{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:26:12Z","timestamp":1791721572472,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070476"],"award-info":[{"award-number":["82070476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joint Funds for the innovation of science and Technology, Fujian province","award":["2019Y9057"],"award-info":[{"award-number":["2019Y9057"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-024-04120-6","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T03:44:04Z","timestamp":1724989444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["SIRT5 induces autophagy and alleviates myocardial infarction via desuccinylation of TOM1"],"prefix":"10.1186","volume":"24","author":[{"given":"Zengliang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"issue":"1","key":"4120_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/2048872613502283","volume":"3","author":"ES Ketchum","year":"2014","unstructured":"Ketchum ES, et al. The Seattle Post myocardial infarction model (SPIM): prediction of mortality after acute myocardial infarction with left ventricular dysfunction. Eur Heart J Acute Cardiovasc Care. 2014;3(1):46\u201355.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"10191","key":"4120_CR2","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/S0140-6736(19)31419-9","volume":"393","author":"R Barnett","year":"2019","unstructured":"Barnett R. Acute myocardial infarction. Lancet. 2019;393(10191):2580.","journal-title":"Lancet"},{"key":"4120_CR3","doi-asserted-by":"crossref","unstructured":"De Villiers C, Riley PR. Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion. Dis Model Mech. 2020;13(11).","DOI":"10.1242\/dmm.046565"},{"issue":"10151","key":"4120_CR4","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S0140-6736(18)31996-2","volume":"392","author":"S Blankenberg","year":"2018","unstructured":"Blankenberg S, Neumann JT, Westermann D. Diagnosing myocardial infarction: a highly sensitive issue. Lancet. 2018;392(10151):893\u20134.","journal-title":"Lancet"},{"issue":"10052","key":"4120_CR5","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(16)31739-1","volume":"388","author":"K Isaaz","year":"2016","unstructured":"Isaaz K, Gerbay A. Deferred stenting in acute ST elevation myocardial infarction. Lancet. 2016;388(10052):1371.","journal-title":"Lancet"},{"issue":"5","key":"4120_CR6","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nm1574","volume":"13","author":"A Nakai","year":"2007","unstructured":"Nakai A, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13(5):619\u201324.","journal-title":"Nat Med"},{"issue":"10","key":"4120_CR7","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1073\/pnas.1015081108","volume":"108","author":"DJ Cao","year":"2011","unstructured":"Cao DJ, et al. Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A. 2011;108(10):4123\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4120_CR8","doi-asserted-by":"publisher","first-page":"p8602041","DOI":"10.1155\/2018\/8602041","volume":"2018","author":"R Ghosh","year":"2018","unstructured":"Ghosh R, Pattison JS. Macroautophagy and chaperone-mediated autophagy in Heart failure: the known and the unknown. Oxid Med Cell Longev. 2018;2018:p8602041.","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"4120_CR9","first-page":"4827","volume":"15","author":"H Fu","year":"2018","unstructured":"Fu H, Li X, Tan J. NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia\/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. Oncol Lett. 2018;15(4):4827\u201336.","journal-title":"Oncol Lett"},{"issue":"1","key":"4120_CR10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nchembio.495","volume":"7","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, et al. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol. 2011;7(1):58\u201363.","journal-title":"Nat Chem Biol"},{"issue":"11","key":"4120_CR11","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1016\/j.molcel.2021.04.002","volume":"81","author":"Y Tong","year":"2021","unstructured":"Tong Y, et al. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Mol Cell. 2021;81(11):2303\u2013e23168.","journal-title":"Mol Cell"},{"issue":"22","key":"4120_CR12","doi-asserted-by":"publisher","first-page":"5702","DOI":"10.1111\/jcmm.17507","volume":"26","author":"W Bai","year":"2022","unstructured":"Bai W, et al. Protein succinylation associated with the progress of hepatocellular carcinoma. J Cell Mol Med. 2022;26(22):5702\u201312.","journal-title":"J Cell Mol Med"},{"issue":"4","key":"4120_CR13","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4103\/1673-5374.382229","volume":"19","author":"J Lian","year":"2024","unstructured":"Lian J, et al. Succinylation modification: a potential therapeutic target in stroke. Neural Regen Res. 2024;19(4):781\u20137.","journal-title":"Neural Regen Res"},{"issue":"1","key":"4120_CR14","doi-asserted-by":"publisher","first-page":"2271196","DOI":"10.1080\/10641963.2023.2271196","volume":"45","author":"Y Wang","year":"2023","unstructured":"Wang Y, et al. MG53 alleviates hypoxia\/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification. Clin Exp Hypertens. 2023;45(1):2271196.","journal-title":"Clin Exp Hypertens"},{"key":"4120_CR15","doi-asserted-by":"publisher","first-page":"172520","DOI":"10.1016\/j.ejphar.2019.172520","volume":"858","author":"L Liu","year":"2019","unstructured":"Liu L, et al. Exogenous nicotinamide adenine dinucleotide administration alleviates ischemia\/reperfusion-induced oxidative injury in isolated rat hearts via Sirt5-SDH-succinate pathway. Eur J Pharmacol. 2019;858:172520.","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"4120_CR16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.molcel.2013.06.001","volume":"50","author":"J Park","year":"2013","unstructured":"Park J, et al. