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A subset also underwent cardiovascular magnetic resonance imaging (CMR) after 6 months. Cardiac abnormalities were defined as left ventricular hypertrophy or dysfunction, right ventricular dysfunction, or CMR late gadolinium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 189 patients with hs-cTnT concentrations measured during hospitalization for COVID-19, and after 3-and 12 months: Geometric mean (95%CI) 13 (11\u201315) ng\/L, 7 (6\u20138) ng\/L and 7 (6\u20138) ng\/L, respectively. Cardiac abnormalities after 3 months were present in 45 (30%) and 3 (8%) of patients with hs-cTnT\u2009\u2265\u2009and &lt;\u20095 ng\/L at 3 months, respectively (negative predictive value 92.3% [95%CI 88.5\u201396.1%]). The performance was similar in patients with and without dyspnea. Hs-cTnT decreased from hospitalization to 3 months (more pronounced in intensive care unit-treated patients) and remained unchanged from 3 to 12 months, regardless of the presence of cardiac abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher hs-cTnT concentrations in the convalescent phase of COVID-19 are associated with the presence of cardiac pathology and low concentrations (&lt;\u20095 ng\/L) may support in ruling out cardiac pathology following the infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-024-03854-7","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T03:02:21Z","timestamp":1712977341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trajectory of cardiac troponin T following moderate-to-severe COVID-19 and the association with cardiac abnormalities"],"prefix":"10.1186","volume":"24","author":[{"given":"Tarjei","family":"\u00d8vrebotten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albulena","family":"Mecinaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Stavem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eivind","family":"Br\u00f8nstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Durheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f8ri V.","family":"Lerum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Josefsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jostein","family":"Grimsmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri L.","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte B.","family":"Ingul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Einvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder L.","family":"Myhre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"issue":"26","key":"3854_CR1","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1056\/nejmoa0805299","volume":"361","author":"T Omland","year":"2009","unstructured":"Omland T, De Lemos JA, Sabatine MS, Christophi CA, Rice MM, Jablonski KA, et al. 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Informed consent was obtained from all participants, which was given by returning a written signed consent form. Data was stored and post-processed in Services for Sensitive Data (TSD; University of Oslo), in compliance with the Norwegian Personal Data Act and Health Research Act.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"P.L.M has served on advisory boards and\/or received speaker fees from Amarin, AmGen, AstraZeneca, Bayer, Boehringer Ingelheim, Novartis, Novo Nordisk, Pharmacosmos, Vifor and Us2.ai, unrelated to this work. C.I and J.G have received fees for lectures from Bayer AG. J.G has received fees for participating in an expert panel from Sanofi, unrelated to this work. S.A. has received speaker honoraria from Bayer and Novartis. T.O. has received consultancy and speaker honoraria from Abbott Diagnostics, Roche Diagnostics, and Novartis, and research support via Akershus University Hospital from Thermo Fisher BRAHMS, HyTest Ltd., Biomedica, Abbott Diagnostics, Novartis, Singulex, SomaLogic, and Roche Diagnostics. T. O. also has financial interests in Cardinor AS, which holds the license to commercialize secretoneurin. Waleed Ghanima reports fees for participation in Advisory board from Amgen, Novartis, Pfizer, Principia Biopharma Inc- a Sanofi Company, Sanofi, SOBI, Grifols, UCB, Argenx, Cellphire. Lecture honoraria from Amgen, Novartis, Pfizer, Bristol Myers Squibb, SOBI, Grifols, Sanofi, and Bayer, and have received research grants from Bayer, BMS\/Pfizer, and UCB. All other authors report no disclosures.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"206"}}