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All procedures conformed to internationally accepted guidelines and ethics for animal research. All authors confirm that all methods are reported in accordance with ARRIVE guidelines for the reporting of animal experiments. Great efforts were made to reduce the total number of animals used and to minimize their suffering.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"531"}}