{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:02:44Z","timestamp":1746504164818,"version":"3.40.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-04793-7","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T11:16:35Z","timestamp":1746443795000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of risk factors for adverse events associated with cardiogenic syncope due to coronary artery disease in the elderly"],"prefix":"10.1186","volume":"25","author":[{"given":"Yangyang","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoying","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiYa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"issue":"22","key":"4793_CR1","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1161\/CIRCULATIONAHA.110.976092","volume":"122","author":"GI Fishman","year":"2010","unstructured":"Fishman GI, Chugh SS, Dimarco JP, et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation. 2010;122(22):2335\u201348.","journal-title":"Circulation"},{"issue":"3","key":"4793_CR2","first-page":"442","volume":"45","author":"HN Wo","year":"2021","unstructured":"Wo HN, Yu SJ, Bai YP, et al. Study on the clinical value of dynamic electrocardiogram in predicting cardiogenic syncope in the elderly. Guizhou Med. 2021;45(3):442\u20133.","journal-title":"Guizhou Med"},{"issue":"1","key":"4793_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.hrthm.2015.08.038","volume":"13","author":"A Adler","year":"2016","unstructured":"Adler A, Rosso R, Chorin E, et al. Risk stratification in Brugada syndrome: clinical characteristics, electrocardiographic parameters, and auxiliary testing. Heart Rhythm. 2016;13(1):299\u2013310.","journal-title":"Heart Rhythm"},{"issue":"12","key":"4793_CR4","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1056\/NEJMoa012407","volume":"347","author":"ES Soteriades","year":"2002","unstructured":"Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. 2002;347(12):878\u201385.","journal-title":"N Engl J Med"},{"issue":"2","key":"4793_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119\u201377. https:\/\/doi.org\/10.1093\/eurheartj\/ehx393.","journal-title":"Eur Heart J."},{"issue":"12","key":"4793_CR6","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1136\/hrt.2008.143123","volume":"94","author":"A Del Rosso","year":"2008","unstructured":"Del Rosso A, Ungar A, Maggi R, et al. Clinical predictors of cardiac syncope at initial evaluation in patients referred urgently to a general hospital: the EGSYS score. Heart. 2008;94(12):1620\u20136.","journal-title":"Heart"},{"issue":"5","key":"4793_CR7","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1016\/j.jacc.2017.03.003","volume":"70","author":"WK Shen","year":"2017","unstructured":"Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2017;70(5):e39\u2013110.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"4793_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/00005792-199005000-00004","volume":"69","author":"WN Kapoor","year":"1990","unstructured":"Kapoor WN. Evaluation and outcome of patients with syncope. Medicine (Baltimore). 1990;69(3):160\u201375.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"4793_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/0735-1097(93)90724-F","volume":"21","author":"HR Middlekauff","year":"1993","unstructured":"Middlekauff HR, Stevenson WG, Stevenson LW, et al. Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope. J Am Coll Cardiol. 1993;21(1):110\u20136.","journal-title":"J Am Coll Cardiol"},{"key":"4793_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.crphys.2021.01.003","volume":"4","author":"Y Liang","year":"2021","unstructured":"Liang Y, Li X, Tse G, et al. Diagnostic value of cardiac troponin I and N-terminal pro-B-Type Natriuretic Peptide in cardiac syncope. Curr Res Physiol. 2021;4:24\u20138.","journal-title":"Curr Res Physiol"},{"issue":"25","key":"4793_CR11","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/eurheartj\/ehu176","volume":"35","author":"HJ Wellens","year":"2014","unstructured":"Wellens HJ, Schwartz PJ, Lindemans FW, et al. Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J. 2014;35(25):1642\u201351.","journal-title":"Eur Heart J"},{"issue":"2","key":"4793_CR12","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jacc.2005.08.067","volume":"47","author":"SM Straus","year":"2006","unstructured":"Straus SM, Kors JA, De Bruin ML, et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006;47(2):362\u20137.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"4793_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.5811\/westjem.2018.2.37100","volume":"19","author":"TA Gibson","year":"2018","unstructured":"Gibson TA, Weiss RE, Sun BC. Predictors of short-term outcomes after syncope: a systematic review and meta-analysis. West J Emerg Med. 2018;19(3):517\u201323.","journal-title":"West J Emerg Med"},{"issue":"4","key":"4793_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/emj.2006.042739","volume":"24","author":"MJ Reed","year":"2007","unstructured":"Reed MJ, Newby DE, Coull AJ, et al. The Risk stratification Of Syncope in the Emergency department (ROSE) pilot study: a comparison of existing syncope guidelines. Emerg Med J. 2007;24(4):270\u20135.","journal-title":"Emerg Med J"},{"issue":"2","key":"4793_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.annemergmed.2019.08.429","volume":"75","author":"MA Probst","year":"2020","unstructured":"Probst MA, Gibson T, Weiss RE, et al. Risk stratification of older adults who present to the emergency department with Syncope: the FAINT score. Ann Emerg Med. 2020;75(2):147\u201358.","journal-title":"Ann Emerg Med"},{"key":"4793_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ijcard.2016.12.021","volume":"231","author":"AL Aro","year":"2017","unstructured":"Aro AL, Rusinaru C, Uy-Evanado A, et al. Syncope and risk of sudden cardiac arrest in coronary artery disease. Int J Cardiol. 2017;231:26\u201330.","journal-title":"Int J Cardiol"},{"key":"4793_CR17","doi-asserted-by":"publisher","first-page":"102637","DOI":"10.1016\/j.nano.2022.102637","volume":"48","author":"SH Nemati","year":"2023","unstructured":"Nemati SH, et al. Neuroprotective effects of niosomes loaded with thymoquinone in the cerebral ischemia model of male Wistar rats. Nanomedicine: Nanotechnol Biol Med. 2023;48:102637.","journal-title":"Nanomedicine: Nanotechnol Biol Med"},{"key":"4793_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s12668-024-01755-9","volume":"15","author":"Z Sadeghian","year":"2025","unstructured":"Sadeghian Z, Bigdeli MR, Mortazavi Moghadam F, et al. Niosome: A Stable Antioxidant Drug Delivery System and Improvement Effect on Neurological Defects in Animal Model of Stroke. BioNanoSci. 2025;15:117. https:\/\/doi.org\/10.1007\/s12668-024-01755-9.","journal-title":"BioNanoSci."},{"key":"4793_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bios.2019.02.046","volume":"132","author":"FM Moghadam","year":"2019","unstructured":"Moghadam FM, Rahaie M. A signal-on nanobiosensor for VEGF165 detection based on supraparticle copper nanoclusters formed on bivalent aptamer. Biosens Bioelectron. 2019;132:186\u201395.","journal-title":"Biosens Bioelectron"},{"key":"4793_CR20","doi-asserted-by":"crossref","unstructured":"A. J, M.R. B, F. M M. pH-sensitive oleuropein-loaded niosome: efficient treatment for metastatic brain tumors in initial steps in-vivo. OpenNano. 2022;8:100095.","DOI":"10.1016\/j.onano.2022.100095"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-04793-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-04793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T11:16:37Z","timestamp":1746443797000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-04793-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4793"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-04793-7","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]},"assertion":[{"value":"22 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study received ethical approval under the ethics approval number 2024-k-59, granted by the Clinical Research Ethics Committee of Handan First Hospital. The project was reviewed and approved via the committee's fast-track process. Informed consent was obtained from all individual participants included in the study prior to their participation.\nThis study was conducted in accordance with the principles outlined in the Declaration of Helsinki and its subsequent amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"348"}}