{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:29:07Z","timestamp":1788568147646,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension (HT) is one of the most common manifestations in patients with catecholamine-secreting neuroendocrine tumors. Although the cardiovascular manifestations of these tumors have been described, there have been no large-scale investigations of the profile of HT and changes in cardiac structure and function that occur in patients with pheochromocytomas and paragangliomas (PPGL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this study, we investigated the prevalence of HT and left ventricular remodeling (LVR) in a cohort of 598 patients who underwent surgery for PPGL at our center between January 2001 and April 2022. Information on demographics, reason for hospitalization, medical history, biochemical parameters, findings on echocardiography, and tumor characteristics were recorded. The LVR index was compared according to whether or not there was a history of HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average age was 47.07\u2009\u00b1\u200915.07 years, and 277 (46.32%) of the patients were male. A history of HT was found in 423 (70.74%) of the 598 patients. Paraganglioma was significantly more common in the group with HT (26.00% vs. 17.71%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.030) and significantly less likely to be found incidentally during a health check-up in this group (22.93% vs. 59.43%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among 365 patients with complete echocardiography data, left ventricular mass index (86.58\u2009\u00b1\u200926.70 vs. 75.80\u2009\u00b1\u200917.26,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and relative wall thickness (0.43\u2009\u00b1\u20090. 08 vs. 0.41\u2009\u00b1\u20090.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012) were significantly higher in patients with PPGL and a history of HT. The proportions with left ventricular hypertrophy (LVH) (19.40% vs. 8.25%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011) and LVR (53.73% vs. 39.18%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) were also higher when there was a history of HT. After adjusting for age, gender, body mass index, alcohol consumption, smoking status, diabetes, stroke, creatinine level, tumor location, and tumor size, a history of HT was significantly correlated with LVH (odds ratio 2.71, 95% confidence interval 1.18\u20136.19;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018) and LVR (odds ratio 1.83, 95% confidence interval 1.11\u20133.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HT is common in patients with PPGL (70.74% in this cohort). PPGL without a history of HT is more likely to be found incidentally (59.43% in our cohort). HT is associated with LVR in PPGL patients with complete echocardiography data. These patients should be observed carefully for cardiac damage, especially those with a history of HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-024-03936-6","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T02:02:37Z","timestamp":1719367357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypertension and cardiac damage in pheochromocytoma and paraganglioma patients: a large-scale single-center cohort study"],"prefix":"10.1186","volume":"24","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"1","key":"3936_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12872-021-02013-6","volume":"21","author":"J Zhou","year":"2021","unstructured":"Zhou J, Xuan H, Miao Y, Hu J, Dai Y. Acute cardiac complications and subclinical myocardial injuries associated with pheochromocytoma and paraganglioma. BMC Cardiovasc Disord. 2021;21(1):203.","journal-title":"BMC Cardiovasc Disord"},{"key":"3936_CR2","doi-asserted-by":"crossref","unstructured":"Falhammar SYH. H. Cardiovascular manifestations and complications of pheochromocytomas and paragangliomas. J Clin Med. 2020;9(8).","DOI":"10.3390\/jcm9082435"},{"issue":"5","key":"3936_CR3","doi-asserted-by":"publisher","first-page":"e2251","DOI":"10.1210\/clinem\/dgaa965","volume":"106","author":"A Ebbehoj","year":"2021","unstructured":"Ebbehoj A, Stochholm K, Jacobsen SF, Trolle C, Jepsen P, Robaczyk MG, Rasmussen \u00c5K, Feldt-Rasmussen U, Thomsen RW, S\u00f8ndergaard E, Poulsen PL. Incidence and clinical presentation of pheochromocytoma and sympathetic paraganglioma: a population-based study. J Clin Endocrinol Metab. 