{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:20:32Z","timestamp":1780420832833,"version":"3.54.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aortic valve reconstruction using glutaraldehyde-treated autologous pericardium, also called Ozaki procedure, is a surgical procedure for patients with aortic valve disease. Gratifying results have been reported in adult patients, however, limited published data is available in paediatric population. This study looked at clinical characteristics and early outcomes of children who underwent Ozaki procedure at our Institute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective descriptive study conducted on children who underwent aortic valve reconstruction at Jakaya Kikwete Cardiac Institute (JKCI) from January 2019 through December 2022. Medical records of these children were reviewed to extract data on demographics, clinical characteristics, redo surgical interventions and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10 children underwent Ozaki procedure during the study period. Eight children had severe aortic regurgitation while 2 had severe aortic stenosis preoperatively. All children had either none or trivial aortic regurgitation immediately after surgery. None of them had redone operations throughout the follow-up period. There was no in-hospital mortality, however, one child died one-year after surgery. The mean follow-up period was 1.6 years with the longest follow-up time of 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ozaki procedure showed encouraging early results among children with aortic valve disease who underwent surgical repair by this technique. Future studies with larger sample sizes and longer follow up periods to evaluate long-term results in this population are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-024-03829-8","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:51:21Z","timestamp":1710816681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes post Ozaki procedure among children with aortic valve disease at Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania: a retrospective descriptive study"],"prefix":"10.1186","volume":"24","author":[{"given":"Zawadi Edward","family":"Kalezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphonce Nsabi","family":"Simbila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mongella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deogratias","family":"Nkya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin","family":"Sharau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Shonyela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"Mlawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naizihijwa","family":"Majani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"3829_CR1","doi-asserted-by":"crossref","unstructured":"Wang K, Zhang H, Jia B. Current surgical strategies and techniques of aortic valve diseases in children. 2018;7(2):83\u201390.","DOI":"10.21037\/tp.2018.02.03"},{"key":"3829_CR2","unstructured":"Allen HD, Shaddy RE, Penny DJ, Feltes TF, Cetta F. Heart disease in infants, children and adolescents. 1. 2016. 1374\u2013402 p."},{"key":"3829_CR3","doi-asserted-by":"crossref","unstructured":"Zuechner A, Mhada T, Majani NG, Sharau GG, Mahalu W, Freund MW. Spectrum of heart diseases in children presenting to a paediatric cardiac echocardiography clinic in the Lake Zone of Tanzania: a 7 years overview. 2019;4:4\u20139.","DOI":"10.21203\/rs.2.13694\/v1"},{"key":"3829_CR4","doi-asserted-by":"crossref","unstructured":"Pushpa J, Bhat A, Simha PP, Manjunatha MPS. N. Perioperative echocardiography in Ozaki \u2019 s procedure: an observational study - single centre experience. 2019;11(September):268\u201373.","DOI":"10.26611\/101511314"},{"issue":"1","key":"3829_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jtcvs.2015.09.083","volume":"151","author":"JRG Etnel","year":"2015","unstructured":"Etnel JRG, Elmont LC, Ertekin E, Mokhles MM. Outcome after aortic valve replacement in children: a systematic review and outcome after aortic valve replacement in children : a systematic review and meta-analysis. J Thorac Cardiovasc Surg. 2015;151(1):143\u201352.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"3829_CR6","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.athoracsur.2004.11.042","volume":"79","author":"S Talwar","year":"2005","unstructured":"Talwar S, Saikrishna C, Saxena A, Kumar AS. Aortic valve repair for rheumatic aortic valve. Ann Thorac Surg. 2005;79:1921\u20135.","journal-title":"Ann Thorac Surg"},{"key":"3829_CR7","doi-asserted-by":"crossref","unstructured":"Bacha EA, McElhinney DB, Guleserian KJ, Colan SD, Jonas RA, del Nido PJ et al. Surgical aortic valvuloplasty in children and adolescents with aortic regurgitation: Acute and intermediate effects on aortic valve function and left ventricular dimensions. J Thorac Cardiovasc Surg. 2008;135(3).","DOI":"10.1016\/j.jtcvs.2007.09.057"},{"issue":"July","key":"3829_CR8","first-page":"1504","volume":"79","author":"S Ozaki","year":"2015","unstructured":"Ozaki S, Kawase I, Yamashita H, Uchida S, Takatoh M, Hagiwara S, et al. Aortic Valve Reconstruction Using Autologous Pericardium Aortic Stenosis. 2015;79(July):1504\u201310.","journal-title":"Aortic Valve Reconstruction Using Autologous Pericardium Aortic Stenosis"},{"key":"3829_CR9","doi-asserted-by":"crossref","unstructured":"Al Halees Z, Al Shahid M, Al Sanei A, Sallehuddin A, Duran C. Up to 16 years follow-up of aortic valve reconstruction with pericardium: a stentless readily available cheap valve ? 2005;28:200\u20135.","DOI":"10.1016\/j.ejcts.2005.04.041"},{"issue":"6","key":"3829_CR10","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1016\/j.jtcvs.2019.09.176","volume":"159","author":"LM Wiggins","year":"2020","unstructured":"Wiggins LM, Mimic B, Issitt R, Ilic S, Bonello B, Marek J, et al. The utility of aortic valve leaflet reconstruction techniques in children and young adults. J Thorac Cardiovasc Surg. 2020;159(6):2369\u201378.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"3829_CR11","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s00246-020-02528-3","volume":"42","author":"A Polito","year":"2021","unstructured":"Polito A, Albanese SB, Cetrano E, Forcina S, Cicenia M, Rinelli G, et al. Aortic valve neocuspidalization may be a viable alternative to Ross Operation in Pediatric patients. Pediatr Cardiol. 2021;42(3):668\u201375.","journal-title":"Pediatr Cardiol"},{"issue":"6","key":"3829_CR12","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1016\/j.jtcvs.2018.01.087","volume":"155","author":"S Ozaki","year":"2018","unstructured":"Ozaki S, Kawase I, Yamashita H, Uchida S. Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium. J Thorac Cardiovasc Surg. 2018;155(6):2379\u201387.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"3829_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ejcts.2009.06.021","volume":"37","author":"D Aicher","year":"2010","unstructured":"Aicher D, Fries R, Rodionycheva S, Schmidt K, Langer F, Sch\u00e4fers HJ. Aortic valve repair leads to a low incidence of valve-related complications. Eur J Cardio-thoracic Surg. 2010;37(1):127\u201332.","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"3829_CR14","doi-asserted-by":"crossref","unstructured":"Chivers SC, Pavy C, Vaja R, Quarto C, Ghez O, Daubeney PEF. The Ozaki Procedure with CardioCel Patch for children and young adults with aortic valve disease: preliminary experience \u2013 a word of caution. 2019;10(6):724\u201330.","DOI":"10.1177\/2150135119878108"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03829-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-03829-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03829-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:52:13Z","timestamp":1710816733000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-03829-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3829"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-03829-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3012978\/v1","asserted-by":"object"}]},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"assertion":[{"value":"2 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval to conduct the study was obtained from Ethics Review Committee of the Jakaya Kikwete Cardiac Institute (Ref.No.AB.123\/307\/38). All patients received treatment as per standard Institutional policies. We are confirming that all methods were carried out in accordance with relevant guidelines and regulations. Informed consent of participation in the study was obtained from the patients\u2019 and \/or their legal guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"163"}}