{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:28:09Z","timestamp":1787020089019,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018935","name":"Universit\u00e4tsklinikum Erlangen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adults with congenital heart defects (ACHD) globally constitute a notably medically underserved patient population. Despite therapeutic advancements, these individuals often confront substantial physical and psychosocial residua or sequelae, requiring specialized, integrative cardiological care throughout their lifespan. Heart failure (HF) is a critical challenge in this population, markedly impacting morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The primary aim of this study is to establish a comprehensive, prospective registry to enhance understanding and management of HF in ACHD. Named PATHFINDER-CHD, this registry aims to establish foundational data for treatment strategies as well as the development of rehabilitative, prehabilitative, preventive, and health-promoting interventions, ultimately aiming to mitigate the elevated morbidity and mortality rates associated with congenital heart defects (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter survey will be conducted across various German university facilities with expertise in ACHD. Data collection will encompass real-world treatment scenarios and clinical trajectories in ACHD with manifest HF or at risk for its development, including those undergoing medical or interventional cardiac therapies, cardiac surgery, inclusive of pacemaker or ICD implantation, resynchronization therapy, assist devices, and those on solid organ transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The study adopts an observational, exploratory design, prospectively gathering data from participating centers, with a focus on patient management and outcomes. The study is non-confirmatory, aiming to accumulate a broad spectrum of data to inform future hypotheses and studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Processes<\/jats:title>\n                    <jats:p>Regular follow-ups will be conducted, systematically collecting data during routine clinical visits or hospital admissions, encompassing alterations in therapy or CHD-related complications, with visit schedules tailored to individual clinical needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessments<\/jats:title>\n                    <jats:p>Baseline assessments and regular follow-ups will entail comprehensive assessments of medical history, ongoing treatments, and outcomes, with a focus on HF symptoms, cardiac function, and overall health status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion of the design<\/jats:title>\n                    <jats:p>The design of the PATHFINDER-CHD Registry is tailored to capture a wide range of data, prioritizing real-world HF management in ACHD. Its prospective nature facilitates longitudinal data acquisition, pivotal for comprehending for disease progression and treatment impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PATHFINDER-CHD Registry is poised to offer valuable insights into HF management in ACHD, bridging current knowledge gaps, enhancing patient care, and shaping future research endeavors in this domain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-024-03833-y","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T04:06:29Z","timestamp":1711425989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and\/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods"],"prefix":"10.1186","volume":"24","author":[{"given":"Sebastian","family":"Freilinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Kaemmerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Pittrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Achenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Freiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gorenflo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Harig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Holdenrieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"H\u00f6rer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Huntgeburth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00fcbler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niko","family":"Kohls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Klawonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Kozlik-Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Kaulitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lo\u00dfnitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Mellert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Nagdyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Nordmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Pittrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Pittrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Rickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rosenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Schelling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Sinning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu