{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:30:18Z","timestamp":1790609418622,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Zhejiang Province Medical Science and Technology Project","doi-asserted-by":"crossref","award":["2020KY485 and 2021KY089"],"award-info":[{"award-number":["2020KY485 and 2021KY089"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Zhejiang Province Medical Science and Technology Project","doi-asserted-by":"crossref","award":["2020KY485 and 2021KY089"],"award-info":[{"award-number":["2020KY485 and 2021KY089"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Zhejiang Province Medical Science and Technology Project","doi-asserted-by":"crossref","award":["2020KY485 and 2021KY089"],"award-info":[{"award-number":["2020KY485 and 2021KY089"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Zhejiang Province Medical Science and Technology Project","doi-asserted-by":"crossref","award":["2020KY485 and 2021KY089"],"award-info":[{"award-number":["2020KY485 and 2021KY089"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017594","name":"Zhejiang Province Medical Science and Technology Project","doi-asserted-by":"crossref","award":["2020KY485 and 2021KY089"],"award-info":[{"award-number":["2020KY485 and 2021KY089"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Plan","award":["2023ZL021 and 2023ZL302"],"award-info":[{"award-number":["2023ZL021 and 2023ZL302"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Plan","award":["2023ZL021 and 2023ZL302"],"award-info":[{"award-number":["2023ZL021 and 2023ZL302"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Plan","award":["2023ZL021 and 2023ZL302"],"award-info":[{"award-number":["2023ZL021 and 2023ZL302"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Plan","award":["2023ZL021 and 2023ZL302"],"award-info":[{"award-number":["2023ZL021 and 2023ZL302"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Plan","award":["2023ZL021 and 2023ZL302"],"award-info":[{"award-number":["2023ZL021 and 2023ZL302"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Radiotherapy is a primary local treatment for tumors, yet it may lead to complications such as radiation-induced heart disease (RIHD). Currently, there is no standardized approach for preventing RIHD. Dexmedetomidine (Dex) is reported to have cardio-protection effects, while its role in radiation-induced myocardial injury is unknown. In the current study, we aimed to evaluate the radioprotective effect of dexmedetomidine in X-ray radiation-treated mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>18 male mice were randomized into 3 groups: control, 16\u00a0Gy, and 16\u00a0Gy\u2009+\u2009Dex. The 16\u00a0Gy group received a single dose of 16\u00a0Gy X-ray radiation. The 16\u00a0Gy\u2009+\u2009Dex group was pretreated with dexmedetomidine (30\u00a0\u00b5g\/kg, intraperitoneal injection) 30\u00a0min before X-ray radiation. The control group was treated with saline and did not receive X-ray radiation. Myocardial tissues were collected 16 weeks after X-ray radiation. Hematoxylin-eosin staining was performed for histopathological examination. Terminal deoxynucleotidyl transferase dUTP nick-end labeling staining was performed to assess the state of apoptotic cells. Immunohistochemistry staining was performed to examine the expression of CD34 molecule and von Willebrand factor. Besides, western blot assay was employed for the detection of apoptosis-related proteins (BCL2 apoptosis regulator and BCL2-associated X) as well as autophagy-related proteins (microtubule-associated protein 1 light chain 3, beclin 1, and sequestosome 1).