{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:06:55Z","timestamp":1758931615521,"version":"3.44.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-05134-4","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:49:00Z","timestamp":1758880140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does cryoballoon ablation affect the symptom severity of atrial fibrillation? Insights from 12-months continuous cardiac monitoring"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-3997","authenticated-orcid":false,"given":"Karapet","family":"Davtyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-6316","authenticated-orcid":false,"given":"Arpi","family":"Topchyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-3592","authenticated-orcid":false,"given":"Hakob","family":"Brutyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-0353","authenticated-orcid":false,"given":"Elena","family":"Kalemberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-5376","authenticated-orcid":false,"given":"Georgiy","family":"Simonyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-6963","authenticated-orcid":false,"given":"Svetlana","family":"Serdyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-4857","authenticated-orcid":false,"given":"Maria","family":"Kharlap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-5459","authenticated-orcid":false,"given":"Ekaterina","family":"Bazaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"issue":"5","key":"5134_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"G Hindricks","year":"2020","unstructured":"Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstr\u00f6m-Lundqvist C, et al. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European association for Cardio-Thoracic surgery (EACTS). Eur Heart J. 2020;42(5):373\u2013498.","journal-title":"Eur Heart J"},{"issue":"1","key":"5134_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.15420\/aer.2019.13","volume":"9","author":"JG Andrade","year":"2020","unstructured":"Andrade JG, Deyell MW, Verma A, MacLe L, Khairy P. The cryoballoon vs irrigated radiofrequency catheter ablation (CIRCA-DOSE) study results in context. Arrhythm Electrophysiol Rev. 2020;9(1):34.","journal-title":"Arrhythm Electrophysiol Rev"},{"issue":"3","key":"5134_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1161\/CIRCULATIONAHA.104.518837","volume":"112","author":"G Hindricks","year":"2005","unstructured":"Hindricks G, Piorkowski C, Tanner H, Kobza R, Gerds-Li JH, Carbucicchio C, et al. Perception of atrial fibrillation before and after radiofrequency catheter ablation: relevance of asymptomatic arrhythmia recurrence. Circulation. 2005;112(3):307\u201313.","journal-title":"Circulation"},{"issue":"2","key":"5134_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1001\/jamainternmed.2013.1561","volume":"173","author":"A Verma","year":"2013","unstructured":"Verma A, Champagne J, Sapp J, Essebag V, Novak P, Skanes A, et al. Discerning the incidence of symptomatic and asymptomatic episodes of atrial fibrillation before and after catheter ablation (DISCERN AF): A prospective, multicenter study. JAMA Intern Med. 2013;173(2):149\u201356.","journal-title":"JAMA Intern Med"},{"key":"5134_CR5","doi-asserted-by":"publisher","unstructured":"Davtyan K, Shatakhtsyan V, Poghosyan H, Deev A, Tarasov A, Kharlap M, et al. Radiofrequency versus cryoballoon ablation of atrial fibrillation: an evaluation using ECG, Holter monitoring, and implantable loop recorders to monitor absolute and clinical effectiveness. Biomed Res Int. 2018;3629384. https:\/\/doi.org\/10.1155\/2018\/3629384.","DOI":"10.1155\/2018\/3629384"},{"issue":"1","key":"5134_CR6","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/s12872-021-02300-2","volume":"21","author":"KV Davtyan","year":"2021","unstructured":"Davtyan KV, Topchyan AH, Brutyan HA, Kalemberg EN, Kharlap MS, Simonyan GY, et al. The predictive role of early recurrences of atrial arrhythmias after pulmonary vein cryoballoon ablation. Is blanking period an outdated concept? Insights from 12-month continuous cardiac monitoring. BMC Cardiovasc Disord. 2021;21(1):483.","journal-title":"BMC Cardiovasc Disord."},{"issue":"2","key":"5134_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1161\/CIRCEP.109.877852","volume":"3","author":"G Hindricks","year":"2010","unstructured":"Hindricks G, Pokushalov E, Urban L, Taborsky M, Kuck KH, Lebedev D, et al. Performance of a new leadless implantable cardiac monitor in detecting and quantifying atrial fibrillation results of the XPECT trial. Circ Arrhythm Electrophysiol. 2010;3(2):141\u20137.","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"3","key":"5134_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/01.CIR.0000112641.16340.C7","volume":"109","author":"C Pappone","year":"2004","unstructured":"Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, et al. Pulmonary vein denervation enhances Long-Term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation. 