2021;106(5):e2251\u201361.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"3936_CR4","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1016\/j.jcmg.2020.07.017","volume":"13","author":"P Dobrowolski","year":"2020","unstructured":"Dobrowolski P, Januszewicz A, Klisiewicz A, Gosk-Przyby\u0142ek M, P\u0119czkowska M, Kabat M, Kwapiszewska A, Warcho\u0142-Celi\u0144ska E, Ambroziak U, Doroszko A, Toutounchi S, Ga\u0142\u0105zka Z, Bednarczuk T, G\u00f3rnicka B, Januszewicz M, Hoffman P, Lenders JWM, Eisenhofer G, Prejbisz A. Left ventricular structural and functional alterations in patients with pheochromocytoma\/paraganglioma before and after surgery. JACC Cardiovasc Imaging. 2020;13(12):2498\u2013509.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"3936_CR5","first-page":"1208","volume":"102","author":"B Majtan","year":"2017","unstructured":"Majtan B, Zelinka T, Rosa J, Petr\u00e1k O, Kr\u00e1tk\u00e1 Z, \u0160trauch B, Tuka V, Vr\u00e1nkov\u00e1 A, Michalsk\u00fd D, Nov\u00e1k K, Wichterle D, Widimsk\u00fd J Jr. Long-term effect of adrenalectomy on cardiovascular remodeling in patients with pheochromocytoma. J Clin Endocrinol Metab. 2017;102(4):1208\u201317.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3936_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","volume":"28","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiogr. 2015;28(1):1\u2013e3914.","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"3936_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1530\/EC-17-0321","volume":"7","author":"H Falhammar","year":"2018","unstructured":"Falhammar H, Kjellman M, Calissendorff J. Initial clinical presentation and spectrum of pheochromocytoma: a study of 94 cases from a single center. Endocr Connect. 2018;7(1):186\u201392.","journal-title":"Endocr Connect"},{"key":"3936_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2147\/CLEP.S163065","volume":"10","author":"A Ebbehoj","year":"2018","unstructured":"Ebbehoj A, Jacobsen SF, Trolle C, Robaczyk MG, Rasmussen \u00c5K, Feldt-Rasmussen U, Thomsen RW, Poulsen PL, Stochholm K, S\u00f8ndergaard E. pheochromocytoma in Denmark during 1977\u20132016: validating diagnosis codes and creating a national cohort using patterns of health registrations. Clin Epidemiol. 2018;10:683\u201395.","journal-title":"Clin Epidemiol"},{"issue":"2","key":"3936_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1530\/EJE-09-0384","volume":"161","author":"R Kopetschke","year":"2009","unstructured":"Kopetschke R, Slisko M, Kilisli A, Tuschy U, Wallaschofski H, Fassnacht M, Ventz M, Beuschlein F, Reincke M, Reisch N, Quinkler M. Frequent incidental discovery of phaeochromocytoma: data from a German cohort of 201 phaeochromocytoma. Eur J Endocrinol. 2009;161(2):355\u201361.","journal-title":"Eur J Endocrinol"},{"key":"3936_CR10","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez A, Ravassa S, L\u00f3pez B, Moreno MU, Beaumont J, San Jos\u00e9 G, Querejeta R, Bay\u00e9s-Gen\u00eds A, D\u00edez J. Myocardial remodeling in hypertension. Hypertension. 2018;72(3):549\u201358.","DOI":"10.1161\/HYPERTENSIONAHA.118.11125"},{"issue":"10","key":"3936_CR11","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1530\/ERC-20-0137","volume":"27","author":"A Elenkova","year":"2020","unstructured":"Elenkova A, Shabani R, Kinova E, Vasilev V, Goudev A, Zacharieva S. Global longitudinal strain as a marker for systolic function in patients with pheochromocytomas. Endocr Relat Cancer. 2020;27(10):561\u201370.","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"3936_CR12","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3390\/cancers11030318","volume":"11","author":"J Kvasni\u010dka","year":"2019","unstructured":"Kvasni\u010dka J, Zelinka T, Petr\u00e1k O, Rosa J, \u0160trauch B, Kr\u00e1tk\u00e1 Z, Indra T, Markvartov\u00e1 A, Widimsk\u00fd J Jr. Holaj R. catecholamines induce left ventricular subclinical systolic dysfunction: a speckle-tracking Echocardiography Study. Cancers (Basel). 