{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:13:07Z","timestamp":1772165587741,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis and thrombo-embolic disease are well known complications of thalassemia major. Intracardiac thrombi are however rare and can lead to diagnostic dilemmas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 20-year-old female splenectomised thalassaemia major patient with severe iron overload, who presented with life threatening sepsis associated with a liver abscess. Discovery of a large oscillating intra cardiac lesion on 2D echocardiogram confirmed by Contrast Enhanced Computed Tomography (CECT) chest in the right atrium extending from the left hepatic vein through the inferior vena cava complicated the clinical course. After a prolonged Intensive Care Unit (ICU) stay supported with antibiotics and anticoagulation, she recovered with evidence of resolution of the intra cardiac thrombus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early recognition and prompt aggressive treatment of sepsis in patients with thalassemia is essential to prevent complications. Intracardiac thrombosis is a potentially treatable cause for an intra cardiac mass in patients with thalassemia major, which should not be missed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-023-03576-2","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T13:01:51Z","timestamp":1698757311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extensive systemic thrombo-embolism including intra-cardiac thrombosis mimicking an atrial myxoma in a patient with beta thalassaemia major \u2013 a case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Chiranthi","family":"Welhenge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumesh","family":"Ranasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeewa","family":"Rajapakse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Premawardhena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"issue":"1","key":"3576_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/jcm11010015","volume":"11","author":"F Tedone","year":"2021","unstructured":"Tedone F, Lamendola P, Lopatriello S, Cafiero D, Piovani D, Forni GL. Quality of Life and Burden of Disease in Italian Patients with Transfusion-Dependent Beta-Thalassemia. J Clin Med. 2021;11(1):15. https:\/\/doi.org\/10.3390\/jcm11010015. (PMID: 35011757; PMCID: PMC8745153).","journal-title":"J Clin Med"},{"key":"3576_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/ejh.13410","volume":"105","author":"D Farmakis","year":"2020","unstructured":"Farmakis D, Giakoumis A, Angastiniotis M, Eleftheriou A. The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation. Eur J Haematol. 2020;105:16\u201323. https:\/\/doi.org\/10.1111\/ejh.13410.","journal-title":"Eur J Haematol"},{"key":"3576_CR3","doi-asserted-by":"publisher","unstructured":"Farrukh T. Shah, Farzana Sayani, Sara Trompeter, Emma Drasar, Antonio Piga, Challenges of blood transfusions in \u03b2-thalassemia. 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Advances in the prevention and treatment are changing thalassemia from a fatal to a chronic disease experience from a cyprus model and its use as a paradigm for future applications. Hemoglobin. 2009;33(5):287\u201395. https:\/\/doi.org\/10.3109\/03630260903212043.","journal-title":"Hemoglobin"},{"key":"3576_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/0974-5009.126696","volume":"41","author":"R Aggarwal","year":"2014","unstructured":"Aggarwal R, Prakash A, Aggarwal M. Thalassemia: An overview. J Sci Soc. 2014;41:3\u20136.","journal-title":"J Sci Soc"},{"issue":"1","key":"3576_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1182\/asheducation-2004.1.14","volume":"2004","author":"AR Cohen","year":"2004","unstructured":"Cohen AR, Galanello R, Pennell DJ, Cunningham MJ. Elliott Vichinsky; Thalassemia. 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Informed written consent was taken from her mother who is her next of kin for publication of her clinical details and any relevant images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"532"}}