{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:20:09Z","timestamp":1760347209817,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1411500","22ZR1411500"],"award-info":[{"award-number":["22ZR1411500","22ZR1411500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Provincial Natural Science Foundation of China","award":["2023J011693"],"award-info":[{"award-number":["2023J011693"]}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk01701"],"award-info":[{"award-number":["shslczdzk01701"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-024-04261-8","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T09:12:00Z","timestamp":1730193120000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blocking NaV1.8 regulates atrial fibrillation inducibility and cardiac conduction after myocardial infarction"],"prefix":"10.1186","volume":"24","author":[{"given":"Baozhen","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonglei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"4261_CR1","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1093\/eurheartj\/ehn579","volume":"30","author":"J Schmitt","year":"2009","unstructured":"Schmitt J, Duray G, Gersh BJ, Hohnloser SH. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30:1038\u201345.","journal-title":"Eur Heart J"},{"key":"4261_CR2","doi-asserted-by":"publisher","first-page":"e021417","DOI":"10.1161\/JAHA.121.021417","volume":"10","author":"Y Obayashi","year":"2021","unstructured":"Obayashi Y, Shiomi H, Morimoto T, et al. Newly diagnosed Atrial Fibrillation in Acute myocardial infarction. J Am Heart Assoc. 2021;10:e021417.","journal-title":"J Am Heart Assoc"},{"key":"4261_CR3","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s00392-021-01805-2","volume":"110","author":"L Fauchier","year":"2021","unstructured":"Fauchier L, Bisson A, Bodin A, et al. Outcomes in patients with acute myocardial infarction and new atrial fibrillation: a nationwide analysis. Clin Res Cardiol. 2021;110:1431\u20138.","journal-title":"Clin Res Cardiol"},{"key":"4261_CR4","doi-asserted-by":"publisher","first-page":"e86715","DOI":"10.1172\/jci.insight.86715","volume":"17","author":"M Vaseghi","year":"2017","unstructured":"Vaseghi M, Salavatian S, Rajendran PS, et al. Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction. JCI Insight. 2017;17:2: e86715.","journal-title":"JCI Insight"},{"key":"4261_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jacc.2007.02.066","volume":"50","author":"Y Hou","year":"2007","unstructured":"Hou Y, Scherlag BJ, Lin J, et al. Ganglionated plexi modulate extrinsic cardiac autonomic nerve input: effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation. J Am Coll Cardiol. 2007;50:61\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"4261_CR6","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1016\/j.jacc.2013.06.053","volume":"62","author":"DG Katritsis","year":"2013","unstructured":"Katritsis DG, Pokushalov E, Romanov A, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2013;62:2318\u201325.","journal-title":"J Am Coll Cardiol"},{"key":"4261_CR7","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1126\/science.1156916","volume":"321","author":"B Abrahamsen","year":"2008","unstructured":"Abrahamsen B, Zhao J, Asante CO, et al. The cell and molecular basis of mechanical, cold and inflammatory pain. Science. 2008;321:702\u20135.","journal-title":"Science"},{"key":"4261_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1536\/ihj.52.146","volume":"52","author":"P Facer","year":"2011","unstructured":"Facer P, Punjabi PP, Abrari A, et al. Localisation of SCN10A gene product na(v)1.8 and novel painrelated ion channels in human heart. Int Heart J. 2011;52:146\u201352.","journal-title":"Int Heart J"},{"key":"4261_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1161\/CIRCRESAHA.112.274035","volume":"111","author":"AO Verkerk","year":"2012","unstructured":"Verkerk AO, Remme CA, Schumacher CA, et al. Functional NaV1.8 channels in intracardiac neurons: the link between SCN10A and cardiac Electrophysiology. Circ Res. 2012;111:333\u201343.","journal-title":"Circ Res"},{"key":"4261_CR10","doi-asserted-by":"publisher","first-page":"e004050","DOI":"10.1161\/JAHA.116.004050","volume":"5","author":"X Chen","year":"2016","unstructured":"Chen X, Yu L, Shi S, et al. Neuronal NaV1.8 channels as a novel therapeutic target of acute atrial fibrillation prevention. J Am Heart Assoc. 