{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:40:45Z","timestamp":1741866045356,"version":"3.38.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["81172750","81700372"],"award-info":[{"award-number":["81172750","81700372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"GuangDong\u00a0Basic\u00a0and\u00a0Applied\u00a0Basic\u00a0Research Foundation","doi-asserted-by":"crossref","award":["20 20A1515010301"],"award-info":[{"award-number":["20 20A1515010301"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2020KTSCX034"],"award-info":[{"award-number":["2020KTSCX034"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-04629-4","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:30:14Z","timestamp":1741761014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population"],"prefix":"10.1186","volume":"25","author":[{"given":"Fangqin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"LuLi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"issue":"22","key":"4629_CR1","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","volume":"137","author":"Z Wang","year":"2018","unstructured":"Wang Z, Chen Z, Zhang L, Wang X, Hao G, Zhang Z, Shao L, Tian Y, Dong Y, Zheng C, et al. Status of hypertension in China: results from the China hypertension survey, 2012\u20132015. Circulation. 2018;137(22):2344\u201356.","journal-title":"Circulation"},{"issue":"3","key":"4629_CR2","first-page":"175","volume":"58","author":"MG Butler","year":"2010","unstructured":"Butler MG. Genetics of hypertension. Current status. J Med Liban. 2010;58(3):175\u20138.","journal-title":"J Med Liban"},{"issue":"4","key":"4629_CR3","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.117.07802","volume":"70","author":"TJ Guzik","year":"2017","unstructured":"Guzik TJ, Touyz RM. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017;70(4):660\u20137.","journal-title":"Hypertension"},{"issue":"2","key":"4629_CR4","first-page":"158","volume":"49","author":"A Agita","year":"2017","unstructured":"Agita A, Alsagaff MT. Inflammation, immunity, and hypertension. Acta Med Indones. 2017;49(2):158\u201365.","journal-title":"Acta Med Indones"},{"issue":"4","key":"4629_CR5","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.4049\/jimmunol.179.4.2551","volume":"179","author":"AA Chackerian","year":"2007","unstructured":"Chackerian AA, Oldham ER, Murphy EE, Schmitz J, Pflanz S, Kastelein RA. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007;179(4):2551\u20135.","journal-title":"J Immunol"},{"issue":"37","key":"4629_CR6","doi-asserted-by":"publisher","first-page":"14918","DOI":"10.1073\/pnas.1308651110","volume":"110","author":"X Liu","year":"2013","unstructured":"Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A. 2013;110(37):14918\u201323.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"4629_CR7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cytogfr.2015.07.017","volume":"26","author":"M De la Fuente","year":"2015","unstructured":"De la Fuente M, Macdonald TT, Hermoso MA. The IL-33\/ST2 axis: role in health and disease. Cytokine Growth Factor Rev. 2015;26(6):615\u201323.","journal-title":"Cytokine Growth Factor Rev"},{"key":"4629_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cyto.2019.05.010","volume":"120","author":"M Stankovic","year":"2019","unstructured":"Stankovic M, Ljujic B, Babic S, Maravic-Stojkovic V, Mitrovic S, Arsenijevic N, Radak D, Pejnovic N. Lukic ML.IL-33\/IL-33R in various types of carotid artery atherosclerotic lesions. Cytokine. 2019;120:242\u201350.","journal-title":"Cytokine"},{"key":"4629_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.yjmcc.2019.01.018","volume":"128","author":"JC Garbern","year":"2019","unstructured":"Garbern JC, Williams J, Kristl AC, Malick A, Rachmin I, Gaeta B, Ahmed N, Vujic A, Libby P, Lee RT. Dysregulation of IL-33\/ST2 signaling and myocardial periarteriolar fibrosis. J Mol Cell Cardiol. 2019;128:179\u201386.","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"4629_CR10","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1161\/HYPERTENSIONAHA.118.11157","volume":"72","author":"R Ghali","year":"2018","unstructured":"Ghali R, Altara R, Louch WE, Cataliotti A, Mallat Z, Kaplan A, Zouein FA, Booz GW. IL-33 (Interleukin 33)\/sST2 Axis in hypertension and heart failure. Hypertension. 2018;72(4):818\u201328.","journal-title":"Hypertension"},{"issue":"7","key":"4629_CR11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1097\/HJH.0b013e3283611bdf","volume":"31","author":"JE Ho","year":"2013","unstructured":"Ho JE, Larson MG, Ghorbani A, Cheng S, Vasan RS, Wang TJ, Januzzi JJ. Soluble ST2 predicts elevated SBP in the community. J Hypertens. 2013;31(7):1431\u20136.","journal-title":"J Hypertens"},{"issue":"12","key":"4629_CR12","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1373\/clinchem.2012.192153","volume":"58","author":"EE Coglianese","year":"2012","unstructured":"Coglianese EE, Larson MG, Vasan RS, Ho JE, Ghorbani A, McCabe EL, Cheng S, Fradley MG, Kretschman D, Gao W, et al. Distribution and clinical correlates of the Interleukin receptor family member soluble ST2 in the Framingham heart study. Clin Chem. 2012;58(12):1673\u201381.","journal-title":"Clin Chem"},{"issue":"7","key":"4629_CR13","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/jcmm.13058","volume":"21","author":"F Wu","year":"2017","unstructured":"Wu F, Li L, Wen Q, Yang J, Chen Z, Wu P, He M, Zhang X, Wu T, Cheng L. A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR-202-3p. J Cell Mol Med. 2017;21(7):1292\u20139.","journal-title":"J Cell Mol Med"},{"key":"4629_CR14","doi-asserted-by":"crossref","unstructured":"Li L, Zhong D, Xie Y, Yang X, Yu Z, Zhang D, Jiang X, Wu Y, Wu F. Blood MicroRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2. Biosci Rep. 2020;40(5).","DOI":"10.1042\/BSR20200378"},{"issue":"11","key":"4629_CR15","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1038\/s41440-019-0291-x","volume":"42","author":"X Yin","year":"2019","unstructured":"Yin X, Cao H, Wei Y, Li HH. Alteration of the IL-33-sST2 pathway in hypertensive patients and a mouse model. Hypertens Res. 2019;42(11):1664\u201371.","journal-title":"Hypertens Res"},{"issue":"3","key":"4629_CR16","doi-asserted-by":"publisher","first-page":"e9684","DOI":"10.1371\/journal.pone.0009684","volume":"5","author":"M He","year":"2010","unstructured":"He M, Guo H, Yang X, Zhou L, Zhang X, Cheng L, Zeng H, Hu FB, Tanguay RM, Wu T. Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population. PLoS ONE. 2010;5(3):e9684.","journal-title":"PLoS ONE"},{"issue":"2","key":"4629_CR17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.atherosclerosis.2011.05.040","volume":"218","author":"Y Shi","year":"2011","unstructured":"Shi Y, Zhou L, Huang LH, Lian YT, Zhang XM, Guo H, Wu TC, Cheng LX, He MA. Plasma ferritin levels, genetic variations in HFE gene, and coronary heart disease in Chinese: a case-control study. Atherosclerosis. 2011;218(2):386\u201390.","journal-title":"Atherosclerosis"},{"issue":"6","key":"4629_CR18","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","volume":"25","author":"G Mancia","year":"2007","unstructured":"Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, et al. 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC). J Hypertens. 2007;25(6):1105\u201387.","journal-title":"J Hypertens"},{"issue":"12","key":"4629_CR19","doi-asserted-by":"publisher","first-page":"23227","DOI":"10.3390\/ijms151223227","volume":"15","author":"F Wu","year":"2014","unstructured":"Wu F, He M, Wen Q, Zhang W, Yang J, Zhang X, Wu T, Cheng L. Associations between variants in IL-33\/ST2 signaling pathway genes and coronary heart disease risk. Int J Mol Sci. 2014;15(12):23227\u201339.","journal-title":"Int J Mol Sci"},{"key":"4629_CR20","unstructured":"Gauderman WJ, Morrison JM. December. Quanto 1.1: A computer program for power and sample size calculations for genetic\u2014Epidemiology studies. Available online: http:\/\/hydra.Usc.Edu\/gxe (accessed on 1 2008)."},{"key":"4629_CR21","doi-asserted-by":"publisher","first-page":"9541079","DOI":"10.1155\/2019\/9541079","volume":"2019","author":"SM Ma","year":"2019","unstructured":"Ma SM, Yang JW, Tu JF, Yang NN, Du YZ, Wang XR, Wang L, Huang J, Liu CZ. Gene-Level regulation of acupuncture therapy in spontaneously hypertensive rats: A whole transcriptome analysis. Evid Based Complement Alternat Med. 2019;2019:9541079.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"4629_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/hr.2016.16","volume":"39","author":"I Ates","year":"2016","unstructured":"Ates I, Ozkayar N, Ates H, Karakulak UN, Kursun O, Topcuoglu C, Inan B, Yilmaz N. Elevated Circulating sST2 associated with subclinical atherosclerosis in newly diagnosed primary hypertension. Hypertens Res. 2016;39(7):513\u20138.","journal-title":"Hypertens Res"},{"issue":"4","key":"4629_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000049030","volume":"9","author":"S Laye","year":"2001","unstructured":"Laye S, Liege S, Li KS, Moze E, Neveu PJ. Physiological significance of the Interleukin 1 receptor accessory protein. Neuroimmunomodulat. 2001;9(4):225\u201330.","journal-title":"Neuroimmunomodulat"},{"issue":"1","key":"4629_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11596-015-1382-9","volume":"35","author":"JH Yang","year":"2015","unstructured":"Yang JH, Wu FQ, Wen Q, Zhang WC, Wang YE, Xiong X, Su YW, Cheng LX. Association of IL33\/ST2 signal pathway gene polymorphisms with myocardial infarction in a Chinese Han population. J Huazhong Univ Sci Technolog Med Sci. 2015;35(1):16\u201320.","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"issue":"6","key":"4629_CR25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/hr.2011.233","volume":"35","author":"M Nikpay","year":"2012","unstructured":"Nikpay M, Seda O, Tremblay J, Petrovich M, Gaudet D, Kotchen TA, Cowley AJ, Hamet P. Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse. Hypertens Res. 2012;35(6):585\u201391.","journal-title":"Hypertens Res"},{"key":"4629_CR26","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O\u2019Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683\u2013765.","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"4629_CR27","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41569-023-00964-1","volume":"21","author":"J Tomasz","year":"2024","unstructured":"Tomasz J, Guzik R, Nosalski P, Maffia, Grant R. Drummond.Immune and inflammatory mechanisms in hypertension. Nat Rev Cardiol. 2024;21(6):396\u2013416.","journal-title":"Nat Rev Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04629-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-04629-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04629-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:46:47Z","timestamp":1741862807000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-04629-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4629"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-04629-4","relation":{},"ISSN":["1471-2261"],"issn-type":[{"type":"electronic","value":"1471-2261"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"2 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Tongji Medical College (project identification code: S073; 21 February, 2011) and the ethics committee of the Second Affiliated Hospital of Nanchang University (5 March, 2017). All participants provided written informed consent. All procedures performed in this study involving human participants were in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All methods involved in this study were carried out in accordance with relevant guidelines and regulations. All participants provided their written informed consent in this study. Written informed consent was obtained for the publication of any original images or data included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"172"}}