{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:40:15Z","timestamp":1739770815065,"version":"3.37.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Excessive prolongation of the PR interval indicates the potential for atrioventricular (AV) asynchrony, resulting in severe impairment of cardiac function.<\/jats:p>\n            <jats:p>Case presentation.<\/jats:p>\n            <jats:p>A 72-year-old man presented to the cardiology department with a history of worsening shortness of breath and chest tightness over the past 3\u00a0years. The electrocardiogram (ECG) showed sinus rhythm with a prolonged PR interval of 400\u00a0ms. The echocardiogram revealed mild mitral valve regurgitation with mitral E-A fusion during ventricular diastole. The patient received left bundle branch area pacing to shorten the AV conduction time.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In patients with symptomatic AV block, reflected by an excessively prolonged PR interval, prompt decision-making regarding cardiac pacing therapy can help relieve clinical symptoms and enhance the patient's quality of life.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12872-025-04512-2","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:09:00Z","timestamp":1739768940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excessively prolonged PR interval in a patient with worsening shortness of breath: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Yanjuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"issue":"4","key":"4512_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ccep.2021.06.007","volume":"13","author":"LR Jackson 2nd","year":"2021","unstructured":"Jackson LR 2nd, Ugowe F. Epidemiology and Outcomes Associated with PR Prolongation. Card Electrophysiol Clin. 2021;13(4):661\u20139. https:\/\/doi.org\/10.1016\/j.ccep.2021.06.007.","journal-title":"Card Electrophysiol Clin"},{"issue":"4","key":"4512_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","volume":"29","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277\u2013314. https:\/\/doi.org\/10.1016\/j.echo.2016.01.011.","journal-title":"J Am Soc Echocardiogr"},{"issue":"2","key":"4512_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/eurheartj\/eht176","volume":"35","author":"AL Aro","year":"2014","unstructured":"Aro AL, Anttonen O, Kerola T, et al. Prognostic significance of prolonged PR interval in the general population. Eur Heart J. 2014;35(2):123\u20139. https:\/\/doi.org\/10.1093\/eurheartj\/eht176.","journal-title":"Eur Heart J"},{"key":"4512_CR4","doi-asserted-by":"publisher","unstructured":"Cheng S: Long-term Outcomes in Individuals With Prolonged PR Interval or First-Degree Atrioventricular Block. Jama 2009, 301(24). https:\/\/doi.org\/10.1001\/jama.2009.888","DOI":"10.1001\/jama.2009.888"},{"issue":"15","key":"4512_CR5","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1093\/eurheartj\/ehr139","volume":"32","author":"RK Crisel","year":"2011","unstructured":"Crisel RK, Farzaneh-Far R, Na B, et al. First-degree atrioventricular block is associated with heart failure and death in persons with stable coronary artery disease: data from the Heart and Soul Study. Eur Heart J. 2011;32(15):1875\u201380. https:\/\/doi.org\/10.1093\/eurheartj\/ehr139.","journal-title":"Eur Heart J"},{"issue":"2","key":"4512_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10840-006-9065-x","volume":"17","author":"SS Barold","year":"2007","unstructured":"Barold SS, Ilercil A, Leonelli F, et al. First-degree atrioventricular block. J Interv Card Electrophysiol. 2007;17(2):139\u201352. https:\/\/doi.org\/10.1007\/s10840-006-9065-x.","journal-title":"J Interv Card Electrophysiol"},{"issue":"14","key":"4512_CR7","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIR.0b013e3182618569","volume":"126","author":"CM Tracy","year":"2012","unstructured":"Tracy CM, Epstein AE, Darbar D, et al. 2012 ACCF\/AHA\/HRS Focused Update of the 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities. Circulation. 2012;126(14):1784\u2013800. https:\/\/doi.org\/10.1161\/CIR.0b013e3182618569.","journal-title":"Circulation"},{"issue":"5","key":"4512_CR8","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1540-8159.1996.tb03355.x","volume":"19","author":"SS Barold","year":"1996","unstructured":"Barold SS. Indications for permanent cardiac pacing in first-degree AV block: class I, II, or III? Pacing Clin Electrophysiol. 1996;19(5):747\u201351. https:\/\/doi.org\/10.1111\/j.1540-8159.1996.tb03355.x.","journal-title":"Pacing Clin Electrophysiol"},{"issue":"3","key":"4512_CR9","doi-asserted-by":"publisher","first-page":"e283","DOI":"10.1161\/CIR.0b013e318276ce9b","volume":"127","author":"AE Epstein","year":"2013","unstructured":"Epstein AE, DiMarco JP, Ellenbogen KA, et al. 2012 ACCF\/AHA\/HRS focused update incorporated into the ACCF\/AHA\/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation. 2013;127(3):e283-352. https:\/\/doi.org\/10.1161\/CIR.0b013e318276ce9b.","journal-title":"Circulation"},{"issue":"13","key":"4512_CR10","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jacc.2022.07.019","volume":"80","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zhu H, Hou X, et al. Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy. J Am Coll Cardiol. 2022;80(13):1205\u201316. https:\/\/doi.org\/10.1016\/j.jacc.2022.07.019.","journal-title":"J Am Coll Cardiol"},{"issue":"40","key":"4512_CR11","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1093\/eurheartj\/ehac445","volume":"43","author":"M Jastrzebski","year":"2022","unstructured":"Jastrzebski M, Kielbasa G, Cano O, et al. Left bundle branch area pacing outcomes: the multicentre European MELOS study. Eur Heart J. 2022;43(40):4161\u201373. https:\/\/doi.org\/10.1093\/eurheartj\/ehac445.","journal-title":"Eur Heart J"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04512-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-04512-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04512-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:09:02Z","timestamp":1739768942000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-04512-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4512"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-04512-2","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"assertion":[{"value":"8 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the Declaration of Helsinki and approved by the ethics committee of the first affiliated hospital of Nanjing Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"106"}}