2016;5:e004050.","journal-title":"J Am Heart Assoc"},{"key":"4261_CR11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s10557-019-06925-6","volume":"33","author":"S Casini","year":"2019","unstructured":"Casini S, Marchal GA, Kawasaki M, et al. Absence of functional Nav1.8 channels in non-diseased atrial and ventricular cardiomyocytes. Cardiovasc Drugs Ther. 2019;33:649\u201360.","journal-title":"Cardiovasc Drugs Ther"},{"key":"4261_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1161\/CIRCULATIONAHA.121.054083","volume":"144","author":"JCK Man","year":"2021","unstructured":"Man JCK, Bosada FM, Scholman KT, et al. Variant intronic enhancer controls SCN10A-short expression and heart conduction. Circulation. 2021;144:229\u201342.","journal-title":"Circulation"},{"key":"4261_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/ng.516","volume":"42","author":"JC Chambers","year":"2010","unstructured":"Chambers JC, Zhao J, Terracciano CM, et al. Genetic variation in SCN10A influences cardiac conduction. Nat Genet. 2010;42:149\u201352.","journal-title":"Nat Genet"},{"key":"4261_CR14","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/europace\/eut278","volume":"16","author":"JT Delaney","year":"2014","unstructured":"Delaney JT, Muhammad R, Shi Y, et al. Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation. Europace. 2014;16:485\u201390.","journal-title":"Europace"},{"key":"4261_CR15","doi-asserted-by":"publisher","first-page":"708279","DOI":"10.3389\/fcvm.2021.708279","volume":"8","author":"B Qi","year":"2021","unstructured":"Qi B, Dai S, Song Y, et al. Blockade of NaV1.8 increases the susceptibility to ventricular arrhythmias during Acute myocardial infarction. Fron Cardiovasc Med. 2021;8:708279.","journal-title":"Fron Cardiovasc Med"},{"key":"4261_CR16","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1093\/cvr\/cvy152","volume":"114","author":"N Dybkova","year":"2018","unstructured":"Dybkova N, Ahmad S, Pabel S, et al. Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart. Cardiovasc Res. 2018;114:1728\u201337.","journal-title":"Cardiovasc Res"},{"key":"4261_CR17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/ehf2.12378","volume":"6","author":"S Ahmad","year":"2019","unstructured":"Ahmad S, Tirilomis P, Pabel S, et al. The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy. ESC Heart Fail. 2019;6:154\u201363.","journal-title":"ESC Heart Fail"},{"key":"4261_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.yjmcc.2020.05.002","volume":"144","author":"P Bengel","year":"2020","unstructured":"Bengel P, Ahmad S, Tirilomis P, et al. Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia. J Mol Cell Cardiol. 2020;144:35\u201346.","journal-title":"J Mol Cell Cardiol"},{"key":"4261_CR19","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.1038\/s41467-021-26690-1","volume":"15","author":"P Bengel","year":"2021","unstructured":"Bengel P, Dybkova N, Tirilomis P, et al. Detrimental proarrhythmogenic interaction of Ca2+\/calmodulin-dependent protein kinase II and NaV1.8 in heart failure. Nat Commun. 2021;15:12:6586.","journal-title":"Nat Commun"},{"key":"4261_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/CIRCGENETICS.111.961631","volume":"5","author":"J Hsu","year":"2012","unstructured":"Hsu J, Hanna P, Van Wagoner DR, et al. Whole genome expression differences in human left and right atria ascertained by RNA sequencing. Circ Cardiovasc Genet. 2012;5:327\u201335.","journal-title":"Circ Cardiovasc Genet"},{"key":"4261_CR21","doi-asserted-by":"publisher","first-page":"e0131432","DOI":"10.1371\/journal.pone.0131432","volume":"10","author":"C Poulet","year":"2015","unstructured":"Poulet C, Wettwer E, Grunnet M, et al. Late sodium current in human atrial cardiomyocytes from patients in sinus rhythm and atrial fibrillation. PLoS ONE. 2015;10:e0131432.","journal-title":"PLoS ONE"},{"key":"4261_CR22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cjca.2022.12.023","volume":"39","author":"S Casini","year":"2023","unstructured":"Casini S, Marchal GA, Kawasaki M, et al. Differential Sodium current remodelling identifies distinct Cellular Proarrhythmic mechanisms in Paroxysmal vs Persistent Atrial Fibrillation. Can J Cardiol. 