N.","family":"Suleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yskert","family":"von Kodolitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"von Scheidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-7632","authenticated-orcid":false,"given":"Ann-Sophie","family":"Kaemmerer-Suleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"3833_CR1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-0042-121501","volume":"142","author":"R Neidenbach","year":"2017","unstructured":"Neidenbach R, Kaemmerer H, Pieper L, Ewert P. Schelling J [Striking Supply Gap in Adults with Congenital Heart Disease?]. Dtsch Med Wochenschr. 2017;142:301\u20133.","journal-title":"Dtsch Med Wochenschr"},{"key":"3833_CR2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.21037\/cdt.2018.10.15","volume":"8","author":"R Neidenbach","year":"2018","unstructured":"Neidenbach R, Niwa K, Oto O, Oechslin E, Aboulhosn J, Celermajer D, et al. Improving medical care and prevention in adults with congenital heart disease-reflections on a global problem-part I: development of congenital cardiology, epidemiology, clinical aspects, heart failure, cardiac arrhythmia. Cardiovasc Diagn Ther. 2018;8:705\u201315.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR3","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3390\/jcm9061943","volume":"9","author":"L Seidel","year":"2020","unstructured":"Seidel L, Nebel K, Achenbach S, Bauer U, Ewert P, Freilinger S, et al. Facts about the General Medical Care of Adults with Congenital Heart Defects: Experience of a Tertiary Care Center. J Clin Med. 2020;9:1943.","journal-title":"J Clin Med"},{"key":"3833_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2217\/fca-2019-0061","volume":"16","author":"RJ Henning","year":"2020","unstructured":"Henning RJ. Diagnosis and treatment of adults with congenital heart disease. Future Cardiol. 2020;16:317\u201342.","journal-title":"Future Cardiol"},{"key":"3833_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12963-015-0063-z","volume":"13","author":"CP Benziger","year":"2015","unstructured":"Benziger CP, Stout K, Zaragoza-Macias E, Bertozzi-Villa A, Flaxman AD. Projected growth of the adult congenital heart disease population in the United States to 2050: an integrative systems modeling approach. Popul Health Metr. 2015;13:29.","journal-title":"Popul Health Metr"},{"key":"3833_CR6","doi-asserted-by":"crossref","unstructured":"Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, et al. [Medical care of adults with congenital heart diseases\u202f: Present and future].. 2019;44:553\u201372.","DOI":"10.1007\/s00059-019-4820-9"},{"key":"3833_CR7","doi-asserted-by":"publisher","first-page":"716","DOI":"10.21037\/cdt.2018.10.16","volume":"8","author":"R Neidenbach","year":"2018","unstructured":"Neidenbach R, Niwa K, Oto O, Oechslin E, Aboulhosn J, Celermajer D, et al. Improving medical care and prevention in adults with congenital heart disease-reflections on a global problem-part II: infective endocarditis, pulmonary hypertension, pulmonary arterial hypertension and aortopathy. Cardiovasc Diagn Ther. 2018;8:716\u201324.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR8","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.jacc.2018.08.1028","volume":"73","author":"KK Stout","year":"2019","unstructured":"Stout KK, Daniels CJ, Aboulhosn JA, Bozkurt B, Broberg CS, Colman JM, et al. 2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73:1494\u2013563.","journal-title":"J Am Coll Cardiol"},{"key":"3833_CR9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1055\/a-2146-7434","volume":"77","author":"H Kaemmerer","year":"2023","unstructured":"Kaemmerer H, Diller GP, D\u00e4hnert I, Eichstaedt CA, Eicken A, et al. Freiberger A [Pulmonary arterial hypertension in congenital heart disease - Part I]. Pneumologie. 2023;77:956\u201361.","journal-title":"Pneumologie"},{"key":"3833_CR10","doi-asserted-by":"publisher","first-page":"814","DOI":"10.21037\/cdt.2018.09.12","volume":"8","author":"S Singh","year":"2018","unstructured":"Singh S, Desai R, Fong HK, Sadolikar A, Samani S, Goyal H. Extra-cardiac comorbidities or complications in adults with congenital heart disease: a nationwide inpatient experience in the United States. Cardiovasc Diagn Ther. 2018;8:814\u20139.