{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:01:31Z","timestamp":1771592491258,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220703\/Z\/20\/Z"],"award-info":[{"award-number":["220703\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205188\/Z\/16\/Z"],"award-info":[{"award-number":["205188\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia as part of a first-pass stress perfusion study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>We enrolled 33 patients who had stress CMR. These patients had a baseline four-chamber cine and stress four-chamber cine, which was done at peak myocardial hyperaemic state after administering adenosine. The left and right atria were segmented in the end ventricular diastolic and systolic phases. Short-axis cine stack was segmented for ventricular functional assessment. At peak hyperaemic state, left atrial end ventricular systolic volume just before mitral valve opening increased significantly from baseline in all (91\u2009\u00b1\u200935ml vs. 81\u2009\u00b1\u200933ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002), in males only (99\u2009\u00b1\u200935ml vs. 88\u2009\u00b1\u200933ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and females only (70\u2009\u00b1\u200926ml vs. 62\u2009\u00b1\u200922ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). The right atrial end ventricular systolic volume increased less significantly from baseline (68\u2009\u00b1\u200921ml vs. 63\u2009\u00b1\u200920ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.0448). CMR-derived LVFP (equivalent to pulmonary capillary wedge pressure) increased significantly at the peak hyperaemic state in all (15.1\u2009\u00b1\u20092.9mmHg vs. 14.4\u2009\u00b1\u20092.8mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002), females only (12.9\u2009\u00b1\u20092.1mmHg vs. 12.3\u2009\u00b1\u20091.9mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.029) and males only (15.9\u2009\u00b1\u20092.8mmHg vs. 15.2\u2009\u00b1\u20092.7mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) cohorts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Left atrial volume assessment by CMR can measure acute and dynamic changes in preloading conditions on the left ventricle. During adenosine administered first-pass perfusion CMR, left atrial volume and LVFP rise significantly.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-023-03230-x","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T12:02:40Z","timestamp":1683806560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An acute increase in Left Atrial volume and left ventricular filling pressure during Adenosine administered myocardial hyperaemia: CMR First-Pass Perfusion Study"],"prefix":"10.1186","volume":"23","author":[{"given":"Pankaj","family":"Garg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosamadin","family":"Assadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Alabed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaran","family":"Grafton-Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Swift","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"Al-Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Sawh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios S","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Y","family":"Khanji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Plein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-169X","authenticated-orcid":false,"given":"Peter","family":"Swoboda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"3230_CR1","doi-asserted-by":"crossref","unstructured":"Leischik R, Littwitz H, Dworrak B, Garg P, Zhu M, Sahn DJ, Horlitz M. 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CMR measures of left atrial volume index and right ventricular function have Prognostic Value in Chronic Thromboembolic Pulmonary Hypertension. Front Med (Lausanne). 2022;9:840196.","journal-title":"Front Med (Lausanne)"},{"key":"3230_CR4","doi-asserted-by":"crossref","unstructured":"Garg P, Lewis RA, Johns CS, Swift AJ, Capener D, Rajaram S, Thompson AAR, Condliffe R, Elliot CA, Charalampopoulos A, Hameed AG, Rothman A, Wild JM, Kiely DG. Cardiovascular magnetic resonance predicts all-cause mortality in pulmonary hypertension associated with heart failure with preserved ejection fraction. Int J Cardiovasc Imaging. 2021 Oct;37(10):3019\u201325.","DOI":"10.1007\/s10554-021-02279-z"},{"key":"3230_CR5","doi-asserted-by":"publisher","unstructured":"Habibi M, Samiei S, Venkatesh BA, Opdahl A, Helle-Valle TM, Zareian M, Almeida ALC, Choi EY, Wu C, Alonso A, Heckbert SR, Bluemke DA, Lima JAC. CMR-Measured Left Atrial volume and function and Incident Atrial Fibrillation: results from the multi-ethnic study of atherosclerosis (MESA). Circ Cardiovasc Imaging. 2016 Aug;9(8). https:\/\/doi.org\/10.1161\/CIRCIMAGING.115.004299.","DOI":"10.1161\/CIRCIMAGING.115.004299"},{"key":"3230_CR6","doi-asserted-by":"crossref","unstructured":"Vassiliou VS, Pavlou M, Malley T, Halliday BP, Tsampasian V, Raphael CE, Tse G, Vieira MS, Auger D, Everett R, Chin C, Alpendurada F, Pepper J, Pennell DJ, Newby DE, Jabbour A, Dweck MR, Prasad SK. A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement. Sci Rep. 2021 Oct 12;11(1):20183.","DOI":"10.1038\/s41598-021-99788-7"},{"key":"3230_CR7","doi-asserted-by":"crossref","unstructured":"Garg P, Swift AJ. Importance of cardiac magnetic resonance imaging assessment of left ventricular filling pressure at resting state.Eur Heart J. 2022 Aug 4;ehac420.","DOI":"10.1093\/eurheartj\/ehac420"},{"key":"3230_CR8","doi-asserted-by":"crossref","unstructured":"Garg P, Gosling R, Swoboda P, Jones R, Rothman A, Wild JM, Kiely DG, Condliffe R, Alabed S, Swift AJ. Cardiac magnetic resonance identifies raised left ventricular filling pressure: prognostic implications. Eur Heart J. 2022 May;4:ehac207.","DOI":"10.1136\/heartjnl-2021-BSCMR.19"},{"key":"3230_CR9","doi-asserted-by":"crossref","unstructured":"Houltz E, Ricksten SE, Milocco I, Gustavsson T, Caidahl K. Effects of adenosine infusion on systolic and diastolic left ventricular function after coronary artery bypass surgery: evaluation by computer-assisted quantitative 2-D and doppler echocardiography. 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Circulation. 1995 Aug 1;92(3):371\u20139.","DOI":"10.1161\/01.CIR.92.3.371"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03230-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-023-03230-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-023-03230-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T12:03:39Z","timestamp":1683806619000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-023-03230-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,11]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3230"],"URL":"https:\/\/doi.org\/10.1186\/s12872-023-03230-x","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,11]]},"assertion":[{"value":"3 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PG has a clinical advisor role with Medis and Pie Medical Imaging. All other authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted as per the principles outlined in the 1964 Declaration of Helsinki. The study protocol was approved by the research ethics committee at the University of Leeds. Informed consent was obtained from all subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"246"}}