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We hypothesized that arterial stiffness as measured by cardio-ankle vascular index (CAVI) could be an independent predictor of HRE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Retrospective chart review of patients participated in the preventive health program at the Bangkok Heart Hospital who underwent both CAVI and treadmill stress testing on the same day between June and December 2018 were performed. Variables for the prediction of HRE were analyzed using univariate analysis, and significant variables were entered into multiple logistic regression. An ROC curve was created to test the sensitivity and specificity of CAVI as a predictor of HRE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 285 participants (55.1% female) were enrolled in this study. There were 58 patients (20.4%) who met the HRE definition (SBP\u2009&gt;\u2009210\u00a0mmHg in males, SBP\u2009&gt;\u2009190\u00a0mmHg in females, or DBP\u2009&gt;\u2009110\u00a0mmHg in both males and females), with a mean age of 46.4 12.8\u00a0years. In univariate analysis, age, systolic blood pressure at rest, diastolic blood pressure at rest, pulse pressure at rest, diabetes mellitus, hypertension, dyslipidemia, history of beta-blocker, and CAVI results were statistically significant. Multiple logistic regression revealed that CAVI and systolic blood pressure were statistically significant predictors of HRE with OR of 5.8, 95%CI: 2.9\u201311.7,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and OR 1.07, 95%CI: 1.03\u20131.10,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001 respectively. ROC curve analysis of the CAVI revealed an AUC of 0.827 (95%CI: 0.76\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the sensitivity and specificity of cut-point CAVI\u2009&gt;\u20098 were 53% and 92%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that CAVI is an independent predictor of hypertensive response to exercise. Additionally, the findings suggest that CAVI\u2009&gt;\u20098 can be a valuable tool in identifying individuals at risk for hypertensive responses during exercise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-024-03807-0","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:02:43Z","timestamp":1710817363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CAVI (Cardio-Ankle Vascular Index) as an independent predictor of hypertensive response to exercise"],"prefix":"10.1186","volume":"24","author":[{"given":"C.","family":"Wuttichaipradit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yodwut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sukhum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hengrussamee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Treesong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thiangtham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Samut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tunhasiriwet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yingchoncharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"4","key":"3807_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jacc.2008.03.052","volume":"52","author":"CY Shim","year":"2008","unstructured":"Shim CY, Ha JW, Park S, et al. 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All participants were waived the need of inform consent in accordance with the relevant guidelines and regulations. The IRB protocol number is BMC-IRB 2017\u201307-023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare having no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"165"}}