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The findings demonstrated that 16\u00a0Gy X-ray radiation resulted in significant changes in myocardial tissues, increased myocardial apoptosis, and activated autophagy. Pretreatment with dexmedetomidine significantly protects mice against 16\u00a0Gy X-ray radiation-induced myocardial injury by inhibiting apoptosis and autophagy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In summary, our study confirmed the radioprotective effect of dexmedetomidine in mitigating cardiomyocyte apoptosis and autophagy induced by 16\u00a0Gy X-ray radiation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-024-03988-8","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T03:39:59Z","timestamp":1719373199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dexmedetomidine ameliorates x-ray-induced myocardial injury via alleviating cardiomyocyte apoptosis and autophagy"],"prefix":"10.1186","volume":"24","author":[{"given":"Runze","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"9","key":"3988_CR1","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/stem.3391","volume":"39","author":"M Ruckert","year":"2021","unstructured":"Ruckert M, Flohr AS, Hecht M, Gaipl US. Radiotherapy and the immune system: more than just immune suppression. Stem Cells. 2021;39(9):1155\u201365.","journal-title":"Stem Cells"},{"issue":"2","key":"3988_CR2","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jtho.2020.11.002","volume":"16","author":"K Banfill","year":"2021","unstructured":"Banfill K, Giuliani M, Aznar M, Franks K, McWilliam A, Schmitt M, Sun F, Vozenin MC. Faivre Finn C, committee IART: Cardiac Toxicity of thoracic radiotherapy: existing evidence and future directions. J Thorac Oncol. 2021;16(2):216\u201327.","journal-title":"J Thorac Oncol"},{"issue":"3","key":"3988_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1136\/hrt.2008.149088","volume":"95","author":"PA Heidenreich","year":"2009","unstructured":"Heidenreich PA, Kapoor JR. Radiation induced heart disease: systemic disorders in heart disease. Heart. 2009;95(3):252\u20138.","journal-title":"Heart"},{"key":"3988_CR4","doi-asserted-by":"crossref","unstructured":"Ping Z, Peng Y, Lang H, Xinyong C, Zhiyi Z, Xiaocheng W, Hong Z, Liang S. Oxidative Stress in Radiation-Induced Cardiotoxicity. Oxid Med Cell Longev 2020, 2020:3579143.","DOI":"10.1155\/2020\/3579143"},{"key":"3988_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0002-9343(63)90039-1","volume":"34","author":"E Rubin","year":"1963","unstructured":"Rubin E, Camara J, Grayzel DM, Zak FG. Radiation-induced cardiac fibrosis. Am J Med. 1963;34:71\u20135.","journal-title":"Am J Med"},{"key":"3988_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.radonc.2020.08.007","volume":"152","author":"E Laugaard Lorenzen","year":"2020","unstructured":"Laugaard Lorenzen E, Christian Rehammar J, Jensen MB, Ewertz M, Brink C. Radiation-induced risk of ischemic heart disease following breast cancer radiotherapy in Denmark, 1977\u20132005. Radiother Oncol. 2020;152:103\u201310.","journal-title":"Radiother Oncol"},{"issue":"4","key":"3988_CR7","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00392-021-01809-y","volume":"110","author":"M Sarkozy","year":"2021","unstructured":"Sarkozy M, Varga Z, Gaspar R, Szucs G, Kovacs MG, Kovacs ZZA, Dux L, Kahan Z, Csont T. Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside. Clin Res Cardiol. 2021;110(4):507\u201331.","journal-title":"Clin Res Cardiol"},{"issue":"5","key":"3988_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/jrr\/rrw064","volume":"57","author":"S Tapio","year":"2016","unstructured":"Tapio S. Pathology and biology of radiation-induced cardiac disease. J Radiat Res. 2016;57(5):439\u201348.","journal-title":"J Radiat Res"},{"key":"3988_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fonc.2015.00039","volume":"5","author":"NK Taunk","year":"2015","unstructured":"Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5:39.","journal-title":"Front Oncol"},{"issue":"10","key":"3988_CR10","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1139\/cjpp-2017-0121","volume":"95","author":"J Slezak","year":"2017","unstructured":"Slezak J, Kura B, Babal P, Barancik M, Ferko M, Frimmel K, Kalocayova B, Kukreja RC, Lazou A, Mezesova L, et al. Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury. Can J Physiol Pharmacol. 2017;95(10):1190\u2013203.","journal-title":"Can J Physiol Pharmacol"},{"issue":"4","key":"3988_CR11","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728\u201341.","journal-title":"Cell"},{"key":"3988_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/978-981-15-4272-5_25","volume":"1207","author":"L Gao","year":"2020","unstructured":"Gao L, Zheng H, Cai Q, Wei L. Autophagy and Tumour Radiotherapy. Adv Exp Med Biol. 2020;1207:375\u201387.