2004;109(3):327\u201334.","journal-title":"Circulation"},{"issue":"9","key":"5134_CR9","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/jce.13262","volume":"28","author":"S Miyazaki","year":"2017","unstructured":"Miyazaki S, Nakamura H, Taniguchi H, Hachiya H, Kajiyama T, Watanabe T, et al. Autonomic nervous system modulation and clinical outcome after pulmonary vein isolation using the second-generation cryoballoon. J Cardiovasc Electrophysiol. 2017;28(9):1015\u201320.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"1","key":"5134_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10840-017-0295-x","volume":"51","author":"S Yanagisawa","year":"2018","unstructured":"Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, et al. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings. J Interventional Cardiac Electrophysiol. 2018;51(1):35\u201344.","journal-title":"J Interventional Cardiac Electrophysiol"},{"issue":"1","key":"5134_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10840-010-9491-7","volume":"29","author":"H Oswald","year":"2010","unstructured":"Oswald H, Klein G, Koenig T, Luesebrink U, Duncker D, Gardiwal A. Cryoballoon pulmonary vein isolation temporarily modulates the intrinsic cardiac autonomic nervous system. J Interventional Cardiac Electrophysiol. 2010;29(1):57\u201362.","journal-title":"J Interventional Cardiac Electrophysiol"},{"issue":"2","key":"5134_CR12","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10840-023-01581-1","volume":"68","author":"N Suzuki","year":"2023","unstructured":"Suzuki N, Inden Y, Yanagisawa S, Shimizu Y, Narita S, Hiramatsu K, et al. Different time course effect of autonomic nervous modulation after cryoballoon and Hotballoon catheter ablations for paroxysmal atrial fibrillation. J Intervent Cardiac Electrophysiol. 2023;68(2):355.","journal-title":"J Intervent Cardiac Electrophysiol."},{"issue":"7","key":"5134_CR13","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jacep.2022.04.017","volume":"8","author":"P Stojadinovi\u0107","year":"2022","unstructured":"Stojadinovi\u0107 P, Wichterle D, Peichl P, Nakagawa H, \u010cih\u00e1k R, Ha\u0161kov\u00e1 J, et al. Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation. JACC Clin Electrophysiol. 2022;8(7):895\u2013904.","journal-title":"JACC Clin Electrophysiol"},{"issue":"10","key":"5134_CR14","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1016\/j.hrthm.2015.05.034","volume":"12","author":"B Avitall","year":"2015","unstructured":"Avitall B, Kalinski A. Cryotherapy of cardiac arrhythmia: from basic science to the bedside. Heart Rhythm. 2015;12(10):2195\u2013203.","journal-title":"Heart Rhythm"},{"issue":"2","key":"5134_CR15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.hrthm.2014.11.012","volume":"12","author":"DN Kenigsberg","year":"2015","unstructured":"Kenigsberg DN, Martin N, Lim HW, Kowalski M, Ellenbogen KA. Quantification of the cryoablation zone demarcated by pre- and postprocedural electroanatomic mapping in patients with atrial fibrillation using the 28-mm second-generation cryoballoon. Heart Rhythm. 2015;12(2):283\u201390.","journal-title":"Heart Rhythm"},{"issue":"22","key":"5134_CR16","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1161\/CIRCULATIONAHA.119.042622","volume":"140","author":"JG Andrade","year":"2019","unstructured":"Andrade JG, Champagne J, Dubuc M, Deyell MW, Verma A, Macle L, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation assessed by continuous monitoring. Circulation. 2019;140(22):1779\u201388.","journal-title":"Circulation"},{"issue":"4","key":"5134_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1056\/NEJMoa2029980","volume":"384","author":"JG Andrade","year":"2021","unstructured":"Andrade JG, Wells GA, Deyell MW, Bennett M, Essebag V, Champagne J, et al. Cryoablation or drug therapy for initial treatment of atrial fibrillation. N Engl J Med. 2021;384(4):305\u201315.","journal-title":"N Engl J Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05134-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-05134-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05134-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:49:01Z","timestamp":1758880141000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-05134-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5134"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-05134-4","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"13 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We developed the study protocol following the Declaration of Helsinki, and the center\u2019s Independent Ethics Committee approved it. All patients signed the written informed consent before enrollment. We confirm that we have read the Journal\u2019s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"KD is a proctor for Medtronic. AT has received a speaker honorarium from Medtronic. The remaining authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"674"}}