly increased. P62 in HP\u2009+\u2009MT group was significantly reduced, while Beclin1 and LC3II were significantly increased. Compared with HP\u2009+\u2009Ad-Mst1 group, P62 in HP\u2009+\u2009Ad-Mst1\u2009+\u2009MT group was significantly reduced, but Beclin1 and LC3II were significantly increased.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Melatonin may inhibit apoptosis, increase mitochondrial membrane potential, and increase autophagy of myocardial microvascular endothelial cells under hypertensive state via inhibiting Mst1 expression, thereby exerting myocardial protective effect.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-023-03159-1","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:47:39Z","timestamp":1680500859000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective effects of melatonin on myocardial microvascular endothelial cell injury under hypertensive state by regulating Mst1"],"prefix":"10.1186","volume":"23","author":[{"given":"Lingpeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"issue":"4","key":"3159_CR1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/HCO.0000000000000866","volume":"36","author":"KC Ferdinand","year":"2021","unstructured":"Ferdinand KC, Reddy TK, Vo TN. 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