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"3988_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s10020-021-00271-w","volume":"27","author":"HY Chen","year":"2021","unstructured":"Chen HY, Xiao ZZ, Ling X, Xu RN, Zhu P, Zheng SY. ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia\/reperfusion injury by regulating autophagy. Mol Med. 2021;27(1):14.","journal-title":"Mol Med"},{"issue":"10","key":"3988_CR14","doi-asserted-by":"publisher","first-page":"13535","DOI":"10.18632\/aging.202786","volume":"13","author":"T Li","year":"2021","unstructured":"Li T, Chen Y, Li Y, Yao Z, Liu W. FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice. Aging. 2021;13(10):13535\u201347.","journal-title":"Aging"},{"issue":"8","key":"3988_CR15","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","volume":"56","author":"MAS Weerink","year":"2017","unstructured":"Weerink MAS, Struys M, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical pharmacokinetics and pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet. 2017;56(8):893\u2013913.","journal-title":"Clin Pharmacokinet"},{"issue":"2","key":"3988_CR16","first-page":"673","volume":"27","author":"E Dil","year":"2023","unstructured":"Dil E, Tumkaya L, Mercantepe T, Rakici S, Yilmaz A, Celik Samanci T, Yazici ZA. Radioprotective effects of dexmedetomidine on x-ray-induced testicular damage. Eur Rev Med Pharmacol Sci. 2023;27(2):673\u201380.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"3988_CR17","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00411-022-00964-8","volume":"61","author":"G Safak","year":"2022","unstructured":"Safak G, Celiker M, Tumkaya L, Mercantepe T, Rakici S, Cinar S, Yilmaz A, Terzi S, Demir E, Celebi Erdivanli O, et al. Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiat Environ Biophys. 2022;61(2):241\u201353.","journal-title":"Radiat Environ Biophys"},{"issue":"5","key":"3988_CR18","doi-asserted-by":"publisher","first-page":"13300","DOI":"10.1080\/21655979.2022.2080420","volume":"13","author":"C Liu","year":"2022","unstructured":"Liu C, Xu R. Dexmedetomidine protects H9C2 rat cardiomyocytes against hypoxia\/reoxygenation injury by regulating the long non-coding RNA colon cancer-associated transcript 1\/microRNA-8063\/Wnt\/beta-catenin axis. Bioengineered. 2022;13(5):13300\u201311.","journal-title":"Bioengineered"},{"issue":"4","key":"3988_CR19","doi-asserted-by":"publisher","first-page":"9369","DOI":"10.1080\/21655979.2022.2054762","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang L, Wang S, Jia T, Sun X, Xing Z, Liu H, Yao J, Chen Y. Dexmedetomidine prevents cardiomyocytes from hypoxia\/reoxygenation injury via modulating tetmethylcytosine dioxygenase 1-mediated DNA demethylation of Sirtuin1. Bioengineered. 2022;13(4):9369\u201386.","journal-title":"Bioengineered"},{"issue":"3","key":"3988_CR20","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s13577-022-00682-9","volume":"35","author":"P Yu","year":"2022","unstructured":"Yu P, Zhang J, Ding Y, Chen D, Sun H, Yuan F, Li S, Li X, Yang P, Fu L, et al. Dexmedetomidine post-conditioning alleviates myocardial ischemia-reperfusion injury in rats by ferroptosis inhibition via SLC7A11\/GPX4 axis activation. Hum Cell. 2022;35(3):836\u201348.","journal-title":"Hum Cell"},{"key":"3988_CR21","doi-asserted-by":"publisher","first-page":"965661","DOI":"10.3389\/fphar.2022.965661","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Zhou H, Zhang H, Sui Y, Zhang Z, Zou Y, Li K, Zhao Y, Xie J, Zhang L. The neuroprotective effect of dexmedetomidine and its mechanism. Front Pharmacol. 2022;13:965661.","journal-title":"Front Pharmacol"},{"key":"3988_CR22","doi-asserted-by":"publisher","first-page":"658677","DOI":"10.3389\/fphar.2021.658677","volume":"12","author":"Q Yu","year":"2021","unstructured":"Yu Q, Zou L, Yuan X, Fang F, Xu F. Dexmedetomidine protects against Septic Liver Injury by enhancing Autophagy through activation of the AMPK\/SIRT1 Signaling Pathway. Front Pharmacol. 