2023;39:277\u201388.","journal-title":"Can J Cardiol"},{"key":"4261_CR23","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/cvr\/cvu005","volume":"102","author":"B Qi","year":"2014","unstructured":"Qi B, Wei Y, Chen S, et al. NaV1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility. Cardiovas Res. 2014;102:480\u20136.","journal-title":"Cardiovas Res"},{"key":"4261_CR24","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1540-8167.2010.01908.x","volume":"22","author":"L Yu","year":"2011","unstructured":"Yu L, Scherlag BJ, Li S, et al. Low-level vagosympathetic nerve stimulation inhibits atrial fibrillation inducibility: direct evidence by neural recordings from intrinsic cardiac ganglia. J Cardiovasc Electrophysiol. 2011;22:455\u201363.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"4261_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00395-020-0780-8","volume":"115","author":"S Pabel","year":"2020","unstructured":"Pabel S, Ahmad S, Tirilomis P, et al. Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice. Basic Res Cardiol. 2020;115:20.","journal-title":"Basic Res Cardiol"},{"key":"4261_CR26","doi-asserted-by":"publisher","first-page":"a034173","DOI":"10.1101\/cshperspect.a034173","volume":"10","author":"MJ Capilupi","year":"2020","unstructured":"Capilupi MJ, Kerath SM, Becker LB. Vagus nerve stimulation and the Cardiovascular System. Cold Spring Harb Perspect Med. 2020;10:a034173.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4261_CR27","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.hrthm.2018.03.012","volume":"15","author":"N Yamaguchi","year":"2018","unstructured":"Yamaguchi N, Yamakawa K, Rajendran PS, Takamiya T, Vaseghi M. Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction. Heart Rhythm. 2018;15:1214\u201322.","journal-title":"Heart Rhythm"},{"key":"4261_CR28","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1161\/01.CIR.0000080327.32573.7C","volume":"22","author":"Y Miyauchi","year":"2003","unstructured":"Miyauchi Y, Zhou S, Okuyama Y, et al. Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation. Circulation. 2003;22:108:360\u20136.","journal-title":"Circulation"},{"key":"4261_CR29","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ccep.2016.01.007","volume":"8","author":"TT Tomson","year":"2016","unstructured":"Tomson TT, Arora R. Modulation of cardiac potassium current by neural tone and ischemia. Card Electrophysiol Clin. 2016;8:349\u201360.","journal-title":"Card Electrophysiol Clin"},{"key":"4261_CR30","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1113\/JP271165","volume":"594","author":"PS Rajendran","year":"2016","unstructured":"Rajendran PS, Nakamura K, Ajijola OA, et al. Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. J Physiol. 2016;594:321\u201341.","journal-title":"J Physiol"},{"key":"4261_CR31","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.neuroscience.2009.09.001","volume":"164","author":"DB Hoover","year":"2009","unstructured":"Hoover DB, Isaacs ER, Jacques F, Hoard JL, Pag\u00e9 P, Armour JA. Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia. Neuroscience. 2009;164:1170\u20139.","journal-title":"Neuroscience"},{"key":"4261_CR32","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/cvr\/cvv042","volume":"106","author":"ER Behr","year":"2015","unstructured":"Behr ER, Savio-Galimberti E, Barc J, et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015;106:520\u20139.","journal-title":"Cardiovasc Res"},{"key":"4261_CR33","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/europace\/euv078","volume":"18","author":"M Fukuyama","year":"2015","unstructured":"Fukuyama M, Ohno S, Makiyama T, Horie M. Novel SCN10A variants associated with Brugada syndrome. Europace. 2015;18:905\u201311.","journal-title":"Europace"},{"key":"4261_CR34","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1073\/pnas.0611364104","volume":"104","author":"MF Jarvis","year":"2007","unstructured":"Jarvis MF, Honore P, Shieh CC, et al. A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci USA. 2007;104:8520\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4261_CR35","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1124\/jpet.107.134148","volume":"324","author":"S McGaraughty","year":"2008","unstructured":"McGaraughty S, Chu KL, Scanio MJ, Kort ME, Faltynek CR, Jarvis MF. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)- furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. J Pharmacol Exp Ther. 2008;324:1204\u201311.","journal-title":"J Pharmacol Exp Ther"},{"key":"4261_CR36","doi-asserted-by":"publisher","first-page":"19413","DOI":"10.1073\/pnas.1117020108","volume":"108","author":"AL Blasiusa","year":"2011","unstructured":"Blasiusa AL, Dubinb AE, Petrusc MJ, et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci USA. 2011;108:19413\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4261_CR37","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3389\/fphar.2020.01163","volume":"11","author":"B Liu","year":"2020","unstructured":"Liu B, Li N, Zhang J, et al. The role of Voltage-gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: evidence from a Retrospective Clinical Study and Mouse Model. Front Pharmacol. 2020;11:1163.","journal-title":"Front Pharmacol"},{"key":"4261_CR38","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1113\/jphysiol.2007.138461","volume":"583","author":"KE Brack","year":"2007","unstructured":"Brack KE, Patel VH, Coote JH, Ng GA. Nitric oxide mediates the vagal protective effect on ventricular fibrillation via effects on action potential duration restitution in the rabbit heart. J Physiol. 2007;583:695\u2013704.","journal-title":"J Physiol"},{"key":"4261_CR39","first-page":"1967","volume":"19","author":"G Giannopoulos","year":"2017","unstructured":"Giannopoulos G, Kossyvakis C, Angelidis C, et al. Coincidental ganglionated plexus modification during radiofrequency pulmonary vein isolation and post-ablation arrhythmia recurrence. Europace. 2017;19:1967\u201372.","journal-title":"Europace"},{"key":"4261_CR40","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/europace\/euq416","volume":"13","author":"E Mikhaylov","year":"2011","unstructured":"Mikhaylov E, Kanidieva A, Sviridova N, et al. Outcome of anatomic ganglionated plexi ablation to treat paroxysmal atrial fibrillation: a 3-year follow-up study. Europace. 2011;13:362\u201370.","journal-title":"Europace"},{"key":"4261_CR41","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.hrthm.2013.01.030","volume":"10","author":"LW Lo","year":"2013","unstructured":"Lo LW, Scherlag BJ, Chang HY, Lin YJ, Chen SA, Po SS. Paradoxical long-term proarrhythmic efects after ablating the head station ganglionated plexi of the vagal innervation to the heart. Heart Rhythm. 2013;10:751\u20137.","journal-title":"Heart Rhythm"},{"key":"4261_CR42","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1161\/CIRCEP.113.000799","volume":"7","author":"J Mao","year":"2014","unstructured":"Mao J, Yin X, Zhang Y, et al. Ablation of epicardial ganglionated plexi increases atrial vulnerability to arrhythmias in dogs. Circ Arrhythm Electrophysiol. 2014;7:711\u20137.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"4261_CR43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ijcard.2012.09.067","volume":"168","author":"B He","year":"2013","unstructured":"He B, Lu Z, He W, et al. Efects of ganglionated plexi ablation on ventricular electrophysiological properties in normal hearts and after acute myocardial ischemia. Int J Cardiol. 2013;168:86\u201393.","journal-title":"Int J Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-04261-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-024-04261-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-024-04261-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T10:05:49Z","timestamp":1730196349000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-024-04261-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4261"],"URL":"https:\/\/doi.org\/10.1186\/s12872-024-04261-8","relation":{},"ISSN":["1471-2261"],"issn-type":[{"type":"electronic","value":"1471-2261"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal handling and experimental procedures were approved by Zhongshan Hospital Institutional Animal Care and Use Committee <b><u>(No. 2022286)<\/u><\/b> in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"605"}}