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.21037\/cdt.2018.03.11","volume":"8","author":"RC Neidenbach","year":"2018","unstructured":"Neidenbach RC, Lummert E, Vigl M, Zachoval R, Fischereder M, Engelhardt A, et al. Non-cardiac comorbidities in adults with inherited and congenital heart disease: report from a single center experience of more than 800 consecutive patients. Cardiovasc Diagn Ther. 2018;8:423\u201331.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.21037\/cdt.2018.12.06","volume":"8","author":"C Andonian","year":"2018","unstructured":"Andonian C, Beckmann J, Biber S, Ewert P, Freilinger S, Kaemmerer H, et al. Current research status on the psychological situation of adults with congenital heart disease. Cardiovasc Diagn Ther. 2018;8:799\u2013804.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ijcard.2016.02.133","volume":"211","author":"CC Engelings","year":"2016","unstructured":"Engelings CC, Helm PC, Abdul-Khaliq H, Asfour B, Bauer UMM, Baumgartner H, et al. Cause of death in adults with congenital heart disease - An analysis of the German National Register for Congenital Heart Defects. Int J Cardiol. 2016;211:31\u20136.","journal-title":"Int J Cardiol"},{"key":"3833_CR14","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1586\/14779072.2016.1133294","volume":"14","author":"M Ministeri","year":"2016","unstructured":"Ministeri M, Alonso-Gonzalez R, Swan L, Dimopoulos K. Common long-term complications of adult congenital heart disease: avoid falling in a H.E.A.P. Expert Rev Cardiovasc Ther. 2016;14:445\u201362.","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"3833_CR15","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1016\/j.ijcard.2013.03.003","volume":"168","author":"AC Zomer","year":"2013","unstructured":"Zomer AC, Vaartjes I, van der Velde ET, de Jong HMY, Konings TC, Wagenaar LJ, et al. Heart failure admissions in adults with congenital heart disease; risk factors and prognosis. Int J Cardiol. 2013;168:2487\u201393.","journal-title":"Int J Cardiol"},{"key":"3833_CR16","first-page":"329","volume":"66","author":"A Faccini","year":"2018","unstructured":"Faccini A, Micheletti A, Negura DG, Giugno L, Butera G, Carminati M, et al. Heart failure in grown-up congenital heart disease. Minerva Cardioangiol. 2018;66:329\u201336.","journal-title":"Minerva Cardioangiol"},{"key":"3833_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10741-017-9664-x","volume":"23","author":"A Van De Bruaene","year":"2018","unstructured":"Van De Bruaene A, Meier L, Droogne W, De Meester P, Troost E, Gewillig M, et al. Management of acute heart failure in adult patients with congenital heart disease. Heart Fail Rev. 2018;23:1\u201314.","journal-title":"Heart Fail Rev"},{"key":"3833_CR18","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1093\/eurheartj\/ehv741","volume":"37","author":"W Budts","year":"2016","unstructured":"Budts W, Roos-Hesselink J, R\u00e4dle-Hurst T, Eicken A, McDonagh TA, Lambrinou E, et al. Treatment of heart failure in adult congenital heart disease: a position paper of the Working Group of Grown-Up Congenital Heart Disease and the Heart Failure Association of the European Society of Cardiology. Eur Heart J. 2016;37:1419\u201327.","journal-title":"Eur Heart J"},{"key":"3833_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/CIRCULATIONAHA.117.031544","volume":"137","author":"M Brida","year":"2018","unstructured":"Brida M, Diller G-P, Gatzoulis MA. Systemic Right Ventricle in Adults With Congenital Heart Disease: Anatomic and Phenotypic Spectrum and Current Approach to Management. Circulation. 2018;137:508\u201318.","journal-title":"Circulation"},{"key":"3833_CR20","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s12181-023-00617-0","volume":"17","author":"H Kaemmerer","year":"2023","unstructured":"Kaemmerer H, Baldus S, Baumgartner H, Berger F, de Haan F, Frantz S, et al. \u201eErwachsene mit angeborenen Herzfehlern\u201c: Aktuelle Herausforderung in der medizinischen Versorgung Teil II: Infekti\u00f6se Endokarditis, pulmonale Hypertonie, Aortopathien, herzchirurgische Aspekte, Psychokardiologie, ungel\u00f6ste Probleme und Zukunftsaspekte. Kardiologie. 2023;17:282\u201399.","journal-title":"Kardiologie"},{"key":"3833_CR21","doi-asserted-by":"publisher","first-page":"E11","DOI":"10.1111\/chd.12189","volume":"10","author":"G Derk","year":"2015","unstructured":"Derk G, Houser L, Miner P, Williams R, Moriarty J, Finn P, et al. Efficacy of endothelin blockade in adults with Fontan physiology. Congenit Heart Dis. 2015;10:E11-16.","journal-title":"Congenit Heart Dis"},{"key":"3833_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/europace\/euw386","volume":"20","author":"Z Koyak","year":"2018","unstructured":"Koyak Z, de Groot JR, Krimly A, Mackay TM, Bouma BJ, Silversides CK, et al. Cardiac resynchronization therapy in adults with congenital heart disease. Europace. 