2021;12:658677.","journal-title":"Front Pharmacol"},{"issue":"7","key":"3988_CR23","first-page":"922","volume":"50","author":"F Tianxiao","year":"2015","unstructured":"Tianxiao F, Juying Z, Yang J. Establishment of irradiation induced heart injury in C57 mice model and identification of serum marker. Acta Universitatis Medicinalis Anhui. 2015;50(7):922\u2013924925.","journal-title":"Acta Universitatis Medicinalis Anhui"},{"issue":"3","key":"3988_CR24","doi-asserted-by":"publisher","first-page":"226","DOI":"10.7150\/ijms.7897","volume":"11","author":"Y Jang","year":"2014","unstructured":"Jang Y, Yeom MY, Kang ES, Kang JW, Song HK. The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice. Int J Med Sci. 2014;11(3):226\u201333.","journal-title":"Int J Med Sci"},{"key":"3988_CR25","doi-asserted-by":"publisher","first-page":"646265","DOI":"10.3389\/fphar.2021.646265","volume":"12","author":"L Zhang","year":"2021","unstructured":"Zhang L, Xiao F, Zhang J, Wang X, Ying J, Wei G, Chen S, Huang X, Yu W, Liu X, et al. Dexmedetomidine mitigated NLRP3-Mediated Neuroinflammation via the ubiquitin-autophagy pathway to improve Perioperative Neurocognitive Disorder in mice. Front Pharmacol. 2021;12:646265.","journal-title":"Front Pharmacol"},{"issue":"2","key":"3988_CR26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.yexmp.2017.02.005","volume":"102","author":"J Rakocevic","year":"2017","unstructured":"Rakocevic J, Orlic D, Mitrovic-Ajtic O, Tomasevic M, Dobric M, Zlatic N, Milasinovic D, Stankovic G, Ostojic M, Labudovic-Borovic M. Endothelial cell markers from clinician\u2019s perspective. Exp Mol Pathol. 2017;102(2):303\u201313.","journal-title":"Exp Mol Pathol"},{"issue":"2","key":"3988_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.radonc.2011.10.011","volume":"103","author":"I Seemann","year":"2012","unstructured":"Seemann I, Gabriels K, Visser NL, Hoving S, te Poele JA, Pol JF, Gijbels MJ, Janssen BJ, van Leeuwen FW, Daemen MJ, et al. Irradiation induced modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature. Radiother Oncol. 2012;103(2):143\u201350.","journal-title":"Radiother Oncol"},{"issue":"2","key":"3988_CR28","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00066-004-1138-0","volume":"180","author":"M Boerma","year":"2004","unstructured":"Boerma M, Kruse JJ, van Loenen M, Klein HR, Bart CI, Zurcher C, Wondergem J. Increased deposition of Von Willebrand factor in the rat heart after local ionizing irradiation. Strahlenther Onkol. 2004;180(2):109\u201316.","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"3988_CR29","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s11658-022-00335-7","volume":"27","author":"S Zhao","year":"2022","unstructured":"Zhao S, Wu W, Lin X, Shen M, Yang Z, Yu S, Luo Y. Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy. Cell Mol Biol Lett. 2022;27(1):34.","journal-title":"Cell Mol Biol Lett"},{"issue":"42","key":"3988_CR30","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1667\/RR14864.1","volume":"188","author":"S Puukila","year":"2017","unstructured":"Puukila S, Lemon JA, Lees SJ, Tai TC, Boreham DR, Khaper N. Impact of Ionizing Radiation on the Cardiovascular System: a review. Radiat Res. 2017;188(42):539\u201346.","journal-title":"Radiat Res"},{"issue":"12","key":"3988_CR31","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.jacc.2009.11.053","volume":"55","author":"NL Weintraub","year":"2010","unstructured":"Weintraub NL, Jones WK, Manka D. Understanding radiation-induced vascular disease. J Am Coll Cardiol. 2010;55(12):1237\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"3988_CR32","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.radonc.2009.05.021","volume":"92","author":"NS Russell","year":"2009","unstructured":"Russell NS, Hoving S, Heeneman S, Hage JJ, Woerdeman LA, de Bree R, Lohuis PJ, Smeele L, Cleutjens J, Valenkamp A, et al. Novel insights into pathological changes in muscular arteries of radiotherapy patients. Radiother Oncol. 2009;92(3):477\u201383.","journal-title":"Radiother Oncol"},{"issue":"3","key":"3988_CR33","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.ijrobp.2004.07.708","volume":"61","author":"ZA Carr","year":"2005","unstructured":"Carr ZA, Land CE, Kleinerman RA, Weinstock RW, Stovall M, Griem ML, Mabuchi K. Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys. 2005;61(3):842\u201350.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3988_CR34","doi-asserted-by":"publisher","first-page":"317659","DOI":"10.4061\/2011\/317659","volume":"2011","author":"SW Yusuf","year":"2011","unstructured":"Yusuf SW, Sami S, Daher IN. Radiation-induced heart disease: a clinical update. Cardiol Res Pract. 2011;2011:317659.","journal-title":"Cardiol Res Pract"},{"issue":"2","key":"3988_CR35","doi-asserted-by":"publisher","first-page":"H392","DOI":"10.1152\/ajpheart.00124.2017","volume":"313","author":"H Saiki","year":"2017","unstructured":"Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever TD, Classic KL, Pham L, Chen HH, Burnett JC, Russell SJ, et al. Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2017;313(2):H392\u2013407.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3988_CR36","doi-asserted-by":"crossref","unstructured":"Radu P, Zurzu M, Paic V, Bratucu M, Garofil D, Tigora A, Georgescu V, Prunoiu V, Pasnicu C, Popa F et al. CD34-Structure, functions and relationship with Cancer Stem cells. Med (Kaunas) 2023, 59(5).","DOI":"10.3390\/medicina59050938"},{"issue":"Suppl 2","key":"3988_CR37","first-page":"s3","volume":"9","author":"F Peyvandi","year":"2011","unstructured":"Peyvandi F, Garagiola I, Baronciani L. Role of Von Willebrand factor in the haemostasis. Blood Transfus. 2011;9(Suppl 2):s3\u20138.","journal-title":"Blood Transfus"},{"issue":"3","key":"3988_CR38","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12265-012-9422-3","volume":"6","author":"O Muller","year":"2013","unstructured":"Muller O, Bartunek J, Hamilos M, Berza CT, Mangiacapra F, Ntalianis A, Vercruysse K, Duby C, Wijns W, De Bruyne B, et al. Von Willebrand factor inhibition improves endothelial function in patients with stable angina. J Cardiovasc Transl Res. 2013;6(3):364\u201370.","journal-title":"J Cardiovasc Transl Res"},{"issue":"16","key":"3988_CR39","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1002\/pmic.201100178","volume":"11","author":"O Azimzadeh","year":"2011","unstructured":"Azimzadeh O, Scherthan H, Sarioglu H, Barjaktarovic Z, Conrad M, Vogt A, Calzada-Wack J, Neff F, Aubele M, Buske C, et al. Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics. 2011;11(16):3299\u2013311.","journal-title":"Proteomics"},{"key":"3988_CR40","doi-asserted-by":"crossref","unstructured":"Vona R, Gambardella L, Cittadini C, Straface E, Pietraforte D. Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases. Oxid Med Cell Longev 2019, 2019:8267234.","DOI":"10.1155\/2019\/8267234"},{"issue":"6","key":"3988_CR41","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/09553002.2020.1739773","volume":"96","author":"S Johnson","year":"2020","unstructured":"Johnson S, Shaikh SB, Muneesa F, Rashmi B, Bhandary YP. Radiation induced apoptosis and pulmonary fibrosis: curcumin an effective intervention? Int J Radiat Biol. 2020;96(6):709\u201317.","journal-title":"Int J Radiat Biol"},{"issue":"10","key":"3988_CR42","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.7150\/ijbs.35460","volume":"15","author":"H Wang","year":"2019","unstructured":"Wang H, Wei J, Zheng Q, Meng L, Xin Y, Yin X, Jiang X. Radiation-induced heart disease: a review of classification, mechanism and prevention. Int J Biol Sci. 2019;15(10):2128\u201338.","journal-title":"Int J Biol Sci"},{"issue":"1","key":"3988_CR43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbrc.2017.06.190","volume":"500","author":"F Edlich","year":"2018","unstructured":"Edlich F. BCL-2 proteins and apoptosis: recent insights and unknowns. Biochem Biophys Res Commun. 2018;500(1):26\u201334.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3988_CR44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1667\/RR13452.1","volume":"181","author":"V Sridharan","year":"2014","unstructured":"Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry PM, Nowak G, Hauer-Jensen M, Boerma M. Radiation-induced alterations in mitochondria of the rat heart. Radiat Res. 2014;181(3):324\u201334.","journal-title":"Radiat Res"},{"key":"3988_CR45","doi-asserted-by":"publisher","first-page":"111350","DOI":"10.1016\/j.mce.2021.111350","volume":"536","author":"T Huang","year":"2021","unstructured":"Huang T, Cai M, Chen C, Ling C, Zhang B, Zheng W, Luo L. LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p\/HOXB8 pathway. Mol Cell Endocrinol. 