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We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (\u2265\u20099.5\u00a0pg\/mL) and low levels IL-6 group (&lt;\u20099.5\u00a0pg\/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3\u2009\u00b1\u200911.0\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0\u00a0pg\/mL. High levels of IL-6 were significantly associated with high levels of GS (&gt;\u200940) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6\u2009\u00b1\u200939.5\n                      <jats:italic>vs<\/jats:italic>\n                      46.7\u2009\u00b1\u200937.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). The analysis of the ROC curve performed in myocardial infarction patients showed that IL-6 (AUC: 0.941 (CI 95% 0.886, 0.997;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction when compared to myonecrosis biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Number: NCT03075566 (09\/03\/2017).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-023-03570-8","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:02:58Z","timestamp":1701169378000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-7279","authenticated-orcid":false,"given":"Nadia","family":"Bouzidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Gamra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"3570_CR1","doi-asserted-by":"publisher","first-page":"402","DOI":"10.14744\/AnatolJCardiol.2017.7935","volume":"18","author":"N Bouzidi","year":"2017","unstructured":"Bouzidi N, Betbout F, Maatouk F. 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