2019;11(3):318.","journal-title":"Cancers (Basel)"},{"issue":"1\u20132","key":"3936_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cccn.2004.01.027","volume":"345","author":"A Kuch-Wocial","year":"2004","unstructured":"Kuch-Wocial A, Slubowska K, Kostrubiec M, Pasierski T, Januszewicz W, Switalska H, Wocial B, Pruszczyk P. Plasma neuropeptide Y immunoreactivity influences left ventricular mass in pheochromocytoma. Clin Chim Acta. 2004;345(1\u20132):43\u20137.","journal-title":"Clin Chim Acta"},{"issue":"11","key":"3936_CR14","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1210\/jc.2018-02644","volume":"104","author":"O Petr\u00e1k","year":"2019","unstructured":"Petr\u00e1k O, Rosa J, Holaj R, \u0160trauch B, Kr\u00e1tk\u00e1 Z, Kvasni\u010dka J, Kl\u00edmov\u00e1 J, Waldauf P, Hamplov\u00e1 B, Markvartov\u00e1 A, Nov\u00e1k K, Michalsk\u00fd D, Widimsk\u00fd J, Zelinka T. Blood pressure profile, catecholamine phenotype, and target organ damage in pheochromocytoma\/paraganglioma. J Clin Endocrinol Metab. 2019;104(11):5170\u201380.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3936_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/echo.13752","volume":"35","author":"L Ding","year":"2018","unstructured":"Ding L, Zhu WL, Zeng ZP, Li HZ, Ji J, Fang LG, Sun JP. Subclinical left ventricular systolic dysfunction detected by two-dimensional speckle tracking echocardiography in patients with pheochromocytoma and paraganglioma and preserved ejection fraction. Echocardiography. 2018;35(2):184\u201389.","journal-title":"Echocardiography"},{"issue":"5","key":"3936_CR16","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.3892\/ol.2015.3660","volume":"10","author":"W Hu","year":"2015","unstructured":"Hu W, Shi L, Zhou PH, Zhang XB. Plasma concentrations of adrenomedullin and atrial and brain natriuretic peptides in patients with adrenal pheochromocytoma. Oncol Lett. 2015;10(5):3163\u201370.","journal-title":"Oncol Lett"},{"issue":"4","key":"3936_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1530\/EJE-20-1452","volume":"185","author":"AMA Berends","year":"2021","unstructured":"Berends AMA, Buitenwerf E, Riphagen IJ, Lenders JWM, Timmers HJLM, Kruijff S, Links TP, van der Horst-Schrivers ANA, Stegeman CA, Eekhoff EMW, Feelders RA, Corssmit EPM, Groote Veldman R, Haak HR, Muller Kobold AC, Kerstens MN. Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection: a cross-sectional study. Eur J Endocrinol. 2021;185(4):507\u201314.","journal-title":"Eur J Endocrinol"},{"issue":"50","key":"3936_CR18","doi-asserted-by":"publisher","first-page":"e2198","DOI":"10.1097\/MD.0000000000002198","volume":"94","author":"M Batisse-Lignier","year":"2015","unstructured":"Batisse-Lignier M, Pereira B, Motreff P, Pierrard R, Burnot C, Vorilhon C, Maqdasy S, Roche B, Desbiez F, Clerfond G, Citron B, Lusson JR, Tauveron I, Eschalier R. Acute and chronic pheochromocytoma-induced cardiomyopathies: different prognoses? A systematic analytical review. Med (Baltim). 2015;94(50):e2198.","journal-title":"Med (Baltim)"},{"issue":"12","key":"3936_CR19","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1530\/EC-21-0462","volume":"10","author":"J Kvasni\u010dka","year":"2021","unstructured":"Kvasni\u010dka J, Petr\u00e1k O, Zelinka T, Kl\u00edmov\u00e1 J, Kolo\u0161ov\u00e1 B, Nov\u00e1k K, Michalsk\u00fd D, Widimsk\u00fd J, Holaj R. Effect of adrenalectomy on remission of subclinical left ventricular dysfunction in patients with pheochromocytoma: a speckle-tracking echocardiography study. Endocr Connect. 2021;10(12):1538\u201349.","journal-title":"Endocr Connect"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03936-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-03936-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03936-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T02:06:15Z","timestamp":1719367575000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-03936-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3936"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-03936-6","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"12 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Peking University First Hospital Ethics Committee and conducted in accordance with the Declaration of Helsinki. The requirement for written informed consent was waived in view of the retrospective nature of the research by Peking University First Hospital Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors have and declare that: (i) no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work; and (ii) there are no other relationships or activities that could appear to have influenced the submitted work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"325"}}