2021;536:111350.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"3988_CR46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00395-022-00930-x","volume":"117","author":"Y Xing","year":"2022","unstructured":"Xing Y, Sui Z, Liu Y, Wang MM, Wei X, Lu Q, Wang X, Liu N, Lu C, Chen R, et al. Blunting TRPML1 channels protects myocardial ischemia\/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022;117(1):20.","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"3988_CR47","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/path.3025","volume":"226","author":"S Sridhar","year":"2012","unstructured":"Sridhar S, Botbol Y, Macian F, Cuervo AM. Autophagy and disease: always two sides to a problem. J Pathol. 2012;226(2):255\u201373.","journal-title":"J Pathol"},{"issue":"10","key":"3988_CR48","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s40265-015-0419-5","volume":"75","author":"GM Keating","year":"2015","unstructured":"Keating GM. Dexmedetomidine: a review of its use for Sedation in the Intensive Care setting. Drugs. 2015;75(10):1119\u201330.","journal-title":"Drugs"},{"issue":"1","key":"3988_CR49","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3892\/mmr.2020.11114","volume":"22","author":"C Wang","year":"2020","unstructured":"Wang C, Yuan W, Hu A, Lin J, Xia Z, Yang CF, Li Y, Zhang Z. Dexmedetomidine alleviated sepsis\u2013induced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22(1):175\u201384.","journal-title":"Mol Med Rep"},{"key":"3988_CR50","doi-asserted-by":"publisher","first-page":"118004","DOI":"10.1016\/j.lfs.2020.118004","volume":"257","author":"C Tang","year":"2020","unstructured":"Tang C, Hu Y, Gao J, Jiang J, Shi S, Wang J, Geng Q, Liang X, Chai X. Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat. Life Sci. 2020;257:118004.","journal-title":"Life Sci"},{"key":"3988_CR51","doi-asserted-by":"crossref","unstructured":"Wu ZL, Davis JRJ, Zhu Y. Dexmedetomidine Protects against Myocardial Ischemia\/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway. Biomed Res Int 2020, 2020:8979270.","DOI":"10.1155\/2020\/8979270"},{"key":"3988_CR52","doi-asserted-by":"publisher","first-page":"1043956","DOI":"10.3389\/fphar.2023.1043956","volume":"14","author":"H Kong","year":"2023","unstructured":"Kong H, Li M, Deng CM, Wu YJ, He ST, Mu DL. A comprehensive overview of clinical research on dexmedetomidine in the past 2 decades: a bibliometric analysis. Front Pharmacol. 2023;14:1043956.","journal-title":"Front Pharmacol"},{"issue":"3","key":"3988_CR53","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10735-023-10120-1","volume":"54","author":"J Li","year":"2023","unstructured":"Li J, Wang K, Liu M, He J, Zhang H, Liu H. Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K\/Akt\/mTOR pathway. J Mol Histol. 2023;54(3):173\u201381.","journal-title":"J Mol Histol"},{"key":"3988_CR54","doi-asserted-by":"crossref","unstructured":"Feng X, Ma W, Zhu J, Jiao W, Wang Y. Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS\/Nrf2 signaling pathway. Mol Med Rep 2021, 24(3).","DOI":"10.3892\/mmr.2021.12300"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03988-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-03988-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-03988-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:03:08Z","timestamp":1719374588000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-03988-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3988"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-03988-8","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The design and development of animal experiments involved in this study were conducted according to the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and approved by the Institutional Animal Care and Use Committee of Zhejiang Cancer Hospital Research Ethics Committee (approval no. zjzlsd-2020-07-017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"323"}}