{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:44:41Z","timestamp":1782186281828,"version":"3.54.5"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["313481\/2020-2"],"award-info":[{"award-number":["313481\/2020-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-05144-2","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:50:35Z","timestamp":1759312235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and factors associated with cardiometabolic multimorbidity: a cross-sectional study in older adults of the first Brazilian hypertension registry"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-522X","authenticated-orcid":false,"given":"Sandro Rog\u00e9rio Rodrigues","family":"Batista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4139-5467","authenticated-orcid":false,"given":"Leandro Ferreira","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-4649","authenticated-orcid":false,"given":"Priscila Valverde Vitorino","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-396X","authenticated-orcid":false,"given":"Andr\u00e9a Ara\u00fajo","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-936X","authenticated-orcid":false,"given":"Eduardo Costa Duarte","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-4720","authenticated-orcid":false,"given":"Audes Di\u00f3genes M","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-3920","authenticated-orcid":false,"given":"Marcus Vin\u00edcius Bolivar","family":"Malachias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-1533","authenticated-orcid":false,"given":"Marco Mota","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-760X","authenticated-orcid":false,"given":"Celso","family":"Amodeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-9151","authenticated-orcid":false,"given":"Rui Manoel dos Santos","family":"P\u00f3voa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4961","authenticated-orcid":false,"given":"Renato Delascio","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-013X","authenticated-orcid":false,"given":"Paulo C\u00e9sar Brand\u00e3o Veiga","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-3541","authenticated-orcid":false,"given":"Ana Luiza Lima","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-1930","authenticated-orcid":false,"given":"Weimar Kunz Sebba","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The first Brazilian Hypertension Registry (BHR) investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"issue":"1","key":"5144_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mayocpiqo.2023.08.005","volume":"8","author":"K Hacker","year":"2024","unstructured":"Hacker K. The burden of chronic disease. Mayo Clinic Proceedings: Innovations, Quality & Outcomes. 2024;8(1):112\u20139. https:\/\/doi.org\/10.1016\/j.mayocpiqo.2023.08.005.","journal-title":"Mayo Clinic Proceedings: Innovations, Quality & Outcomes"},{"key":"5144_CR2","unstructured":"WHO. Global Status Report on Noncommunicable Diseases 2014.Geneva: World Health Organization. 2014. Available at: https:\/\/apps.who.int\/iris\/handle\/10665\/148114"},{"issue":"4","key":"5144_CR3","doi-asserted-by":"publisher","first-page":"e1004229","DOI":"10.1371\/journal.pmed.1004229","volume":"20","author":"The PLOS Medicine Editors","year":"2023","unstructured":"The PLOS Medicine Editors. Multimorbidity: addressing the next global pandemic. PLoS Med. 2023;20(4):e1004229. https:\/\/doi.org\/10.1371\/journal.pmed.1004229.","journal-title":"PLoS Med"},{"issue":"12","key":"5144_CR4","doi-asserted-by":"publisher","first-page":"e599","DOI":"10.1016\/S2468-2667(19)30222-1","volume":"4","author":"J Pearson-Stuttard","year":"2019","unstructured":"Pearson-Stuttard J, Ezzati M, Gregg EW. Multimorbidity\u2014a defining challenge for health systems. Lancet Public Health. 