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013;50(6):919\u201330.","journal-title":"Mol Cell"},{"issue":"4","key":"4120_CR17","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.molcel.2019.03.021","volume":"74","author":"G Wang","year":"2019","unstructured":"Wang G, et al. Regulation of UCP1 and mitochondrial metabolism in Brown Adipose tissue by reversible succinylation. Mol Cell. 2019;74(4):844\u2013e8577.","journal-title":"Mol Cell"},{"issue":"2","key":"4120_CR18","doi-asserted-by":"publisher","first-page":"585","DOI":"10.7150\/ijbs.83306","volume":"20","author":"C Wei","year":"2024","unstructured":"Wei C, et al. SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. Int J Biol Sci. 2024;20(2):585\u2013605.","journal-title":"Int J Biol Sci"},{"key":"4120_CR19","doi-asserted-by":"publisher","first-page":"p5876841","DOI":"10.1155\/2021\/5876841","volume":"2021","author":"X Chang","year":"2021","unstructured":"Chang X, et al. SIRT5-Related desuccinylation modification contributes to Quercetin-Induced Protection against Heart failure and high-glucose-prompted cardiomyocytes injured through regulation of mitochondrial quality surveillance. Oxid Med Cell Longev. 2021;2021:p5876841.","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"4120_CR20","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1007\/s10495-015-1122-4","volume":"20","author":"L Yu","year":"2015","unstructured":"Yu L, et al. Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1\/Hes1-PTEN\/Akt signaling. Apoptosis. 2015;20(6):796\u2013810.","journal-title":"Apoptosis"},{"issue":"16","key":"4120_CR21","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1073\/pnas.1519858113","volume":"113","author":"S Sadhukhan","year":"2016","unstructured":"Sadhukhan S, et al. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A. 2016;113(16):4320\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"4120_CR22","first-page":"e38","volume":"133","author":"D Mozaffarian","year":"2016","unstructured":"Mozaffarian D, et al. Heart Disease and Stroke Statistics-2016 update: a Report from the American Heart Association. Circulation. 2016;133(4):e38\u2013360.","journal-title":"Circulation"},{"issue":"11","key":"4120_CR23","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1089\/ars.2010.3479","volume":"14","author":"Y Aviv","year":"2011","unstructured":"Aviv Y, et al. Regulation of autophagy in the heart: you only live twice. Antioxid Redox Signal. 2011;14(11):2245\u201350.","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"4120_CR24","doi-asserted-by":"publisher","first-page":"e2577","DOI":"10.1038\/cddis.2017.7","volume":"8","author":"Y Zheng","year":"2017","unstructured":"Zheng Y, et al. Berbamine postconditioning protects the heart from ischemia\/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017;8(2):e2577.","journal-title":"Cell Death Dis"},{"issue":"8","key":"4120_CR25","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","volume":"32","author":"H Ma","year":"2011","unstructured":"Ma H, et al. Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J. 2011;32(8):1025\u201338.","journal-title":"Eur Heart J"},{"issue":"2","key":"4120_CR26","doi-asserted-by":"publisher","first-page":"113319","DOI":"10.1016\/j.yexcr.2022.113319","volume":"419","author":"D Zheng","year":"2022","unstructured":"Zheng D, et al. SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression. Exp Cell Res. 2022;419(2):113319.","journal-title":"Exp Cell Res"},{"issue":"48","key":"4120_CR27","doi-asserted-by":"publisher","first-page":"19767","DOI":"10.1074\/jbc.M117.809897","volume":"292","author":"KA Hershberger","year":"2017","unstructured":"Hershberger KA, et al. Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. J Biol Chem. 2017;292(48):19767\u201381.","journal-title":"J Biol Chem"},{"key":"4120_CR28","doi-asserted-by":"crossref","unstructured":"Chen XF et al. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018;19(5).","DOI":"10.15252\/embr.201745124"},{"issue":"1","key":"4120_CR29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/s12276-023-00928-y","volume":"55","author":"J Mao","year":"2023","unstructured":"Mao J, et al. SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Exp Mol Med. 2023;55(1):253\u201368.","journal-title":"Exp Mol Med"},{"issue":"6","key":"4120_CR30","doi-asserted-by":"publisher","first-page":"811","DOI":"10.15252\/embr.201541643","volume":"17","author":"L Zhou","year":"2016","unstructured":"Zhou L, et al. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016;17(6):811\u201322.","journal-title":"EMBO Rep"},{"issue":"1","key":"4120_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbrc.2013.10.033","volume":"441","author":"ZF Lin","year":"2013","unstructured":"Lin ZF, et al. SIRT5 desuccinylates and activates SOD1 to eliminate ROS. Biochem Biophys Res Commun. 2013;441(1):191\u20135.","journal-title":"Biochem Biophys Res Commun"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-04120-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-04120-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-04120-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T03:44:52Z","timestamp":1724989492000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-04120-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4120"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-04120-6","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"11 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Animal Care and Use Committee of Nanjing Medical University (2023-12-13; IACUC-2312031). All experiments were performed in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors approved the final manuscript and the submission to this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"464"}}