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All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes <jats:italic>(Systems Genomics, Cardiac-GeneSGKit\u00ae).<\/jats:italic> It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance imaging (MRI) parameters between patients with the genes variants and those without. 2D echocardiography and MRI were used to analyze myocardial mechanics and morphometrics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study group consisted of 95 patients with NIDCM and the average age was 49.7\u2009\u00b1\u200910.5. All echocardiographic and MRI parameters of myocardial mechanics (left ventricular ejection fraction 28.4\u2009\u00b1\u20098.7 and 30.7\u2009\u00b1\u200911.2, respectively) were reduced and all values of cardiac chambers were increased (left ventricular end-diastolic diameter 64.5\u2009\u00b1\u20095.9\u00a0mm and 69.5\u2009\u00b1\u200910.7\u00a0mm, respectively) in this group. It was noticed that most cases of whole-heart myocardial mechanics and morphometrics differences between patients with and without gene variants were in the genes <jats:italic>GATAD1<\/jats:italic>, <jats:italic>LOX<\/jats:italic>, <jats:italic>RASA1<\/jats:italic>, <jats:italic>KRAS<\/jats:italic>, and <jats:italic>KRIT1<\/jats:italic>. These genes have not been previously linked to DCM. It has emerged that <jats:italic>KRAS<\/jats:italic> and <jats:italic>KRIT1<\/jats:italic> genes were associated with worse whole-heart mechanics and enlargement of all heart chambers. <jats:italic>GATAD1<\/jats:italic>, <jats:italic>LOX<\/jats:italic>, and <jats:italic>RASA1<\/jats:italic> genes variants showed an association with better cardiac function and morphometrics parameters. It might be that these variants alone do not influence disease development enough to be selective in human evolution.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Combined variants in previously unreported genes related to DCM might play a significant role in affecting clinical, morphometrics, or myocardial mechanics parameters.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-024-03888-x","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T05:01:52Z","timestamp":1714021312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy"],"prefix":"10.1186","volume":"24","author":[{"given":"Karolina","family":"M\u0117linyt\u0117-Ankudavi\u010d\u0117","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"\u0160ukys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel\u0117","family":"Kasputyt\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri\u010dardas","family":"Krik\u0161tolaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egl\u0117","family":"Ereminien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gryt\u0117","family":"Galnaitien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaida","family":"Mizarien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gintar\u0117","family":"\u0160akalyt\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Krilavi\u010dius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaldas","family":"Jurkevi\u010dius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"3888_CR1","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","volume":"37","author":"YM Pinto","year":"2016","unstructured":"Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, Bo\u00a8hm M, Duboc D, Gimeno J, de Groote P, Imazio M, et al. 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