2019;4(12):e599\u2013600. https:\/\/doi.org\/10.1016\/S2468-2667(19)30222-1.","journal-title":"Lancet Public Health"},{"issue":"9699","key":"5144_CR5","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/S0140-6736(09)61863-8","volume":"374","author":"LG Glynn","year":"2009","unstructured":"Glynn LG. Multimorbidity: another key issue for cardiovascular medicine. Lancet. 2009;374(9699):1421\u20132. https:\/\/doi.org\/10.1016\/S0140-6736(09)61863-8.","journal-title":"Lancet"},{"issue":"7","key":"5144_CR6","doi-asserted-by":"publisher","first-page":"e0271639","DOI":"10.1371\/journal.pone.0271639","volume":"17","author":"SR Batista","year":"2022","unstructured":"Batista SR, Sousa ALL, Nunes BP, Silva RR, Jardim PCBV. Identifying multimorbidity clusters among Brazilian older adults using network analysis: findings and perspectives. PLoS One. 2022;17(7):e0271639. https:\/\/doi.org\/10.1371\/journal.pone.0271639.","journal-title":"PLoS One"},{"issue":"10033","key":"5144_CR7","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","volume":"387","author":"JR Beard","year":"2016","unstructured":"Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, Lloyd-Sherlock P, Epping-Jordan JE, Peeters GMEEG, Mahanani WR, Thiyagarajan JA, Chatterji S. The world report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145\u201354. https:\/\/doi.org\/10.1016\/S0140-6736(15)00516-4.","journal-title":"Lancet"},{"issue":"19","key":"5144_CR8","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.jacc.2018.03.022","volume":"71","author":"DE Forman","year":"2018","unstructured":"Forman DE, Maurer MS, Boyd C, Brindis R, Salive ME, Horne FM, Bell SP, Fulmer T, Reuben DB, Zieman S, Rich MW. Multimorbidity in older adults with cardiovascular disease. J Am Coll Cardiol. 2018;71(19):2149\u201361. https:\/\/doi.org\/10.1016\/j.jacc.2018.03.022.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"5144_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1001\/jama.2015.7008","volume":"314","author":"Emerging Risk Factors Collaboration","year":"2015","unstructured":"Emerging Risk Factors Collaboration. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015;314(1):52. https:\/\/doi.org\/10.1001\/jama.2015.7008.","journal-title":"JAMA"},{"key":"5144_CR10","doi-asserted-by":"publisher","DOI":"10.1177\/26335565211032880","volume":"11","author":"P Kudesia","year":"2021","unstructured":"Kudesia P, Salimarouny B, Stanley M, Fortin M, Stewart M, Terry A, Ryan BL. The incidence of multimorbidity and patterns in accumulation of chronic conditions: a systematic review. Journal of Multimorbidity and Comorbidity. 2021;11: 26335565211032880. https:\/\/doi.org\/10.1177\/26335565211032880.","journal-title":"Journal of Multimorbidity and Comorbidity"},{"issue":"2","key":"5144_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/gerona\/glv128","volume":"71","author":"N Garin","year":"2016","unstructured":"Garin N, Koyanagi A, Chatterji S, Tyrovolas S, Olaya B, Leonardi M, Lara E, Koskinen S, Tobiasz-Adamczyk B, Ayuso-Mateos JL, Haro JM. Global multimorbidity patterns: a cross-sectional, population-based, multi-country study. J Gerontol A Biol Sci Med Sci. 2016;71(2):205\u201314. https:\/\/doi.org\/10.1093\/gerona\/glv128.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"5144_CR12","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1186\/s12889-019-7682-4","volume":"19","author":"BM Sakakibara","year":"2019","unstructured":"Sakakibara BM, Obembe AO, Eng JJ. The prevalence of cardiometabolic multimorbidity and its association with physical activity, diet, and stress in Canada: evidence from a population-based cross-sectional study. BMC Public Health. 2019;19(1):1361. https:\/\/doi.org\/10.1186\/s12889-019-7682-4.","journal-title":"BMC Public Health"},{"issue":"1","key":"5144_CR13","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1186\/s12889-023-17008-5","volume":"23","author":"Z Jiang","year":"2023","unstructured":"Jiang Z, Zhang S, Zeng P, Wang T. Influence of social deprivation on morbidity and all-cause mortality of cardiometabolic multi-morbidity: a cohort analysis of the UK biobank cohort. BMC Public Health. 