{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:34:41Z","timestamp":1789835681591,"version":"4.0.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Hypertension is a major public health problem. Despite existing treatment options, overall blood pressure control is still insufficient. Digital health interventions have the potential to improve treatment success. We developed <jats:italic>liebria<\/jats:italic>, an internet-based digital intervention accessible via smartphones and computers, designed to support the self-management of hypertension.\n<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We tested the effectiveness of <jats:italic>liebria<\/jats:italic> in reducing systolic blood pressure and improving other relevant endpoints in adults with hypertension using a parallel randomized controlled trial design. Adults with hypertension (mean age 54.5 years, 47.1% male) were recruited via a German health insurance provider and randomized (1:1; concealed allocation; no blinding of participants) to receive <jats:italic>liebria<\/jats:italic> in addition to treatment as usual (<jats:italic>n<\/jats:italic> = 52), or treatment as usual alone (<jats:italic>n<\/jats:italic>=50). Primary outcome was systolic blood pressure after 3 months (T1). Secondary endpoints were diastolic blood pressure, pulse pressure, quality of life, medication adherence, and social and work-related functioning.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study's statistical power was limited due to a smaller sample size (<jats:italic>N<\/jats:italic> = 102) than the a priori target sample size (<jats:italic>N<\/jats:italic>=676). Intention-to-treat analyses showed an effect of <jats:italic>liebria<\/jats:italic> on systolic blood pressure (baseline-adjusted between-group difference -3.5 mmHg, 95% CI -7.13 to 0.13, <jats:italic>p<\/jats:italic> = .053, Cohen\u2019s <jats:italic>d<\/jats:italic> = 0.36). More participants in the intervention group (78.2% vs. 54.3% in the control group) showed reductions in systolic blood pressure (<jats:italic>p<\/jats:italic> = .076). Moreover, <jats:italic>liebria<\/jats:italic> had effects on social and work-related functioning. No effects emerged for diastolic blood pressure, pulse pressure, quality of life, or medication adherence. No adverse events or device effects were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The present study shows first promising results of <jats:italic>liebria<\/jats:italic>\u2019s effects on systolic blood pressure and social and work-related functioning. Future studies should aim to replicate effects in a larger sample to increase statistical power.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>German Clinical Trials Register (DRKS00025871); <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/en\/trial\/DRKS00025871\" ext-link-type=\"uri\">https:\/\/drks.de\/search\/en\/trial\/DRKS00025871<\/jats:ext-link>\n; date of registration: October 5, 2021.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12872-025-04698-5","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T05:42:17Z","timestamp":1743831737000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Internet-based digital intervention to support the self-management of hypertension compared to usual care: results of the HALCYON randomized controlled trial"],"prefix":"10.1186","volume":"25","author":[{"given":"Bj\u00f6rn","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Riepenhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda T.","family":"Betz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Jauch-Chara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Reshetnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"issue":"10159","key":"4698_CR1","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","author":"JD Stanaway","year":"2018","unstructured":"Stanaway JD, Afshin A, Gakidou E, Lim SS, Abate D, Abate KH, et al. 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