2018;20:315\u201322.","journal-title":"Europace"},{"key":"3833_CR23","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.cjca.2014.09.002","volume":"30","author":"P Khairy","year":"2014","unstructured":"Khairy P, Van Hare GF, Balaji S, Berul CI, Cecchin F, Cohen MI, et al. PACES\/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD). Can J Cardiol. 2014;30:e1-63.","journal-title":"Can J Cardiol"},{"key":"3833_CR24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.healun.2017.11.010","volume":"37","author":"A Cedars","year":"2018","unstructured":"Cedars A, Vanderpluym C, Koehl D, Cantor R, Kutty S, Kirklin JK. An Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of hospitalization, functional status, and mortality after mechanical circulatory support in adults with congenital heart disease. J Heart Lung Transplant. 2018;37:619\u201330.","journal-title":"J Heart Lung Transplant"},{"key":"3833_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.healun.2017.03.005","volume":"37","author":"CJ VanderPluym","year":"2018","unstructured":"VanderPluym CJ, Cedars A, Eghtesady P, Maxwell BG, Gelow JM, Burchill LJ, et al. Outcomes following implantation of mechanical circulatory support in adults with congenital heart disease: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). J Heart Lung Transplant. 2018;37:89\u201399.","journal-title":"J Heart Lung Transplant"},{"key":"3833_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.21037\/acs.2018.01.01","volume":"7","author":"R Bryant","year":"2018","unstructured":"Bryant R, Morales D. Overview of adult congenital heart transplants. Ann Cardiothorac Surg. 2018;7:143\u201351.","journal-title":"Ann Cardiothorac Surg"},{"key":"3833_CR27","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.3390\/jcm10102192","volume":"10","author":"B Rauch","year":"2021","unstructured":"Rauch B, Salzwedel A, Bjarnason-Wehrens B, Albus C, Meng K, Schmid J-P, et al. Cardiac Rehabilitation in German Speaking Countries of Europe-Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 1. J Clin Med. 2021;10:2192.","journal-title":"J Clin Med"},{"key":"3833_CR28","doi-asserted-by":"publisher","first-page":"481","DOI":"10.21037\/cdt-20-825","volume":"11","author":"R Neidenbach","year":"2021","unstructured":"Neidenbach R, Achenbach S, Andonian C, Bauer UMM, Ewert P, Freilinger S, et al. Systematic assessment of health care perception in adults with congenital heart disease in Germany. Cardiovasc Diagn Ther. 2021;11:481\u201391.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR29","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.21037\/cdt-20-727","volume":"11","author":"S Freilinger","year":"2021","unstructured":"Freilinger S, Andric D, Andonian C, Beckmann J, Bongarth C, Einwang HP, et al. Lessons from the short- and mid-term outcome of medical rehabilitation in adults with congenital heart disease. Cardiovasc Diagn Ther. 2021;11:1416\u201331.","journal-title":"Cardiovasc Diagn Ther"},{"key":"3833_CR30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1055\/s-0034-1396815","volume":"77","author":"E Alegria","year":"2015","unstructured":"Alegria E, Gothe H, Geyer S, Jaunzeme J, Maier M, Grobe T, et al. Good Practice of Secondary Data Analysis (GPS): guidelines and recommendations. Gesundheitswesen. 2015;77:120\u20136.","journal-title":"Gesundheitswesen"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03833-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-03833-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03833-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T04:07:19Z","timestamp":1711426039000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-03833-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3833"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-03833-y","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"27 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The registry's documentation, including the protocol, patient information, informed consent form (ICF), and other requisite materials, received approval from the primary ethics committee (Ethics Committee of the Technical University Munich, number 2022\u2013582-S-KH). New participating sites must obtain additional ethics approval from their respective local authorities as needed. Any modifications to the protocol will undergo the same approval process as the initial protocol. Patient eligibility for inclusion in the study is contingent upon providing written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"181"}}