2023;23(1):2177. https:\/\/doi.org\/10.1186\/s12889-023-17008-5.","journal-title":"BMC Public Health"},{"issue":"7","key":"5144_CR14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/eurheartj\/ehac744","volume":"44","author":"A Dove","year":"2023","unstructured":"Dove A, Guo J, Marseglia A, Fastbom J, Vetrano DL, Fratiglioni L, Pedersen NL, Xu W. Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry. Eur Heart J. 2023;44(7):573\u201382. https:\/\/doi.org\/10.1093\/eurheartj\/ehac744.","journal-title":"Eur Heart J"},{"issue":"3","key":"5144_CR15","doi-asserted-by":"publisher","first-page":"e024476","DOI":"10.1136\/bmjopen-2018-024476","volume":"9","author":"D Zhang","year":"2019","unstructured":"Zhang D, Tang X, Shen P, Si Y, Liu X, Xu Z, Wu J, Zhang J, Lu P, Lin H, Gao P. Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study. BMJ Open. 2019;9(3):e024476. https:\/\/doi.org\/10.1136\/bmjopen-2018-024476.","journal-title":"BMJ Open"},{"key":"5144_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhip.2021.100193","volume":"2","author":"R Sewpaul","year":"2021","unstructured":"Sewpaul R, Mbewu AD, Fagbamigbe AF, Kandala NB, Reddy SP. Prevalence of multimorbidity of cardiometabolic conditions and associated risk factors in a population-based sample of South Africans: a cross-sectional study. Public Health Pract. 2021;2: 100193. https:\/\/doi.org\/10.1016\/j.puhip.2021.100193.","journal-title":"Public Health Pract"},{"key":"5144_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1380715","volume":"11","author":"M Agudelo-Botero","year":"2024","unstructured":"Agudelo-Botero M, D\u00e1vila-Cervantes CA, Giraldo-Rodr\u00edguez L. Cardiometabolic multimorbidity in Mexican adults: a cross-sectional analysis of a national survey. Front Med. 2024;11: 1380715. https:\/\/doi.org\/10.3389\/fmed.2024.1380715.","journal-title":"Front Med"},{"issue":"8","key":"5144_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19084726","volume":"19","author":"X Cheng","year":"2022","unstructured":"Cheng X, Ma T, Ouyang F, Zhang G, Bai Y. Trends in the prevalence of cardiometabolic multimorbidity in the United States, 1999\u20132018. Int J Environ Res Public Health. 2022;19(8): 4726. https:\/\/doi.org\/10.3390\/ijerph19084726.","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"5144_CR19","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1161\/CIRCRESAHA.121.319811","volume":"130","author":"TM Powell-Wiley","year":"2022","unstructured":"Powell-Wiley TM, Baumer Y, Baah FO, Baez AS, Farmer N, Mahlobo CT, Pita MA, Potharaju KA, Tamura K, Wallen GR. Social determinants of cardiovascular disease. Circ Res. 2022;130(5):782\u201399. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.319811.","journal-title":"Circ Res"},{"issue":"10","key":"5144_CR20","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.numecd.2022.06.016","volume":"32","author":"D Li","year":"2022","unstructured":"Li D, Wang L, Zhou Z, Song L, Chen S, Yang Y, Hu Y, Wang Y, Wu S, Tian Y. Role of socioeconomic, lifestyle, and clinical factors in the progression of cardiometabolic multimorbidity in China: a 10-year prospective cohort study. Nutr Metab Cardiovasc Dis. 2022;32(10):2383\u201391. https:\/\/doi.org\/10.1016\/j.numecd.2022.06.016.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"3","key":"5144_CR21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s44161-024-00438-8","volume":"3","author":"M Jiang","year":"2024","unstructured":"Jiang M, Tian S, Liu S, Wang Y, Guo X, Huang T, Lin X, Belsky DW, Baccarelli AA, Gao X. Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality. Nat Cardiovasc Res. 2024;3(3):332\u201342. https:\/\/doi.org\/10.1038\/s44161-024-00438-8.","journal-title":"Nat Cardiovasc Res"},{"issue":"2","key":"5144_CR22","doi-asserted-by":"publisher","first-page":"e064275","DOI":"10.1136\/bmjopen-2022-064275","volume":"13","author":"P Otieno","year":"2023","unstructured":"Otieno P, Asiki G, Wekesah F, Wilunda C, Sanya RE, Wami W, Agyemang C. Multimorbidity of cardiometabolic diseases: a cross-sectional study of patterns, clusters and associated risk factors in sub-Saharan Africa. BMJ Open. 2023;13(2):e064275. https:\/\/doi.org\/10.1136\/bmjopen-2022-064275.","journal-title":"BMJ Open"},{"issue":"Supplement1","key":"5144_CR23","doi-asserted-by":"publisher","first-page":"ehae6662553","DOI":"10.1093\/eurheartj\/ehae666.2553","volume":"45","author":"C Janssen-Telders","year":"2024","unstructured":"Janssen-Telders C, Schlaich M, Schutte AE, Stergiou G, Poulter NR, Beaney T. Risk factors for cardiometabolic multimorbidity: an analysis of 4 million participants from May measurement month 2017\u20132019. Eur Heart J. 2024;45(Supplement1):ehae6662553. https:\/\/doi.org\/10.1093\/eurheartj\/ehae666.2553.","journal-title":"Eur Heart J"},{"issue":"10","key":"5144_CR24","doi-asserted-by":"publisher","first-page":"e2238361","DOI":"10.1001\/jamanetworkopen.2022.38361","volume":"5","author":"JJ Joseph","year":"2022","unstructured":"Joseph JJ, Rajwani A, Roper D, Zhao S, Kline D, Odei J, Brock G, Echouffo-Tcheugui JB, Kalyani RR, Bertoni AG, Effoe VS, Sims M, Wu WC, Wand GS, Golden SH. Associations of cardiometabolic multimorbidity with all-cause and coronary heart disease mortality among black adults in the Jackson heart study. JAMA Netw Open. 2022;5(10):e2238361. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.38361.","journal-title":"JAMA Netw Open"},{"issue":"1","key":"5144_CR25","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12916-021-02126-x","volume":"19","author":"D Canoy","year":"2021","unstructured":"Canoy D, Tran J, Zottoli M, Ramakrishnan R, Hassaine A, Rao S, Li Y, Salimi-Khorshidi G, Norton R, Rahimi K. Association between cardiometabolic disease multimorbidity and all-cause mortality in 2 million women and men registered in UK general practices. BMC Med. 2021;19(1):258. https:\/\/doi.org\/10.1186\/s12916-021-02126-x.","journal-title":"BMC Med"},{"issue":"1","key":"5144_CR26","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1038\/s41598-025-87516-4","volume":"15","author":"D Guo","year":"2025","unstructured":"Guo D, Wang Y, Zhao Y, Ding R, Luo Y, Dai W, He P. The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China. Sci Rep. 2025;15(1):2971. https:\/\/doi.org\/10.1038\/s41598-025-87516-4.","journal-title":"Sci Rep"},{"issue":"1","key":"5144_CR27","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2024.1775","volume":"67","author":"W Yang","year":"2024","unstructured":"Yang W, Li W, Wang S, Qi X, Sun Z, Dove A, Xu W. Association of cardiometabolic multimorbidity with risk of late-life depression: a nationwide twin study. Eur Psychiatry. 2024;67(1): e58. https:\/\/doi.org\/10.1192\/j.eurpsy.2024.1775.","journal-title":"Eur Psychiatry"},{"key":"5144_CR28","doi-asserted-by":"publisher","first-page":"101198","DOI":"10.1016\/j.lanwpc.2024.101198","volume":"51","author":"X Zhao","year":"2024","unstructured":"Zhao X, Xu X, Yan Y, Lipnicki DM, Pang T, Crawford JD, Chen C, Cheng CY, Venketasubramanian N, Chong E, Blay SL, Lima-Costa MF, Castro-Costa E, Lipton RB, Katz MJ, Ritchie K, Scarmeas N, Yannakoulia M, Kosmidis MH, Gureje O, Ojagbemi A, Bello T, Hendrie HC, Gao S, Guerra RO, Auais M, Gomez JF, Rolandi E, Davin A, Rossi M, Riedel-Heller SG, L\u00f6bner M, Roehr S, Ganguli M, Jacobsen EP, Chang CH, Aiello AE, Ho R, Sanchez-Juan P, Valent\u00ed-Soler M, Ser TD, Lobo A, De-la-C\u00e1mara C, Lobo E, Sachdev PS, Xu X, for Cohort Studies of Memory in an International Consortium (COSMIC). Independent and joint associations of cardiometabolic Multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic. Lancet Reg Health - West Pac. 2024;51:101198. https:\/\/doi.org\/10.1016\/j.lanwpc.2024.101198.","journal-title":"Lancet Reg Health - West Pac"},{"issue":"6","key":"5144_CR29","doi-asserted-by":"publisher","first-page":"e265","DOI":"10.1016\/S2666-7568(23)00054-5","volume":"4","author":"Y Jin","year":"2023","unstructured":"Jin Y, Liang J, Hong C, Liang R, Luo Y. Cardiometabolic multimorbidity, lifestyle behaviours, and cognitive function: a multicohort study. Lancet Healthy Longev. 