{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:36:59Z","timestamp":1783985819891,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Clinical Medical Research Center for Cardiovascular Diseases","award":["NCRC2020015"],"award-info":[{"award-number":["NCRC2020015"]}]},{"name":"High-Level Hospital Clinical Research Funding","award":["2022-GSP-GG-26"],"award-info":[{"award-number":["2022-GSP-GG-26"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-04748-y","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:57:21Z","timestamp":1744768641000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complex versus non-complex percutaneous coronary intervention in patients with atrial fibrillation: a real-world study"],"prefix":"10.1186","volume":"25","author":[{"given":"Yimeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-shan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyuan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"4748_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ahj.2023.04.004","volume":"263","author":"B Hennessey","year":"2023","unstructured":"Hennessey B, et al. Rationale and design of the dynamic coronary roadmap for contrast reduction (dcr4contrast) in Pci randomized controlled trial[J]. Am Heart J. 2023;263:151\u20138.","journal-title":"Am Heart J"},{"issue":"25","key":"4748_CR2","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1056\/NEJMoa2310610","volume":"389","author":"CA Rajkumar","year":"2023","unstructured":"Rajkumar CA, et al. A placebo-controlled trial of percutaneous coronary intervention for stable angina[J]. N Engl J Med. 2023;389(25):2319\u201330.","journal-title":"N Engl J Med"},{"key":"4748_CR3","doi-asserted-by":"crossref","unstructured":"Gabaldon-Perez A et al. Coronary revascularization and long-term survivorship in chronic coronary syndrome[J]. J Clin Med, 2021;10(4).","DOI":"10.3390\/jcm10040610"},{"key":"4748_CR4","doi-asserted-by":"crossref","unstructured":"Kodeboina M et al. Challenges and burdens in the coronary artery disease care pathway for patients undergoing percutaneous coronary intervention: A contemporary narrative review[J]. Int J Environ Res Public Health, 2023;20(9).","DOI":"10.3390\/ijerph20095633"},{"issue":"7","key":"4748_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00392-022-01994-4","volume":"111","author":"R Hemetsberger","year":"2022","unstructured":"Hemetsberger R, et al. Complex vs. Non-complex percutaneous coronary intervention with newer-generation drug-eluting stents: an analysis from the randomized bioflow trials[J]. Clin Res Cardiol. 2022;111(7):795\u2013805.","journal-title":"Clin Res Cardiol"},{"issue":"7","key":"4748_CR6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.4244\/EIJ-D-20-00361","volume":"16","author":"MO Mohamed","year":"2020","unstructured":"Mohamed MO, et al. Impact of coronary lesion complexity in percutaneous coronary intervention: One-year outcomes from the large, multicentre e-ultimaster registry[J]. EuroIntervention. 2020;16(7):603\u201312.","journal-title":"EuroIntervention"},{"issue":"31","key":"4748_CR7","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1093\/eurheartj\/ehz453","volume":"40","author":"PW Serruys","year":"2019","unstructured":"Serruys PW, et al. Impact of long-term Ticagrelor monotherapy following 1-month dual antiplatelet therapy in patients who underwent complex percutaneous coronary intervention: insights from the global leaders trial[J]. Eur Heart J. 2019;40(31):2595\u2013604.","journal-title":"Eur Heart J"},{"key":"4748_CR8","doi-asserted-by":"crossref","unstructured":"Yoon GS et al. Prognosis of atrial fibrillation patients undergoing Pci according to anticoagulants and antiplatelet agents[J]. J Clin Med, 2021;10(15).","DOI":"10.3390\/jcm10153370"},{"key":"4748_CR9","unstructured":"Gragnano F et al. Antithrombotic therapy optimization in patients with atrial fibrillation undergoing percutaneous coronary intervention[J]. J Clin Med, 2023;13(1)."