{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:05:01Z","timestamp":1751562301978},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and aims<\/jats:title>\n                <jats:p>H-type hypertension is essential hypertension combined with high homocysteine, and both synergistically increase the risk of cardiovascular and cerebrovascular events. The aim of this study was to investigate the risk factors of H-type hypertension in Tibetan plateau population and correlation with MTHFR C677T gene.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>A multi-stage cluster random sampling method was used to select the research subjects in Tibet Autonomous Region from June 2020 to November 2021. Among Tibetans, the incidence of H-type hypertension accounted for 84.31% of hypertensive patients. The logistic regression analysis demonstrated that age, uric acid (UA), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were risk factors for the prevalence of H-type hypertension, the OR (95% CI) was 1.083(1.073\u20131.094), 1.002(1.001\u20131.004), 1.240(1.050\u20131.464) and 2.274(1.432\u20133.611), respectively. MTHFR C677T TT genotype patients with H-type hypertension OR (95% CI) was 1.629(1.004\u20132.643). Based on this, a nomogram model was established, and the reliability of the model was proved by area under ROC curve, Brier score and average absolute error. The model\u2019s results indicate that for every five years of age, the score increases by 6 points; for a 2mmol\/L increase in TG, the score increases by 5.5 points; for a 1mmol\/L increase in LDL-C, the score increases by 10 points; and individuals with the TT genotype receive 8 points. The higher the score, the greater the risk of disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The MTHFR C677T TT genotype is a risk locus for Tibetan patients with H-type hypertension, with age, TG, and LDL-C were identified as risk factors for the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-024-04015-6","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T07:02:10Z","timestamp":1720422130000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China"],"prefix":"10.1186","volume":"24","author":[{"given":"Jiaojiao","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"4015_CR1","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.19723\/j.issn.1671-167X.2022.05.033","volume":"54","author":"Z Liang","year":"2022","unstructured":"Liang Z, Fan FF, Zhang Y, Qin XH, Li JP, Huo Y. [Rate and characteristics of H-type hypertension in Chinese hypertensive population and comparison with American population]. Beijing Da Xue Xue Bao. 2022;54:1028\u201337. https:\/\/doi.org\/10.19723\/j.issn.1671-167X.2022.05.033.","journal-title":"Beijing Da Xue Xue Bao"},{"key":"4015_CR2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/ijms20010231","volume":"20","author":"R Moretti","year":"2019","unstructured":"Moretti R, Caruso P. The controversial role of Homocysteine in Neurology: from labs to clinical practice. Int J Mol Sci. 2019;20:231. https:\/\/doi.org\/10.3390\/ijms20010231.","journal-title":"Int J Mol Sci"},{"key":"4015_CR3","doi-asserted-by":"publisher","first-page":"e1001177","DOI":"10.1371\/journal.pmed.1001177","volume":"9","author":"R Clarke","year":"2012","unstructured":"Clarke R, Bennett DA, Parish S, Verhoef P, D\u00f6tsch-Klerk M, Lathrop M, et al. 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All participants gave informed consent to participate in the study. Participants gave their consent by signing or fingerprinting the informed consent form after receiving information about the content of the project. All participants volunteered to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Role of the funder\/sponsor"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"345"}}