2023;4(6):e265\u201373. https:\/\/doi.org\/10.1016\/S2666-7568(23)00054-5.","journal-title":"Lancet Healthy Longev"},{"issue":"6","key":"5144_CR30","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S2666-7568(22)00117-9","volume":"3","author":"XY Tai","year":"2022","unstructured":"Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, Ranson J, Llewellyn DJ. Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet Healthy Longev. 2022;3(6):e428\u201336. https:\/\/doi.org\/10.1016\/S2666-7568(22)00117-9.","journal-title":"Lancet Healthy Longev"},{"issue":"3","key":"5144_CR31","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/alz.12708","volume":"19","author":"A Dove","year":"2023","unstructured":"Dove A, Marseglia A, Shang Y, Grande G, Vetrano DL, Laukka EJ, Fratiglioni L, Xu W. Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression. Alzheimers Dement. 2023;19(3):821\u201330. https:\/\/doi.org\/10.1002\/alz.12708.","journal-title":"Alzheimers Dement"},{"key":"5144_CR32","doi-asserted-by":"publisher","unstructured":"Jardim PCBV, Barroso WKS, Lopes RD, Brand\u00e3o AA, Malachias MV, Gomes MM, Moreno J\u00fanior H, Barbosa EC, P\u00f3voa RM. I RBH - First Brazilian Hypertension Registry. Arq Bras Cardiol. Published online 2016. https:\/\/doi.org\/10.5935\/abc.20160120","DOI":"10.5935\/abc.20160120"},{"key":"5144_CR33","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ahj.2018.08.012","volume":"205","author":"RD Lopes","year":"2018","unstructured":"Lopes RD, Barroso WKS, Brandao AA, Barbosa ECD, Malachias MVB, Gomes MM, Amodeo C, Dos Santos Povoa RM, Cavalcante MA, Pr\u00e9coma DB, Sousa ACS, Dantas JMM, Cesarino EJ, Veiga Jardim PCB, RBH investigators. The first Brazilian registry of hypertension. Am Heart J. 2018;205:154\u20137. https:\/\/doi.org\/10.1016\/j.ahj.2018.08.012.","journal-title":"Am Heart J"},{"issue":"1 Suppl","key":"5144_CR34","first-page":"1","volume":"95","author":"Sociedade Brasileira de Cardiologia","year":"2010","unstructured":"Sociedade Brasileira de Cardiologia. Sociedade Brasileira de hipertens\u00e3o, sociedade Brasileira de nefrologia. [VI Brazilian guidelines on hypertension]. Arq Bras Cardiol. 2010;95(1 Suppl):1\u201351.","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"5144_CR35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12916-022-02389-y","volume":"20","author":"Y Lu","year":"2022","unstructured":"Lu Y, Li G, Ferrari P, Freisling H, Qiao Y, Wu L, Shao L, Ke C. Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity. BMC Med. 2022;20(1):191. https:\/\/doi.org\/10.1186\/s12916-022-02389-y.","journal-title":"BMC Med"},{"issue":"10","key":"5144_CR36","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1093\/gerona\/glz185","volume":"75","author":"SS Yao","year":"2020","unstructured":"Yao SS, Cao GY, Han L, Chen ZS, Huang ZT, Gong P, Hu Y, Xu B. Prevalence and patterns of multimorbidity in a nationally representative sample of older Chinese: results from the China health and retirement longitudinal study. J Gerontol Ser A. 2020;75(10):1974\u201380. https:\/\/doi.org\/10.1093\/gerona\/glz185.","journal-title":"J Gerontol Ser A"},{"key":"5144_CR37","doi-asserted-by":"publisher","DOI":"10.1177\/2235042X20961919","volume":"10","author":"F Abebe","year":"2020","unstructured":"Abebe F, Schneider M, Asrat B, Ambaw F. Multimorbidity of chronic non-communicable diseases in low- and middle-income countries: a scoping review. J Comorbidity. 2020;10: 2235042X2096191. https:\/\/doi.org\/10.1177\/2235042X20961919.","journal-title":"J Comorbidity"},{"key":"5144_CR38","doi-asserted-by":"publisher","first-page":"ehw528","DOI":"10.1093\/eurheartj\/ehw528","volume":"15","author":"DM Lyall","year":"2016","unstructured":"Lyall DM, Celis-Morales CA, Anderson J, Gill JM, Mackay DF, McIntosh AM, Smith DJ, Deary IJ, Sattar N, Pell JP. Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK biobank participants. Eur Heart J Published Online November. 2016;15:ehw528. https:\/\/doi.org\/10.1093\/eurheartj\/ehw528.","journal-title":"Eur Heart J Published Online November"},{"issue":"3","key":"5144_CR39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.36660\/abc.20220063","volume":"118","author":"WKS Barroso","year":"2022","unstructured":"Barroso WKS, Batista SR, Vitorino PVDO, Sousa ALL. Influence of Racial composition on blood pressure control in the Brazilian population: the need for new perspectives beyond drug treatment. Arq Bras Cardiol. 2022;118(3):623\u20134. https:\/\/doi.org\/10.36660\/abc.20220063.","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"5144_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-024-03811-3","volume":"23","author":"L Steell","year":"2025","unstructured":"Steell L, Krauth SJ, Ahmed S, Dibben GO, McIntosh E, Hanlon P, Lewsey J, Nicholl BI, McAllister DA, Smith SM, Evans R, Ahmed Z, Dean S, Greaves C, Barber S, Doherty P, Gardiner N, Ibbotson T, Jolly K, Ormandy P, Simpson SA, Taylor RS, Singh SJ, Mair FS, Jani BD. PERFORM research team. Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts. BMC Med. 2025;23(1):1. https:\/\/doi.org\/10.1186\/s12916-024-03811-3.","journal-title":"BMC Med"},{"issue":"1","key":"5144_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-8112-3","volume":"20","author":"G Sum","year":"2020","unstructured":"Sum G, Koh GC, Mercer SW, Wei LY, Majeed A, Oldenburg B, Lee JT. Patients with more comorbidities have better detection of chronic conditions, but poorer management and control: findings from six middle-income countries. BMC Public Health. 2020;20(1): 9. https:\/\/doi.org\/10.1186\/s12889-019-8112-3.","journal-title":"BMC Public Health"},{"key":"5144_CR42","doi-asserted-by":"publisher","first-page":"215013192312150","DOI":"10.1177\/21501319231215025","volume":"14","author":"TN Nguyen","year":"2023","unstructured":"Nguyen TN, Kalia S, Hanlon P, Jani BD, Nicholl BI, Christie CD, Aliarzadeh B, Moineddin R, Harrison C, Chow C, Fortin M, Mair FS, Greiver M. Multimorbidity and blood pressure control in patients attending primary care in Canada. J Prim Care Community Health. 2023;14:21501319231215025. https:\/\/doi.org\/10.1177\/21501319231215025.","journal-title":"J Prim Care Community Health"},{"issue":"7","key":"5144_CR43","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/jch.14501","volume":"24","author":"TDP Ara\u00fajo","year":"2022","unstructured":"Ara\u00fajo TDP, Borges LGS, Barroso WKS, Brand\u00e3o AA, Barbosa ECD, Feitosa ADM, Malachias MVB, Mota Gomes M, Amodeo C, Povoa RMDS, Jardim PCBV, Lopes RD, Batista SRR, Vitorino PVO. Researchers of study I rbh.factors associated with uncontrolled blood pressure in hypertensive Brazilians. J Clin Hypertens. 2022;24(7):814\u201324. https:\/\/doi.org\/10.1111\/jch.14501.","journal-title":"J Clin Hypertens"},{"issue":"6","key":"5144_CR44","doi-asserted-by":"publisher","first-page":"e1003674","DOI":"10.1371\/journal.pmed.1003674","volume":"18","author":"J Tran","year":"2021","unstructured":"Tran J, Norton R, Canoy D, Ayala Solares JR, Conrad N, Nazarzadeh M, Raimondi F, Salimi-Khorshidi G, Rodgers A, Rahimi K. Multi-morbidity and blood pressure trajectories in hypertensive patients: a multiple landmark cohort study. PLoS Med. 2021;18(6):e1003674. https:\/\/doi.org\/10.1371\/journal.pmed.1003674.","journal-title":"PLoS Med"},{"issue":"17","key":"5144_CR45","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025936","volume":"11","author":"L Yang","year":"2022","unstructured":"Yang L, Luo Y, He L, Yin J, Li T, Liu S, Li D, Cheng X, Bai Y. Shift work and the risk of cardiometabolic multimorbidity among patients with hypertension: a prospective cohort study of UK biobank. J Am Heart Assoc. 