},{"issue":"38","key":"4748_CR10","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","volume":"44","author":"RA Byrne","year":"2023","unstructured":"Byrne RA, et al. 2023 Esc guidelines for the management of acute coronary syndromes[J]. Eur Heart J. 2023;44(38):3720\u2013826.","journal-title":"Eur Heart J"},{"key":"4748_CR11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ahj.2022.10.006","volume":"255","author":"A Oliva","year":"2023","unstructured":"Oliva A, et al. P2y12 inhibitors monotherapy in patients undergoing complex vs non-complex percutaneous coronary intervention: A meta-analysis of randomized trials[J]. Am Heart J. 2023;255:71\u201381.","journal-title":"Am Heart J"},{"issue":"2","key":"4748_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2459\/JCM.0000000000001399","volume":"24","author":"S De Servi","year":"2023","unstructured":"De Servi S, et al. Tailoring oral antiplatelet therapy in acute coronary syndromes: from guidelines to clinical practice[J]. J Cardiovasc Med (Hagerstown). 2023;24(2):77\u201386.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"36","key":"4748_CR13","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","volume":"45","author":"IC Van Gelder","year":"2024","unstructured":"Van Gelder IC, et al. 2024 Esc guidelines for the management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (eacts)[J]. Eur Heart J. 2024;45(36):3314\u2013414.","journal-title":"Eur Heart J"},{"issue":"4","key":"4748_CR14","first-page":"527","volume":"13","author":"L Manzi","year":"2024","unstructured":"Manzi L, et al. Antiplatelet therapy in patients requiring oral anticoagulation and undergoing percutaneous coronary intervention[J]. Interv Cardiol Clin. 2024;13(4):527\u201341.","journal-title":"Interv Cardiol Clin"},{"issue":"7","key":"4748_CR15","doi-asserted-by":"publisher","first-page":"e010565","DOI":"10.1161\/CIRCINTERVENTIONS.121.010565","volume":"14","author":"JJ Coughlan","year":"2021","unstructured":"Coughlan JJ, et al. Ticagrelor or Prasugrel in patients with acute coronary syndrome undergoing complex percutaneous coronary intervention[J]. Circ Cardiovasc Interv. 2021;14(7):e010565.","journal-title":"Circ Cardiovasc Interv"},{"key":"4748_CR16","doi-asserted-by":"crossref","unstructured":"Teodorovich N et al. The cha(2)ds(2)-vas(c) score predicts mortality in patients undergoing coronary angiography[J]. Life (Basel), 2023;13(10).","DOI":"10.3390\/life13102026"},{"issue":"23","key":"4748_CR17","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","volume":"123","author":"R Mehran","year":"2011","unstructured":"Mehran R, et al. Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the bleeding academic research consortium[J]. Circulation. 2011;123(23):2736\u201347.","journal-title":"Circulation"},{"issue":"23","key":"4748_CR18","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1093\/eurheartj\/ehu063","volume":"35","author":"A Narula","year":"2014","unstructured":"Narula A, et al. Contrast-induced acute kidney injury after primary percutaneous coronary intervention: results from the horizons-ami substudy[J]. Eur Heart J. 2014;35(23):1533\u201340.","journal-title":"Eur Heart J"},{"issue":"23","key":"4748_CR19","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1093\/eurheartj\/ehy223","volume":"39","author":"HM Garcia-Garcia","year":"2018","unstructured":"Garcia-Garcia HM, et al. Standardized end point definitions for coronary intervention trials: the academic research consortium-2 consensus document[J]. Eur Heart J. 2018;39(23):2192\u2013207.","journal-title":"Eur Heart J"},{"issue":"4","key":"4748_CR20","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1001\/jamacardio.2022.0052","volume":"7","author":"D Hwang","year":"2022","unstructured":"Hwang D, et al. Prasugrel dose de-escalation therapy after complex percutaneous coronary intervention in patients with acute coronary syndrome: A post hoc analysis from the host-reduce-polytech-acs trial[J]. JAMA Cardiol. 2022;7(4):418\u201326.","journal-title":"JAMA Cardiol"},{"issue":"10","key":"4748_CR21","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1016\/j.cjca.2022.06.014","volume":"38","author":"A Landi","year":"2022","unstructured":"Landi A, et al. Radial vs femoral access in Acs patients undergoing complex Pci is associated with consistent bleeding benefit and no excess of risks[J]. Can J Cardiol. 2022;38(10):1488\u2013500.","journal-title":"Can J Cardiol"},{"key":"4748_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ijcard.2018.03.103","volume":"268","author":"P Genereux","year":"2018","unstructured":"Genereux P, et al. Impact of percutaneous coronary intervention extent, complexity and platelet reactivity on outcomes after drug-eluting stent implantation[J]. Int J Cardiol. 