2022;11(17): e025936. https:\/\/doi.org\/10.1161\/JAHA.122.025936.","journal-title":"J Am Heart Assoc"},{"key":"5144_CR46","doi-asserted-by":"publisher","first-page":"e285","DOI":"10.1097\/01.hjh.0000549166.20829.9b","volume":"36","author":"SR Batista","year":"2018","unstructured":"Batista SR, Stein AT, Vitorino PVDO, Flores TR, Sousa ALL, Nunes BP. A10768 effect of Multimorbidity on blood pressure control among Brazilian adults: data from the 2013 National health survey. J Hypertens. 2018;36:e285\u20136. https:\/\/doi.org\/10.1097\/01.hjh.0000549166.20829.9b.","journal-title":"J Hypertens"},{"issue":"9","key":"5144_CR47","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/CIRCULATIONAHA.119.040151","volume":"140","author":"C W\u00f3jcik","year":"2019","unstructured":"W\u00f3jcik C, Shapiro MD. Bridging the gap between cardiology and family medicine: missed opportunities in cardiovascular disease prevention. Circulation. 2019;140(9):709\u201311. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.040151.","journal-title":"Circulation"},{"issue":"2","key":"5144_CR48","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1370\/afm.2028","volume":"15","author":"J Penm","year":"2017","unstructured":"Penm J, MacKinnon NJ, Strakowski SM, Ying J, Doty MM. Minding the gap: factors associated with primary care coordination of adults in 11 countries. Ann Fam Med. 2017;15(2):113\u20139. https:\/\/doi.org\/10.1370\/afm.2028.","journal-title":"Ann Fam Med"},{"issue":"7","key":"5144_CR49","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.recesp.2011.02.021","volume":"64","author":"C Falces","year":"2011","unstructured":"Falces C, Andrea R, Heras M, Veh\u00ed C, Sorribes M, Sanchis L, Cevallos J, Menacho I, Porcar S, Font D, Sabat\u00e9 M, Brugada J. Integration between cardiology and primary care: impact on clinical practice. Rev Esp Cardiol. 2011;64(7):564\u201371. https:\/\/doi.org\/10.1016\/j.recesp.2011.02.021.","journal-title":"Rev Esp Cardiol"},{"issue":"5","key":"5144_CR50","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1016\/S2666-7568(22)00074-5","volume":"3","author":"K Hwang","year":"2022","unstructured":"Hwang K, Moore KJ, Chong TWH, Williams S, Batchelor F. Improving clinical practice guidelines for older people: considerations and recommendations for more inclusive and ageing-relevant guidelines. Lancet Healthy Longev. 2022;3(5):e316\u20137. https:\/\/doi.org\/10.1016\/S2666-7568(22)00074-5.","journal-title":"Lancet Healthy Longev"},{"issue":"1","key":"5144_CR51","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ageing\/afs100","volume":"42","author":"LD Hughes","year":"2013","unstructured":"Hughes LD, McMurdo MET, Guthrie B. Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing. 2013;42(1):62\u20139. https:\/\/doi.org\/10.1093\/ageing\/afs100.","journal-title":"Age Ageing"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05144-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-05144-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05144-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:50:41Z","timestamp":1759312241000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-025-05144-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5144"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-05144-2","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"31 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The Research Ethics Committee of the Clinics Hospital of the Federal University of Goi\u00e1s approved the first BHR under protocol n\u00ba 532146. All participants signed an informed consent form before the interviews started. All participants were informed about the objectives of the research and signed separate informed consent forms for the interviews and physical measurements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The first BHR participants are volunteers who have provided written informed consent. No personal details were used in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"712"}}