2018;268:61\u20137.","journal-title":"Int J Cardiol"},{"issue":"1","key":"4748_CR23","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/clinchem\/hvaa281","volume":"67","author":"IA Katrukha","year":"2021","unstructured":"Katrukha IA. Katrukha. Myocardial injury and the release of troponins i and t in the blood of patients[J]. Clin Chem. 2021;67(1):124\u201330.","journal-title":"Clin Chem"},{"issue":"3","key":"4748_CR24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/ehjcvp\/pvac071","volume":"9","author":"J Nicolas","year":"2023","unstructured":"Nicolas J, et al. Efficacy and safety of p2y12 inhibitor monotherapy after complex Pci: A collaborative systematic review and meta-analysis[J]. Eur Heart J Cardiovasc Pharmacother. 2023;9(3):240\u201350.","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"10","key":"4748_CR25","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s12471-021-01606-2","volume":"29","author":"RH Olie","year":"2021","unstructured":"Olie RH, et al. Antithrombotic therapy in high-risk patients after percutaneous coronary intervention; study design, cohort profile and incidence of adverse events[J]. Neth Heart J. 2021;29(10):525\u201335.","journal-title":"Neth Heart J"},{"issue":"6","key":"4748_CR26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1161\/CIRCULATIONAHA.120.050438","volume":"143","author":"DJ Angiolillo","year":"2021","unstructured":"Angiolillo DJ, et al. Antithrombotic therapy in patients with atrial fibrillation treated with oral anticoagulation undergoing percutaneous coronary intervention: A North American perspective: 2021 update[J]. Circulation. 2021;143(6):583\u201396.","journal-title":"Circulation"},{"key":"4748_CR27","doi-asserted-by":"crossref","unstructured":"Suo N et al. Evolving antithrombotic treatment patterns for patients with nonvalvular atrial fibrillation and acute coronary syndrome or underwent percutaneous coronary intervention in China: A cross-sectional study[J]. Front Cardiovasc Med, 2022;9.","DOI":"10.3389\/fcvm.2022.846803"},{"key":"4748_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.amjcard.2023.09.081","volume":"209","author":"A Spirito","year":"2023","unstructured":"Spirito A, et al. Outcomes after complex Pci with combo stent implantation: insights from a real-world pooled dataset[J]. Am J Cardiol. 2023;209:52\u20134.","journal-title":"Am J Cardiol"},{"issue":"3","key":"4748_CR29","first-page":"359","volume":"17","author":"B Lattuca","year":"2024","unstructured":"Lattuca B, et al. Ticagrelor vs clopidogrel for complex percutaneous coronary intervention in chronic coronary syndrome[J]. JACC: Cardiovasc Interventions. 2024;17(3):359\u201370.","journal-title":"JACC: Cardiovasc Interventions"},{"key":"4748_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.017","author":"M Writing Committee","year":"2023","unstructured":"Writing Committee M, et al. 2023 Acc\/aha\/accp\/hrs guideline for the diagnosis and management of atrial fibrillation: A report of the American college of cardiology\/american heart association joint committee on clinical practice guidelines[J]. J Am Coll Cardiol. 2023. https:\/\/doi.org\/10.1016\/j.jacc.2023.08.017","journal-title":"J Am Coll Cardiol"},{"key":"4748_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2023.08.010","author":"SK Chua","year":"2023","unstructured":"Chua SK, et al. Use of the cha(2)ds(2)-vasc score to predict subsequent myocardial infarction in atrial fibrillation[J]. Hellenic J Cardiol. 2023. https:\/\/doi.org\/10.1016\/j.hjc.2023.08.010","journal-title":"Hellenic J Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04748-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-04748-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04748-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:57:30Z","timestamp":1744768650000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-04748-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4748"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-04748-y","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study design and protocol have been approved by the Ethics Committee of Fuwai Hospital (Approved No. 2017\u2009\u2212\u2009923) and conformed to the Declaration of Helsinki. All the patients had signed informed consents to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"285"}}